Periostin, a novel biomarker of TH2-driven asthma

Parulekar, Amit; Atik, Mustafa A.; Hanania, Nicola A.

doi:10.1097/mcp.0000000000000005

Cited by 86 publications

(60 citation statements)

References 49 publications

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“…Nowadays, it is well recognized that the thickening of the epithelial-connective tissue interface in asthma is the consequence of excessive deposits of collagen types I, III, and V, associated to fibronectin and tenascin-C. Periostin identification in the same location as these extracellular matrix protein supports the assertion that they represent different components of the bronchial subepithelial fibrosis [9,16]. These initial observations have been later completed by other studies which revealed an increased periostin serum or sputum level in patients with allergic bronchial asthma [12,17,18]. Thus, an increased periostin level associated with eosinophilia and Th2 mediated inflammation is seen in a specific type of bronchial asthma.…”

Section: Periostin and Bronchial Asthmasupporting

confidence: 59%

Periostin in bronchial asthma – a brief update

Grigoraș¹,

Lozneanu²,

Grigoraş³

et al. 2017

Arch Clin Cases

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Periostin is an extracellular matrix protein which intervenes in the regulation of angiogenesis, and in tumoral cells proliferation and invasion. Recent studies, mainly experimental models, have demonstrated the intervention of this molecule in asthmatic disease, by eosinophils recruitment, bronchial wall remodeling, and by stimulation of inflammatory cytokines production. Currently, periostin is considered a marker of type 2 inflammation in asthma, being secreted by respiratory epithelial cells triggered by IL-13 and IL-4. Concomitantly, periostin accumulated at the bronchial epithelial-connective tissue interface is involved in fibrogenesis and mucus secretion, in correlation with the intensity of bronchial mucosa eosinophilic inflammatory infiltrate. However, the intimate molecular mechanisms of periostin involvement in the pathogenic pathway of asthmatic diseases is far away from elucidation, further research being necessary to certify its value as a biomarker useful in diagnosis and in establishment of therapeutic schemes in bronchial asthma.

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Section: Periostin and Bronchial Asthmasupporting

confidence: 59%

Periostin in bronchial asthma – a brief update

Grigoraș¹,

Lozneanu²,

Grigoraş³

et al. 2017

Arch Clin Cases

View full text Add to dashboard Cite

show abstract

“…Periostin clearly plays crucial roles in tissue repair. However, in some cases, chronic or superabundant periostin expression can accelerate pathogenesis of tumours (22,23), bronchial asthma (24,25), atopic dermatitis (26,27), polycystic kidney disease, and other fibrotic diseases (28). As recently reported, periostin promotes chronic inflammation by activating nuclear factor kappa B (NF-ĸB) signaling (26,29,30).…”

Section: Discussionmentioning

confidence: 99%

Influence of IL13 on Periostin Secretion by Synoviocytes in Osteoarthritis

Moue

Tajika

Ishikawa

et al. 2017

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“…There was also no difference between periostin values of women in early pregnancy (first and second trimester) and women in late pregnancy (third trimester) neither in the AP nor in the HP group (p > 0.05). ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 13 We could not detect any association between periostin, CRP or IL-6 levels and obstetrical data such as gestational age at delivery and fetal birth weight.…”

Section: Relationship Of Inflammatory and Functional Parameters To Obmentioning

confidence: 42%

“…In the recent years, periostin has emerged as a valuable biomarker in asthma, primarily in its T helper 2 (Th2)-induced, eosinophil-predominant phenotype [13]. Periostin is an extracellular matrix protein, which is expressed at low levels in connective tissue and plays a role in generation of collagen.…”

Section: Introductionmentioning

confidence: 99%

Circulating periostin level in asthmatic pregnancy

et al. 2016

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Objective: Asthma often complicates pregnancy and represents a risk for complications.Periostin is considered as a biomarker of asthma; however, as it also plays a role in normal gestation, pregnancy may influence circulating periostin levels. This is the first study assessing periostin in asthmatic pregnancy.Methods: Plasma periostin levels were investigated in asthma (asthmatic non-pregnant, ANP; N = 19) and asthmatic pregnancy (AP; N = 14), compared to healthy non-pregnant controls (HNP; N = 12) and healthy pregnant women (HP; N = 17). The relationship between periostin levels and asthma control determinants was also evaluated. The diagnostic efficacy of periostin to detect uncontrolled asthma was analyzed using ROC analysis. (54.02 [44.30-74.94] ng/mL, p = 0.0346 vs. ANP). Periostin levels of the two pregnant groups were similar (p > 0.05). In AP women periostin correlated negatively with FEV 1 (r = -0.5516) and positively with Raw (r = 0.5535; both p < 0.05).Conclusions: Pregnancy itself increases circulating periostin levels and this elevation is detectable in asthmatic pregnancy as well. Although periostin correlates with lung function in asthmatic pregnancy, periostin as a biomarker has to be handled with caution in pregnant patients due to the influence of pregnancy on its plasma level.

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Periostin, a novel biomarker of TH2-driven asthma

Cited by 86 publications

References 49 publications

Periostin in bronchial asthma – a brief update

Periostin in bronchial asthma – a brief update

Influence of IL13 on Periostin Secretion by Synoviocytes in Osteoarthritis

Circulating periostin level in asthmatic pregnancy

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