Periostin concentrations in childhood-onset craniopharyngioma patients

Heinks, Kerstin; Schutter-Nüsse, Caroline De; Boekhoff, Svenja; Bogusz, Agnieszka; Zhu, Jinzhou; Peng, Junxiang; Müller, Hermann L.

doi:10.1007/s40618-018-0987-9

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…Some authors found higher mortality rates among females (24), whereas others did not observe any gender differences in terms of survival (28). Late mortality rates are associated with tumor and/ or treatment-related risk factors such as cerebrovascular disease, progressive disease with multiple recurrences, chronic neuroendocrine deficiencies (26,27,30,31,32,33) and non-alcoholic fatty liver disease (NAFLD) leading to liver cirrhosis (26,27,34,35,36). The standardized overall mortality rate varied from 2.88 to 9.28 in cohort studies performed by Erfurth et al The authors report that CP patients have a 3 to 19-fold increased cardiovascular mortality rate when compared with the general population.…”

Section: Survival and Late Morbiditymentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Childhood-onset craniopharyngioma: state of the art of care in 2018

Müller

2019

European Journal of Endocrinology

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This review presents an update on current concepts of pathogenesis, diagnostics, multidisciplinary treatment and follow-up care, with special focus on neuropsychological sequelae of childhood-onset craniopharyngioma (CP) based on most recent publications on these topics. Recent insight in molecular pathogenesis of CP opens new perspectives on targeted therapy. Further research to elucidate pathogenic mechanisms and to prevent hypothalamic involvement of CP is warranted. Surgical treatment strategies should be based on a multidisciplinary approach involving experienced teams aiming at posterior hypothalamus-sparing treatment for prevention of quality of life impairments. Centralization of CP treatment in experienced ‘centers of excellence’ is recommended. However, such centralization includes high thresholds concerning infrastructure not achievable in all health systems. Alternatives such as multicenter-based networks used for reference assessments should be considered to assure high standards of treatment quality. Irradiation is efficient in preventing further growth or recurrence in CP patients with residual tumor. Proton beam therapy – available on a wider range in the near future – will help to avoid radiooncological side effects. Novel insights into neuropsychological sequelae after CP should be the basis for the development of future therapeutic neuropsychological interventions. Due to the rareness of the disease, common international efforts in research and treatment are recommended and should lead to an international registry for childhood-onset CP, as a first step toward efficient coordination of scientific and clinical initiatives.

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Section: Survival and Late Morbiditymentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Childhood-onset craniopharyngioma: state of the art of care in 2018

Müller

2019

European Journal of Endocrinology

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“…Sample size was estimated based on available literature on periostin with statistical power 0.8, p = 0.05, and effect size 0.55 should be ~50 [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. Fifty pediatric patients with PH were recruited to this single-center cross-sectional study from patients hospitalized in a pediatric nephrology center between February 2018 and March 2019.…”

Section: Methodsmentioning

confidence: 99%

Serum Periostin as a Potential Biomarker in Pediatric Patients with Primary Hypertension

Szyszka

Skrzypczyk

Stelmaszczyk-Emmel

et al. 2021

JCM

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Experimental studies suggest that periostin is involved in tissue repair and remodeling. The study aimed to evaluate serum periostin concentration as potential biomarker in pediatric patients with primary hypertension (PH). We measured serum periostin, blood pressure, arterial damage, biochemical, and clinical data in 50 children with PH and 20 age-matched healthy controls. In univariate analysis, children with PH had significantly lower serum periostin compared to healthy peers (35.42 ± 10.43 vs. 42.16 ± 12.82 [ng/mL], p = 0.038). In the entire group of 70 children serum periostin concentration correlated negatively with peripheral, central, and ambulatory blood pressure, as well as with aortic pulse wave velocity (aPWV). In multivariate analysis, periostin level significantly correlated with age (β = −0.614, [95% confidence interval (CI), −0.831–−0.398]), uric acid (β = 0.328, [95%CI, 0.124–0.533]), body mass index (BMI) Z-score (β = −0.293, [95%CI, −0.492–−0.095]), high-density lipoprotein (HDL)-cholesterol (β = 0.235, [95%CI, 0.054–0.416]), and triglycerides (β = −0.198, [95%CI, −0.394–−0.002]). Neither the presence of hypertension nor blood pressure and aPWV influenced periostin level. To conclude, the role of serum periostin as a biomarker of elevated blood pressure and arterial damage in pediatric patients with primary hypertension is yet to be unmasked. Age, body mass index, uric acid, and lipid concentrations are key factors influencing periostin level in pediatric patients.

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“…La morbilidad a largo plazo está asociada con factores del comportamiento del tumor o por el tratamiento, tales como enfermedad progresiva con recurrencias múltiples, enfermedad cerebrovascular, como dilataciones fusiformes de la arteria carótida 22 y deficiencias neuroendocrinas crónicas 20,21,[23][24][25] . En el CF se ha informado hígado graso no alcohólico, que conduce a cirrosis hepática, secundaria a obesidad hipotalámica mórbida 20,21,[26][27][28] .…”

Section: Supervivencia Y Morbilidadunclassified

Craneofaringioma en pediatría: Diagnóstico y tratamiento

Cabrera-Bernal¹

2020

Rev.Col.Hematol.Oncol

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Los craneofaringiomas (CF) son tumores raros de baja malignidad histológica, que surgen a lo largo del conducto craneofaríngeo. Los dos subtipos histológicos, craneofaringioma adamantinomatoso (CFA) y papilar (CFP), difieren en su origen y distribución por edad. Los CFA se diagnostican con un pico de incidencia bimodal (5–15 años y 45–60 años), mientras que los CFP se presentan exclusivamente en adultos, principalmente en la quinta y sexta décadas de la vida. Los CFA son generados por mutaciones somáticas en CTNNB1, codificador de β-catenina y son predominantemente de aspecto quístico. Los CFP albergan mutaciones somáticas en BRAF V600E y son típicamente tumores sólidos. Las manifestaciones clínicas de hipertensión endocraneana, compromiso visual o deficiencias endocrinas, sirven de alerta para solicitar imágenes. El tratamiento comprende generalmente neurocirugía y radioterapia (RT); la quimioterapia intraquística se usa en el CFA monoquístico. Aunque la supervivencia a largo plazo es alta, con frecuencia se ven afectadas la calidad de vida y la función neuropsicológica, debido a la proximidad anatómica al quiasma óptico, el hipotálamo y la glándula pituitaria. La afectación hipotalámica por el tumor y las lesiones secundarias al tratamiento, con frecuencia resultan en obesidad hipotalámica y déficits neuropsicosociales.

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Periostin concentrations in childhood-onset craniopharyngioma patients

Cited by 7 publications

References 20 publications

MANAGEMENT OF ENDOCRINE DISEASE: Childhood-onset craniopharyngioma: state of the art of care in 2018

MANAGEMENT OF ENDOCRINE DISEASE: Childhood-onset craniopharyngioma: state of the art of care in 2018

Serum Periostin as a Potential Biomarker in Pediatric Patients with Primary Hypertension

Craneofaringioma en pediatría: Diagnóstico y tratamiento

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