Perioperative administration of parenteral fish oil supplements in a routine clinical setting improves patient outcome after major abdominal surgery

Soybean and Fish Oil Mixture With Different ω‐6/ω‐3 Polyunsaturated Fatty Acid Ratios Modulates Dextran Sulfate Sodium–Induced Changes in Small Intestinal Intraepithelial γδT‐Lymphocyte Expression in Mice

“…This amount of ω‐3 PUFA and the fatty acid ratio mimic the previous study, which used Fat‐1 transgenic mice as the DSS‐treated model and found de novo synthesized ω‐3 PUFA had favorable effect in colitis 14 . Also, a previous study reported that perioperative administration of parenteral fish oil with ω‐6/ω‐3 PUFA ratios of 2–4:1 improves outcomes of surgical patients 23 . In this study, we administered the FO diet for 2 weeks before DSS treatment.…”

Pretreatment With an Intravenous Lipid Emulsion Increases Plasma Eicosapentanoic Acid and Downregulates Leukotriene B4, Procalcitonin, and Lymphocyte Concentrations After Open Heart Surgery in Infants

“…Fish oil intake has been reported to be associated with reduced synthesis of inflammatory eicosanoids and cytokines, a clinically significant anti‐inflammatory effect, and improved clinical outcomes 19 , 34 , 35 . This immunomodulation has been further shown to affect clinical outcomes, such as decreasing the need for mechanical ventilation and hospital length of stay 19 , 36 …”

Short‐term infusion of a fish oil‐based lipid emulsion modulates fatty acid status, but not immune function or (anti)oxidant balance: a randomized cross‐over study

“…In surgical patients, FO infusion has been shown to be safe [7], and possible improvements in immune function and reduced inflammatory response [11] have been observed and linked to clinical outcome measures [5][6][7]. In surgical patients, FO infusion has been shown to be safe [7], and possible improvements in immune function and reduced inflammatory response [11] have been observed and linked to clinical outcome measures [5][6][7].…”

“…Several studies have focused on clinical outcomes of parenteral FO in septic and gastrointestinal surgical patients, such as the length of hospital stay, mortality rates and the postoperative normalization of organ function [4][5][6][7][8]. Generally, the findings suggest a clinical benefit of parenteral FO, with several studies showing that FO infusion to postoperative and septic patients indeed modulates the generation of inflammatory cytokines and eicosanoids [9][10][11].…”