Periosteal expansion of rabbit mandible with an osmotic self-inflatable expander

Abstract

We aimed to evaluate a new technique for intraoral expansion of soft tissue with a self-inflatable expander in rabbits. We placed a self-inflatable soft tissue expander bilaterally in eight rabbits under the periosteum of the mandible through an extraoral approach. The expander was left to self-inflate for two weeks, after which the animals were killed and specimens collected for histological examination. The self-inflatable soft tissue expanders expanded the periosteum. There were no dehiscences or infections. Histological observations showed no signs of any inflammatory reaction and there was no evidence of bony resorption. New bone had formed at the edges of the expanded periosteum. In the control area no new bone had formed. The osmotic soft tissue expander model for intraoral soft tissue and periosteal expansion suggests a promising way of creating a surplus of soft tissue that can be used to cover bone grafts.

Semipermanent Volumization by an Absorbable Filler

“…The perichondrium has the potential for chondrogenesis, 18 and after hematoma formation (perichondrium detachment from the cartilage), activated perichondrium-resident stem cells may fill the dead space with chondrogenesis, fibrosis, and/or ossification. Secondly, new bone formation at the edge of a tissue expander was experimentally demonstrated in rabbits, 19 and this bone formation was induced by activated periosteal stem cells in the elevated periosteum. We also confirmed the presence of osteogenesis at the edge of a tissue expander after human scalp expansion (Fig.…”

In vivo Manipulation of Stem Cells for Adipose Tissue Repair/Reconstruction

“…Cauliflower ear (wrestler's ear) is a result of chondroneogenesis after hematoma between the auricular cartilage and skin, while osteogenesis is frequently seen at the edge of a tissue expander after scalp expansion [47]. In these cases, new tissue is generated between the perichondrium and cartilage or the periosteum and bone, respectively.…”

The Use of Self-Inflating Soft Tissue Expanders Prior to Bone Augmentation of Atrophied Alveolar Ridges

“…In vitro studies have demonstrated constant expansion rates, achieving increases of up to 30 times the original size . Subsequent animal studies have demonstrated that self‐inflating expanders can create a surplus of soft tissue, facilitating coverage of bone grafts . Additionally, a higher microvessel density in the surrounding soft tissue is described, thus promoting faster osseointegration…”