Periorbital pigmentation: An alarming sign of metabolic syndrome

Abstract

Periorbital pigmentation is a commonly encountered condition which presents clinically as bilateral round, oval or semicircular homogenous dark brown pigmented macules in the periocular region. It may influence quality of life of an individual with its strong psychological impact. We present a case of middle-aged female patient, who had periorbital pigmentation as a manifestation of acanthosis nigricans. On evaluation, she was found to have hypertension, hyperglycemia, and dyslipidemia and she fulfilled the criteria for metabolic syndrome. We believe, it is important to evaluate the patients who present as periorbital pigmentation with clinical features of acanthosis nigricans for underlying metabolic syndrome. K E Y W O R D S acanthosis nigricans, metabolic syndrome, periorbital pigmentation How to cite this article: Zawar V, Daga S, Pawar M, Kumavat S. Periorbital pigmentation: An alarming sign of metabolic syndrome.

Skin disease related to metabolic syndrome in women

“…This link appears to start early, and a systematic review demonstrated the relationship between AN and IR/T2DM in children with obesity (Abraham and Rozmus, 2012). Periorbital pigmentation in a female patient with AN was proposed as an alarming sign of MetS (Zawar et al, 2019).…”

Polymorphisms in P53 and VEGFA genes in different subtypes of periorbital hyperpigmentation

“…In the literature, contradictory findings have been published about the connection between gender and obesity. According to Besra et al [7] and Nayak et al [8], POH is associated with women, whereas Zawar et al [9] found that POH is associated with obesity in women. The limited number of patients included in this research, as well as the fact that the control group was chosen to be age and gender matched, may explain our findings.…”