Periostin attenuates tumor growth by inducing apoptosis in colitis-related colorectal cancer

Abstract

Inflammatory bowel diseases, which are multifactorial autoimmune colitis diseases, are occurring with increasing prevalence. One of the most serious complications of these diseases is colorectal cancer. Here we investigated the role of periostin (Postn), a matricellular protein that interacts with various integrin molecules on the cell surface, in colitis-induced colorectal cancer. Immunohistochemistry of mouse and human colorectal cancer samples revealed that Postn was expressed in the stroma and was upregulated in close proximity to the cancer cells. The colonic tumorigenesis in an inflammation-related colon carcinogenesis mouse model was increased in Postn knock-out (Postn−/−) mice compared to Postn+/+ mice. Although no difference was found in the degree of colitis between Postn+/+ and Postn−/− mice, Postn inhibited tumor growth and induced the apoptosis of mouse rectal cancer cells in vitro. Furthermore, fewer apoptotic colorectal cancer cells were observed in Postn−/− than in Postn+/+ mice. These data suggested that Postn has an anti-tumor effect on colitis-induced colorectal cancer.

Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation

“…Our previous study demonstrates that periostin can promote liver metastasis of CRC (Bao et al, 2004). However, the roles of periostin in CAC development remain controversial (Shimoyama et al, 2018;Koh et al, 2019), and the underlying molecular mechanisms are still largely unknown. Here, we applied an AOM/DSS-induced inflammation-associated CRC model and an Apc Min/+ spontaneous intestinal tumor model to investigate the role of periostin in colorectal tumor development.…”

Candida utilis yeast as a functional protein source for Atlantic salmon (Salmo salar L.): Local intestinal tissue and plasma proteome responses

“…Periostin is a matricellular protein, belonging to the fasciclin family, that are also defined as an extracellular matrix protein that binds to cell-surface receptors [41]. This protein is an emerging biomarker reflecting type 2 inflammation in allergic diseases in humans [42], and it has also been suggested that periostin mediates intestinal inflammation in mice [43] and promote tumorigenesis in humans [44]. In both SBM and SBM200CU diet the expression of kininogen-1 is decreased.…”

Periostin in Angiogenesis and Inflammation in CRC—A Preliminary Observational Study

“…Periostin has the ability to bind integrins which initiate cross-talk between the integrins and receptor tyrosine kinases such as EGF at the plasma membrane. These connections lead to the activation of the serine threonine Akt and Erk cell signaling pathway, which modulates cell motility, proliferation and survival [17].…”

“…The levels of several pro-inflammatory cytokines are elevated in colorectal cancer [14,16]. Shimoyama Y. et al suggested that periostin has an anti-tumor effect on colitis-induced colorectal cancer [17]. Elliott et al proved that the expression of periostin is related to an inflammatory microenvironment and the presence of TNFα in human chronic wounds [18].…”

“…The proangiogenic activity of periostin is reported in gliomas, breast cancer, pancreatis cancer and liver metastases in CRC; however, in primary colorectal cancer, it has been poorly investigated [6,[16][17][18]. In breast cancer the endothelial tip cells deliver periostin, thus contributing to the development of the perivascular niche [21,24].…”