Periostin normalizes levels of cardiac markers in rats with experimental isoproterenol cardiotoxicity

Devrim, Alparslan Kadir; Sözmen, Mahmut; Devrim, Tuba; Sudağıdan, Mert; Çınar, Miyase; Kabak, Yonca Betil

doi:10.4149/bll_2017_133

Cited by 6 publications

(10 citation statements)

References 20 publications

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“…Periostin was found to be involved in tissue repair after vascular injury, e.g., in acute rheumatic fever [ 28 ], hypertensive nephropathy [ 19 ], myocardial infarction [ 47 ], and subarachnoid hemorrhage [ 48 ]. Periostin plays a critical role in the interaction with signaling proteins such as NF-kB (nuclear factor kappa B) or STAT3 (signal transducer and activator of transcription) to modulate the response of the extracellular matrix in various tissue pathologies [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Lu et al found that overexpression of periostin in obese rats resulted in liver steatosis and hypertriglyceridemia via activation of c-Jun N-terminal kinase (JNK) signaling pathway and downregulation of peroxisome proliferator-activated receptor alpha (PPARα) [ 60 ]. On the other hand, a recent interventional study in rats after myocardial infarction showed a beneficial effect of periostin supply on HDL-cholesterol [ 47 ]. These experimental results suggest the positive impact of the studied particle on the regulation of cholesterol and triglycerides levels.…”

Section: Discussionmentioning

confidence: 99%

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Serum Periostin as a Potential Biomarker in Pediatric Patients with Primary Hypertension

Szyszka

Skrzypczyk

Stelmaszczyk-Emmel

et al. 2021

JCM

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Experimental studies suggest that periostin is involved in tissue repair and remodeling. The study aimed to evaluate serum periostin concentration as potential biomarker in pediatric patients with primary hypertension (PH). We measured serum periostin, blood pressure, arterial damage, biochemical, and clinical data in 50 children with PH and 20 age-matched healthy controls. In univariate analysis, children with PH had significantly lower serum periostin compared to healthy peers (35.42 ± 10.43 vs. 42.16 ± 12.82 [ng/mL], p = 0.038). In the entire group of 70 children serum periostin concentration correlated negatively with peripheral, central, and ambulatory blood pressure, as well as with aortic pulse wave velocity (aPWV). In multivariate analysis, periostin level significantly correlated with age (β = −0.614, [95% confidence interval (CI), −0.831–−0.398]), uric acid (β = 0.328, [95%CI, 0.124–0.533]), body mass index (BMI) Z-score (β = −0.293, [95%CI, −0.492–−0.095]), high-density lipoprotein (HDL)-cholesterol (β = 0.235, [95%CI, 0.054–0.416]), and triglycerides (β = −0.198, [95%CI, −0.394–−0.002]). Neither the presence of hypertension nor blood pressure and aPWV influenced periostin level. To conclude, the role of serum periostin as a biomarker of elevated blood pressure and arterial damage in pediatric patients with primary hypertension is yet to be unmasked. Age, body mass index, uric acid, and lipid concentrations are key factors influencing periostin level in pediatric patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum Periostin as a Potential Biomarker in Pediatric Patients with Primary Hypertension

Szyszka

Skrzypczyk

Stelmaszczyk-Emmel

et al. 2021

JCM

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“…A total of 30 male, 10 weeks old BALB/c mice (Kobay Inc, TR) weighing 30 ± 3.59 g were randomly divided into three groups, each consisting of 10 mice. The conditions of the cage environment, care, and feeding of the animals were designed as previously reported (9).…”

Section: Animals and Husbandrymentioning

confidence: 99%

“…The obtained homogenates were centrifuged at 3000 rpm for 5 minutes at +4 °C. Oxidative stress parameters were measured in supernatants formed after a centrifugation (9). The levels of Total Antioxidant Status (TAS) and Total Oxidant Status (TOS) in liver and kidney tissue homogenates were measured spectrophotometrically (MultiskanGO, Thermo, USA) using the methods described in the kits (Rel Assay Kit Diagnostics, TR).…”

