Background. Patients undergoing surgical or diagnostic procedures, as well as critically ill patients, often suffer from psychoactive substance use disorders. The term “psychoactive substances” here includes both narcotics and psychotropic substances (or their analogs) as well as their precursors. They are strongly associated with drug addiction and such behavioral disorders as addictive behavior and delinquency. People with drug addiction is a high-risk group due to a variety of physical and mental factors. Common comorbidities in this population include human immunodeficiency virus, viral hepatitis, and infections caused by resistant strains of microorganisms. Clinical practice shows that medical professionals often underestimate the likelihood of disorders that occur in such patients before surgery. Generally, disorders related to the abuse of psychoactive substances are treatable, and most pathophysiological changes in organ functions are reversible. Early detection of such disorders and the risks associated with them is crucial for the timely use of the appropriate preventive measures in order to reduce the frequency and severity of these complications. Despite the increased perioperative risk, these patients can be treated safely if multidisciplinary treatment strategies are implemented. Psychoactive substance abuse leads to a wide spectrum of disorders, regardless of whether it is occasional cannabis usage or severe dependence on stimulants or narcotics. This explains the need for a personalized approach from an anesthesiologist to avoid complications associated with the use of cannabinoids, cocaine, amphetamines, or opioids. Therefore, the need for an individual approach to perioperative anesthesiological management with mandatory monitoring and personalized selection of anesthesia techniques and methods is justified. Conclusions. Drug addiction can be successfully managed if it is detected in time by an anesthesiologist during the preoperative period. Knowledge of the main pharmacological effects and clinical signs of prolonged psychoactive substance use in patients allows anesthesiologists to proactively outline the optimal strategy for anesthetic management of such patients during surgical interventions.