Perioperative myocardial cell damage assessed by immunoradiometric assay of β-myosin heavy chain serum levels in patients undergoing coronary bypass surgery

Astorri, E; Fiorina, Paolo; Gavaruzzi, Gilberto; Contini, Giovanni; Fesani, F

doi:10.1016/0167-5273(96)02673-3

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…Nonetheless, it is frequently found in the serum of patients with cardiac injury [50]. The appearance of this protein in the serum of our stressed rats could indicate cardiac involvement caused by the surgical trauma or, more probably, by blood loss during the experimental stress procedure.…”

Section: Serummentioning

confidence: 93%

Transcriptomic and proteomic analysis of liver and muscle alterations caused by surgical stress in rats

López-Hellı́n¹,

Gonzalo²,

Tejeda³

et al. 2005

Clinical Science

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The metabolic response to injury includes major alterations in protein metabolism; however, little is known about alterations in the synthesis of individual proteins and their role in the stress response. Our aim was to study how individual proteins in liver and muscle are altered by abdominal surgery. Changes produced in mRNA and proteins by abdominal surgery were studied in rats using RAP (random arbitrary priming)-PCR, to investigate mRNA alterations, and standard or isotopic (with in vivo radioactive labelling of proteins) two-dimensional electrophoresis/MS proteomic analyses, to study differential expression of proteins. Many of the differentially expressed proteins identified in blood were specifically synthesized by the liver to participate in the stress response. The hepatic proteins (antioxidant proteins, serine protease inhibitors, acute-phase proteins and transport proteins) were secreted into the bloodstream to produce a systemic action, indicating the central role of the liver in the stress response. Overexpressed proteins identified in liver were associated with the glycolytic processes and the folding of nascent proteins, confirming the high metabolic activity of the liver after surgery. The role of skeletal muscle protein as an amino acid donor to fuel the processes involved in the stress response was shown by the decrease in high-molecular-mass myofibrillar proteins. Combined use of the three techniques studied, differential RAP-PCR and standard and isotopic proteome analysis, provided complementary information on the differentially expressed proteins in a rat model of surgical stress.

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Section: Serummentioning

confidence: 93%

Transcriptomic and proteomic analysis of liver and muscle alterations caused by surgical stress in rats

López-Hellı́n¹,

Gonzalo²,

Tejeda³

et al. 2005

Clinical Science

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show abstract

“…Some of myosin superfamily members were expressed in a cell-type-specific manner [ 20 ] and were reported to be increased in the blood of patients with several diseases, including autoimmune diseases [ 21 ], myocardial cell damages [ 22 , 23 ], and skeletal muscle injuries [ 24 ]. Myosin heavy chain 11 (myosin-11) is exclusively enriched in VSMCs [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Increased Plasma Levels of Myosin Heavy Chain 11 Is Associated with Atherosclerosis

Takahashi

Ishigami

Tomiyama

et al. 2021

JCM

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Many studies have revealed numerous potential biomarkers for atherosclerosis, but tissue-specific biomarkers are still needed. Recent lineage-tracing studies revealed that smooth muscle cells (SMCs) contribute substantially to plaque formation, and the loss of SMCs causes plaque vulnerability. We investigated the association of SMC-specific myosin heavy chain 11 (myosin-11) with atherosclerosis. Forty-five patients with atherosclerosis and 34 control subjects were recruited into our study. In the atherosclerosis patients, 35 patients had either coronary artery disease (CAD) or peripheral artery disease (PAD), and 10 had both CAD and PAD. Coronary arteries isolated from five patients were subjected to histological study. Circulating myosin-11 levels were higher in the CAD or PAD group than in controls. The area under the receiver operating characteristic curve of myosin-11 was 0.954. Circulating myosin-11 levels in the CAD and PAD group were higher than in the CAD or PAD group, while high-sensitivity C-reactive protein concentrations did not differ between these groups. Multinomial logistic regression analyses showed a significant association of myosin-11 levels with the presence of multiple atherosclerotic regions. Myosin-11 was expressed in the medial layer of human atherosclerotic lesions where apoptosis elevated. Circulating myosin-11 levels may be useful for detecting spatial expansion of atherosclerotic regions.

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Durchblutungsstörungen des Myokard

Hort¹,

Arnold²,

Frenzel³

2000

Pathologie Des Endokard, Der Kranzarterien Und Des Myokard

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Perioperative myocardial cell damage assessed by immunoradiometric assay of β-myosin heavy chain serum levels in patients undergoing coronary bypass surgery

Cited by 4 publications

References 24 publications

Transcriptomic and proteomic analysis of liver and muscle alterations caused by surgical stress in rats

Transcriptomic and proteomic analysis of liver and muscle alterations caused by surgical stress in rats

Increased Plasma Levels of Myosin Heavy Chain 11 Is Associated with Atherosclerosis

Durchblutungsstörungen des Myokard

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