Section: Biochemical Analysismentioning

confidence: 99%

“…The levels of Total Antioxidant Status (TAS) and Total Oxidant Status (TOS) in liver and kidney tissue homogenates were measured spectrophotometrically (MultiskanGO, Thermo, USA) using the methods described in the kits (Rel Assay Kit Diagnostics, TR). Results were expressed in mmol Trolox equiv./lt for TAS and μmol H 2 O 2 equiv./lt for TOS (9). In addition, the oxidative stress index (OSI), expressed as a percentage of the ratio of TOS levels to TAS levels, was also calculated and the results were expressed in the arbitrary unit (AU) (10).…”

Section: Biochemical Analysismentioning

confidence: 99%

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Late effects of cutaneous 3-methylcholanthrene exposure on DNA damage-related pleiotropic growth factors and oxidative stress markers in mice

Devrim¹,

Ekici²,

Devrim³

et al. 2020

BLL

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BACKGROUND: Skin is the body's fi rst defence against direct exposure to variety of chemicals. Polycyclic aromatic hydrocarbons such as 3-methylcholanthrene (3-MC) are common in polluted urban air and have a potential of producing harmful effects. Moreover, their late effects can occur months or years after exposure. OBJECTIVES: We aimed to investigate the long-term effects of 3-MC induced dermal toxicity on the expression of markers of apoptosis, pleiotropic cytokines, and oxidative stress and to determine the protective effect of cisplatin. METHODS: Groups were designed as control (group 1), 3-MC applied (group 2) and 3-MC+cisplatin applied mice (group 3). Cutaneous expressions of TGFβ, PDGFA, PDGFC, bFGF, PDGFRα, USP28, and Ki67 were evaluated with qPCR. Total oxidant (TOS), total antioxidant (TAS) and oxidative stress index (OSI) values were determined in liver and kidney tissues. RESULTS: The expression levels of TGFβ, PDGFRα, USP-28, Ki67, and PDGFA were decreased signifi cantly in MC applied groups. Renal TAS levels were signifi cantly lower in group-3. Liver and kidney OSI values were increased in both groups 2 and 3. CONCLUSION: The results indicated that low dose 3-MC caused oxidative stress and downregulated apoptotic and cytokine markers in the long term and cisplatin had no ameliorative effects on this degeneration processes (Tab.

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Upregulation of Periostin Through CREB Participates in Myocardial Infarction-induced Myocardial Fibrosis

Xue

Chen

Chai

et al. 2022

Journal of Cardiovascular Pharmacology

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Myocardial fibrosis after myocardial infarction (MI) leads to heart failure, which has become an important global public health issue. One of the most important features of myocardial fibrosis is the abnormal deposition of extracellular matrix (ECM) proteins. Periostin is one of the ECM proteins. Cyclic AMP response element-binding protein 1 (CREB) is well known for its involvement in multiple signaling in myocardial fibrosis. It has been confirmed that CREB could regulate ECM proteins deposition. However, little is known about the relationship between CREB and periostin post-MI. This study aims to verify the hypothesis that CREB promotes the expression of periostin in MI-induced myocardial fibrosis. To test this hypothesis, primary rat cardiac fibroblasts were cultured and rat model of MI was established. The level of myocardial fibrosis post-MI was identified by histological staining. The expressions of CREB and periostin were detected through western blot and reverse transcription quantity polymerase chain reaction. The upregulation and downregulation of CREB and periostin were established by plasmid, small interfere RNA (siRNA), and lentivirus, respectively. High levels of CREB and periostin were found post-MI in our study. Meanwhile, the expression of periostin was decreased after CREB downregulation both in vivo and in vitro. Finally, with the treatment of pAV-CREB and si-periostin, the expressions of collagen Ⅰ and Ⅲ were attenuated. The expression of periostin was elevated post-MI and participated in MI-induced myocardial fibrosis, which was regulated through CREB. This study provides a novel idea and potential intervention target for MI-induced myocardial fibrosis.

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Periostin normalizes levels of cardiac markers in rats with experimental isoproterenol cardiotoxicity

Abstract: It is concluded that periostin could have a potential to increase the rate of myocardial recovery after myocardial infarction (Tab. 5, Ref. 28).

Cited by 6 publications

References 20 publications

Serum Periostin as a Potential Biomarker in Pediatric Patients with Primary Hypertension

Serum Periostin as a Potential Biomarker in Pediatric Patients with Primary Hypertension

Late effects of cutaneous 3-methylcholanthrene exposure on DNA damage-related pleiotropic growth factors and oxidative stress markers in mice

Upregulation of Periostin Through CREB Participates in Myocardial Infarction-induced Myocardial Fibrosis

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