Periodontitis and systemic disease

Winning, Lewis; Linden, Gerard

doi:10.1038/bdjteam.2015.163

Cited by 67 publications

(58 citation statements)

References 22 publications

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“…By studying how oPMN counts collected via an oral rinse vary as the oral milieu evolves, assays may be developed for the diagnosis of periodontal disease utilizing oPMN assessment which with potential benefits that extend beyond the realm of dentistry. Numerous studies have demonstrated the correlation between periodontal disease and systemic conditions including cardiovascular disease, diabetes, and rheumatoid arthritis and it is thought that inflammation, represented by oPMN counts, may be the link between periodontitis and these conditions 68 . Correlation between periodontitis and systemic diseases indicates a possible role for early identification of periodontitis in terms of monitoring systemic conditions, as evidenced by studies showing overall healthcare costs for diabetic patients being reduced by hundreds of dollars annually when periodontal preventive treatment is provided 69,70 .…”

Section: Implications Of Using Oral Neutrophil Counts In Dentistrymentioning

confidence: 99%

Oral inflammatory load: Neutrophils as oral health biomarkers

Khoury

Glogauer

Tenenbaum

et al. 2020

J of Periodontal Research

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Periodontal diseases present a significant challenge to our healthcare system in terms of morbidity from the disease itself as well as their putative and deleterious effects on systemic health. The current method of diagnosing periodontal disease utilizes clinical criteria solely. These are imprecise and are somewhat invasive. There is thus significant benefit to creating a non‐invasive test as a method of screening for and monitoring of periodontal diseases, and, in particular, chronic periodontitis. Oral polymorphonuclear neutrophil (oPMN) counts have been found to correlate with extent of oral inflammation and the presence and severity of periodontal diseases. Potentially then, quantification of oPMNs might be used to identify and measure the severity of oral inflammation (oral inflammatory load; OIL) in subjects with healthy and inflamed periodontal tissues, demonstrating a positive correlation between higher oPMN counts and the extent/severity of OIL. These findings support the development and utilization of a non‐invasive chair‐side test enabling rapid, accurate, and objective screening of OIL based on measurement of oPMN numbers (similar to white blood cell levels in blood as used in medicine for assessment of infection). The use of such a test before, during, and after treatment of gingivitis and periodontitis could lead to improvements in timing of intervention (ie, when inflammation is active) thereby reducing long‐term morbidity.

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Section: Implications Of Using Oral Neutrophil Counts In Dentistrymentioning

confidence: 99%

Oral inflammatory load: Neutrophils as oral health biomarkers

Khoury

Glogauer

Tenenbaum

et al. 2020

J of Periodontal Research

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“…It is characterized by the absorption of periodontal support tissues and degenerative lesions of the periodontal ligament, which in tandem cause loss of teeth . It was originally believed that the clinical hallmarks of periodontal disease were simply the local bacterial infection, but recent studies have shown that the detrimental clinical effects are secondary to excessive host inflammation in response to residing bacteria . Specifically, the Toll‐like receptors (TLRs) are critical to the pathogenesis of periodontal disease .…”

mentioning

confidence: 99%

“…7 It was originally believed that the clinical hallmarks of periodontal disease were simply the local bacterial infection, but recent studies have shown that the detrimental clinical effects are secondary to excessive host inflammation in response to residing bacteria. 8,9 Specifically, the Toll-like receptors (TLRs) are critical to the pathogenesis of periodontal disease. 10 The TLRs are pattern recognition receptors (PRRs) of innate immunity, they function both to activate the innate immune response and prime the adaptive response for successful host clearance of pathogens.…”

mentioning

confidence: 99%

Inhibition of angiotensin II receptor I prevents inflammation and bone loss in periodontitis

Xiao

Wei

et al. 2018

Journal of Periodontology

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“…Periodontal disease or tooth loss has been found to be associated with increased risk of systemic disease, including diabetes,8,9 cardiovascular disease,10,11 oral and GI cancers,12–14 and some other diseases and conditions 15,16. It is well established that bacterial infection resulting from dysbiosis of oral microbiota is the main cause of periodontal disease 17.…”

Section: Introductionmentioning

confidence: 99%

<p>Oral Microbiota as Promising Diagnostic Biomarkers for Gastrointestinal Cancer: A Systematic Review</p>

Chen¹,

Chen²,

Yu³

et al. 2019

OTT

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Emerging evidence has shown the potential of oral microbiota as a noninvasive diagnostic tool in gastrointestinal (GI) cancer. PubMed, Web of Science, and Embase were systematically searched for eligible studies published until May 31, 2019. Of the 17 included studies published between 2011 and 2019, five kinds of GI cancer, including colorectal cancer (n=6), pancreatic cancer (n=5), gastric cancer (n=4), esophageal cancer (n=2) and liver cancer (n=1), were reported. Generally, the diagnostic performance of the multi-bacteria model for GI cancer was strong with the best area under the receiver operator characteristic curve (AUC) exceeding 0.90, but only one study had a validation phase. Pathogens involved in periodontal disease, such as Porphyromonas gingivalis and Tannerella forsythia, were linked to various kinds of GI cancer. Besides, more oral bacteria significantly differed between cases with upper digestive cancer and healthy controls when compared to colorectal cancer (the most common form of lower digestive cancer), probably indicating a different mechanism due to anatomical and physiological differences in the digestive tract. Oral microbiota changes were associated with risk of various kinds of GI cancer, which could be considered as a potential tool for early prediction and prevention of GI cancer, but validation based on a large population, reproducible protocols for oral microbiota research and oral-gut microbiota transmission patterns are required to be resolved in further studies.

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Periodontitis and systemic disease

Cited by 67 publications

References 22 publications

Oral inflammatory load: Neutrophils as oral health biomarkers

Oral inflammatory load: Neutrophils as oral health biomarkers

Inhibition of angiotensin II receptor I prevents inflammation and bone loss in periodontitis

<p>Oral Microbiota as Promising Diagnostic Biomarkers for Gastrointestinal Cancer: A Systematic Review</p>

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