Similar Effects of General and Spinal Anaesthesia onPerioperative Stress Response in Patients Undergoing Haemorrhoidectomy

Abstract

Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-α: TNF-α), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to general and spinal anaesthesia groups (n = 7). Blood samples were drawn before induction and 24 hours after surgery. Perioperative levels of IL-6, TNF-α, CRP, cortisol, and leptin were comparable among the groups. Twenty four hours after surgery, TNF-α and cortisol did not change; IL-6 and CRP increased significantly in all patients. Significant increase in leptin levels was found in patients undergoing spinal anaesthesia. Except for the increase in leptin levels, there was no significant difference related to the effects of general and spinal anaesthesia.

Ropivacaine, Interleukin-6 and Tumor Necrosis Factor Alpha Plasma Levels during Intermittent Epidural and Continuous Wound Infusion of Ropivacaine for Analgesia after Hysterectomy or Myomectomy: An Observational Study

“…Furthermore, the role of ropivacaine on the inflammatory response following surgical trauma is still unclear. The levels of certain pro-inflammatory cytokines, that is, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) have been previously investigated after anesthesia in surgical patients [11][12][13] .…”

A randomized study of maternal serum cytokine levels following cesarean section under general or neuraxial anesthesia

“…8 The perioperative changes of serum TNF-a and IL-6 and the effects of different anesthetic techniques have been investigated in surgical patients. [9][10][11][12][13] However, most studies comparing neuraxial and general anesthesia have failed to demonstrate a difference in cytokine levels. [9][10][11][12][13] The effect of anesthetic technique for cesarean section on maternal cytokine levels has been studied only minimally.…”

“…[9][10][11][12][13] However, most studies comparing neuraxial and general anesthesia have failed to demonstrate a difference in cytokine levels. [9][10][11][12][13] The effect of anesthetic technique for cesarean section on maternal cytokine levels has been studied only minimally. 14 The aim of the study was to investigate the effect of neuraxial versus general anesthesia on serum IL-6 and TNF-a levels in healthy parturients undergoing elective cesarean section.…”

Anaesthesia and Stress Response to Surgery

“…Other authors have found similar effects of general and spinal anaesthesia on stress response in patients undergoing surgery. Perioperative levels of TNF, IL-6, CRP are comparable in both types of anaesthesia (Buyukkocak et al, 2006).…”