Perioperative Changes in Circulating Leptin Levels in Women Undergoing Total Abdominal Hysterectomy.

Abstract

Abstract.To investigate the effects of total abdominal hysterectomy on circulating leptin levels, 16 pre-and 8 postmenopausal patients with uterine leiomyoma or carcinoma in situ of the uterine cervix were enrolled. Serum levels of leptin and fasting blood sugar (FBS) were determined before (day -7) and after surgery (day +1 and +7). Body mass index (BMI) was recorded at day -7 and +7. Anesthesia duration, surgical duration, hematology, and blood loss during surgery were recorded. Relations of these variables to serum leptin levels were investigated. Serum leptin levels rose from 7.3 ±4.7 ng/mL to 9.3 ±5.8 ng/mL at day + 1 (P<0.01), then decreased to 4.9±3.0 ng/mL at day +7 (P< 0.05 vs. values at day -7 and +1). FBS levels also rose from 89.4± 7.5 mg/dL to 119.3±24.0mg /dL (P<0.01), then returned to normal at day +7 (96.2±9.0 mg/dL).However, there was no significant correlation observed between FBS and leptin levels at each time point (r<0.22).BMI decreased from 22.7±3.0 kg/m2 to 21.7 ±2.9 kg/m2 at day + 7 (P< 0.001). At day -7 and +7, leptin levels were positively correlatd with BMI (r= 0.79, P<0.001 and r=0.71, P<0.001, respectively).Circulating leptin levels were increased on day one after total abdominal hysterectomy.

Changes in pre- and postoperative serum leptin concentrations in dogs with gallbladder mucocele and cholelithiasis

“…One study showed that serum leptin concentrations were gradually decreased from 16 h after operation in patients who underwent surgery due to trauma or large bowel diseases [30]. Similar results were also observed in a study in women who underwent total abdominal hysterectomy [31]. In veterinary medicine, a study reported changes in leptin concentrations before and after treatment in dogs with naturally occurring pituitary-dependent hyperadrenocorticism.…”

Similar Effects of General and Spinal Anaesthesia onPerioperative Stress Response in Patients Undergoing Haemorrhoidectomy

“…In our study, leptin increased 24 hours after surgery as in this study and IL-6 also increased postoperatively, but neither they nor we found any correlation between leptin and IL-6. The increase of leptin 24 hours after surgery is similar to observations reported by previous studies [ 6 , 7 , 12 , 17 ].…”

“…Leptin (OB protein), is the adipocyte-derived product of antiobesity gene and its circulating concentrations indirectly reflect body fat stores. Serum cytokines may upregulate leptin levels [ 3 , 5 , 6 ]. Leptin is structurally similar to the granulocyte colony-stimulating factor (G-CSF) from IL-6 cytokine family [ 3 ].…”