Perioperative treatment with human growth hormone down-regulates apoptosis and increases superoxide production in PMN from patients undergoing infrarenal abdominal aortic aneurysm repair

Decker, D.; Springer, W.; Tolba, René; Lauschke, H.; Hirner, A.; Ruecker, Alexander von

doi:10.1016/j.ghir.2005.02.006

Cited by 12 publications

(7 citation statements)

References 40 publications

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“…Infiltrating inflammatory cells may contribute to the development of abdominal aortic dissection. Macrophages release MMP-9 which degrades collagen [27] , while neutrophils produce superoxide, H 2 O 2 , and MMP-9, with diminished expression of catalase [2] , [4] , [28] . In rodent models of acute peritonitis, n-3 PUFAs and resolvin D1 inhibited the stimulated migration of neutrophils into the peritoneal cavity [12] , [29] – [31] .…”

Section: Discussionmentioning

confidence: 99%

“…Activated neutrophils are a source of reactive oxygen species, including superoxide [28] , where superoxide may contribute to aortic dissection and aneurysm progression. Elevated levels of superoxide in the aortic wall induce apoptosis of smooth muscle cells [32] , [33] , decreases elastin mRNA and protein expression [32] , and increases fragmentation of the elastic lamellae [33] .…”

Section: Discussionmentioning

confidence: 99%

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N-3 PUFAs Protect against Aortic Inflammation and Oxidative Stress in Angiotensin II-Infused Apolipoprotein E-/- Mice

et al. 2014

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Abdominal aortic aneurysm is associated with infiltration of inflammatory cells into the aortic wall. The inflammatory response is also evident in animal models, such as apolipoprotein E-deficient (ApoE-/-) mice that have been infused with angiotensin II, prior to development of aortic aneurysm. Since omega-3 polyunsaturated fatty acids (n-3 PUFAs) and their metabolites have anti-inflammatory and pro-resolving activity, we hypothesised that dietary supplementation with n-3 PUFAs would protect against inflammatory processes in this mouse model. Twenty C57 and 20 ApoE-/- 3-4 week old male mice were supplemented with a low (0.14%, n = 10/group) or high (0.70%, n = 10/group) n-3 PUFA diet for 8 weeks before 2-day infusion with 0.9% saline or angiotensin II (1000 ng/kg/min). Four ApoE-/- mice on the low n-3 PUFA diet and none of the ApoE-/- mice on the high n-3 PUFA diet showed morphological evidence of abdominal aortic dissection. The plasma concentration of the n-3 PUFA metabolite, resolvin D1 was higher in angiotensin II-infused ApoE-/- mice fed the high, compared to the low n-3 PUFA diet. The number of neutrophils and macrophages infiltrating the abdominal aorta was elevated in ApoE-/- mice on the low n-3 PUFA diet, and this was significantly attenuated in mice that were fed the high n-3 PUFA diet. Most neutrophils and macrophages were associated with dissected aortas. Immunoreactivity of the catalytic subunit of nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase, Nox2, and superoxide were elevated in ApoE-/- mice that were fed the low n-3 PUFA diet, and this was also significantly attenuated in mice that were fed the high n-3 PUFA diet. Together, the findings indicate that supplementation of ApoE-/- mice with a diet high in n-3 PUFA content protected the mice against pro-inflammatory and oxidative stress responses following short-term infusion with angiotensin II.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

N-3 PUFAs Protect against Aortic Inflammation and Oxidative Stress in Angiotensin II-Infused Apolipoprotein E-/- Mice

et al. 2014

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“…They also showed that treatment of the lymphoma cells with antisense deoxyoligonucleotides to GH increased apoptosis, suggesting that endogenous GH plays an important role in the survival of lymphocytes exposed to stressful stimuli. In vivo effects of perioperative GH treatment on susceptibility to apoptosis of neutrophils were examined in elderly patients undergoing elective abdominal aortic aneurysm repair [122]. GH treatment distinctly reduced apoptosis in neutrophils before and after surgery.…”

Section: Anti-apoptotic Effectmentioning

confidence: 99%

Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system

Hattori

2009

Growth Hormone & IGF Research

186

139

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“…72,73 Clinical data suggest that rHGH may be effective in closing cutaneous defects of the epithelium and accelerating wound healing. 71,72,74 Animal and cell culture studies have shown that GH activates epidermal and epithelial cell migration and assists wound healing. 75–77 …”

Section: Treatment Of Persistent Corneal Epithelial Defectsmentioning

confidence: 99%

Novel Therapy to Treat Corneal Epithelial Defects: A Hypothesis with Growth Hormone

et al. 2015

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Impaired corneal wound healing that occurs with ocular surface disease, trauma, systemic disease, or surgical intervention can lead to persistent corneal epithelial defects (PCED), which result in corneal scarring, ulceration, opacification, corneal neovascularization, and, ultimately, visual compromise and vision loss. The current standard of care can include lubricants, ointments, bandage lenses, amniotic membranes, autologous serum eye drops, and corneal transplants. Various inherent problems exist with application and administration of these treatments, which often may not result in a completely healed surface. A topically applicable compound capable of promoting corneal epithelial cell proliferation and/or migration would be ideal to accelerate healing. We hypothesize that human growth hormone (HGH) is such a compound. In a recent study, HGH was shown to activate signal transducer and activators of transcription-5 (STAT5) signaling and promote corneal wound healing by enhancing corneal epithelial migration in a co-culture system of corneal epithelial cells and fibroblasts. These effects require an intact communication between corneal epithelia and fibroblasts. Further, HGH promotes corneal wound healing in a rabbit debridement model, thus demonstrating the effectiveness of HGH in vivo as well. In conclusion, HGH may represent an exciting and effective topical therapeutic to promote corneal wound healing.

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Perioperative treatment with human growth hormone down-regulates apoptosis and increases superoxide production in PMN from patients undergoing infrarenal abdominal aortic aneurysm repair

Cited by 12 publications

References 40 publications

N-3 PUFAs Protect against Aortic Inflammation and Oxidative Stress in Angiotensin II-Infused Apolipoprotein E-/- Mice

N-3 PUFAs Protect against Aortic Inflammation and Oxidative Stress in Angiotensin II-Infused Apolipoprotein E-/- Mice

Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system

Novel Therapy to Treat Corneal Epithelial Defects: A Hypothesis with Growth Hormone

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