Peripapillary choroidal thickness in glaucoma measured with optical coherence tomography

Ehrlich, Joshua R.; Peterson, Jeffrey; Parlitsis, George; Kay, K. Y.; Kiss, Szilárd; Radcliffe, Nathan M.

doi:10.1016/j.exer.2011.01.002

Cited by 92 publications

(97 citation statements)

References 36 publications

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“…By contrast, other authors did not find increased choroidal thickness in glaucomatous eyes measured by Spectralis OCT [17,18,19]. Similarly, Ehrlich et al [20] did not find a significant difference in peripapillary choroidal thickness in patients with and without open-angle glaucoma using SD-OCT. In agreement with previous investigations [1,2,16,21,22,23,24], we found increased choroidal thickness in glaucomatous eyes versus healthy eyes, which was probably due to vascular events in the uvea that caused the open-angle glaucoma.…”

Section: Discussionmentioning

confidence: 89%

Choroidal Thickness in Open-Angle Glaucoma Measured by Spectral-Domain Scanning Laser Ophthalmoscopy/Optical Coherence Tomography

et al. 2012

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Aims: To measure macular choroidal thickness in healthy and glaucomatous eyes using spectral-domain scanning laser ophthalmoscopy/optical coherence tomography. Methods: Choroidal thickness was measured in 21 healthy eyes and 16 glaucomatous eyes. Choroidal thickness was measured under the fovea and at 500-µm intervals from the foveal center to 4 mm in the nasal and temporal directions. Vessels were counted in a macular area of 8,000 µm². Only choroidal vessels with a horizontal diameter of at least 155 µm and a vertical diameter of at least 50 µm were considered. Results: The mean choroidal thickness was greatest below the fovea, i.e. 343.8 µm (SD ±29.06) in controls and 411.56 µm (SD ±33.60; p < 0.001) in the glaucomatous group. The mean vertical diameter was significantly greater (p = 0.008) in glaucomatous eyes (112.18 ± 37.64 µm) than in healthy eyes (103.98 ± 25.67 µm), whereas the luminal area of vessels was significantly larger (p = 0.3) in glaucomatous eyes (39,157.34 ± 21,657.23 µm²) than in healthy eyes (43,779.84 ± 22,874.87 µm²). Conclusions: We show that choroidal thickness is increased in glaucomatous eyes due to an increase in both the vertical diameter and the luminal area of the vessels. This seems to implicate the choroid in the pathogenesis of open-angle glaucoma.

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Section: Discussionmentioning

confidence: 89%

Choroidal Thickness in Open-Angle Glaucoma Measured by Spectral-Domain Scanning Laser Ophthalmoscopy/Optical Coherence Tomography

et al. 2012

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“…For example, Jiang et al [29] reported no association between glaucoma and PPCT using SD-OCT with a 360° 3.4-mm scan circle centered on the ONH. Other authors, such as Ehrlich et al [13] , reported no association between RNFL thickness and PPCT in a cohort of patients that included POAG patients and glaucoma suspects. Previous meta-analyses conducted by Wang and Zhang [30] and Zhang et al [31] showed no correlation between PPCT and POAG, but both only included studies using enhanced depth imaging OCT technology and not SS-OCT.…”

Section: Discussionmentioning

confidence: 92%

“…The choroid is a dynamic structure, and its thickness depends on several factors, e.g., a thinner choroid is associated with older age [13,23] , higher IOP [24] , higher myopia, and longer axial length [25,26] . Several factors contribute to the conflicting findings using OCT regarding the PPCT in glaucoma, including different measurement techniques (most of them are performed manually), and the dynamic and variable nature of the choroid [27] .…”

Section: Discussionmentioning

confidence: 99%

“…Some authors reported a reduction in the mean or regional peripapillary choroidal thickness (PPCT) in primary open-angle glaucoma (POAG), especially in association with sclerotic optic disk damage [9] and normal tension glaucoma [10,11] . Others found no differences among glaucoma, healthy, and glaucoma-suspect eyes with regard to peripapillary choroidal structures [12,13] . Most of these studies, however, have critical limitations.…”

Section: Introductionmentioning

confidence: 97%

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Peripapillary Choroidal Thickness Analysis Using Swept-Source Optical Coherence Tomography in Glaucoma Patients: A Broader Approach

et al. 2017

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Aims: To evaluate and compare peripapillary choroidal thickness (PPCT) in a wide area around the optic disk and various choroidal established zones in healthy controls and primary open-angle glaucoma (POAG) patients using a new swept-source (SS) optical coherence tomography (OCT) device. Methods: A total of 246 eyes were finally included in this observational, prospective, cross-sectional study: 111 healthy controls and 135 POAG patients. The healthy subjects were divided into 2 populations: the teaching population (25 used to establish choroidal zones) and the validating population (86 used for comparing choroidal thickness with POAG patients). A 26 × 26 cube grid centered on the optic disk was generated using an SS-OCT to automatically measure choroidal thickness. Four choroidal zones were established and used to compare PPCT between healthy controls and POAG patients. Results: PPCT was significantly thinner in zones 3 and 4 of the POAG group. The choroid exhibited a similar pattern in controls and patients with POAG; it was thickest in the superior region, followed in order by the temporal, nasal, and inferior regions. Conclusions: Peripapillary choroidal tissue shows a concentric pattern in both groups, and glaucoma patients present with peripapillary choroidal thinning compared with healthy subjects, especially in areas further away from the optic disk.

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“…Für die pAD speziell wurde eine Assoziation mit dem diastolischen Blutdruck [7], der Achsenlänge, der zentralen Hornhautdicke [7], dem Lebensalter [12,13] und dem Papillenabstand [14] nachgewiesen. Die pAD ist im inferioren Bereich [14] (infero-nasal, inferior und infero-temporal [13,15]) signifikant dünner als in den anderen peripapillären Lokalisationen.…”

Section: Hintergrundunclassified

Korrelation von peripapillärer Aderhautdicke und primärem Offenwinkelglaukom

Zimmermann¹,

Plöger

Kramm

et al. 2015

Spektrum Augenheilkd.

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ZusammenfassungHintergrund Vaskuläre Theorien zur Pathogenese des primären Offenwinkelglaukoms (POWG) und zur papillären Blutversorgung lassen Veränderungen der peripapillären Aderhaut bei POWG vermuten. Die prospektive Studie vergleicht die peripapilläre Aderhautdicke (pAD) bei POWG mit Augengesunden.Material und Methoden Die pAD wurde mittels SD-OCT in 300, 600 und 900 μm Abstand zur Papille für 12 Halbmeridiane bestimmt. An der Studie nahmen 15 Probanden mit POWG (kaukasisch, Alter 65,7 ± 10,6 Jahre) und 9 augengesunde Probanden (kaukasisch, Alter 59,4 ± 14,7 Jahre) teil.Resultate In Augen mit POWG war die pAD um durchschnittlich 15,2 % (89,0 ± 34,4 versus 105,4 ± 26,8 μm, p < 0,001) reduziert. Der Unterschied zum Normalauge wird mit zunehmendem Abstand zur Papille geringer: 300 µm: 20,5 % (77,9 ± 33,7 versus 98,0 ± 25,0 μm, p = 0,002), 600 µm: 12,9 % (93,2 ± 32,6 versus 107,0 ± 27,3 μm, p = 0,002), 900 µm: 12,7 % (97,2 ± 32,4 versus 111,3 ± 26,4 μm, p = 0,002). In Bezug auf die Halbmeridiane waren in den verschiedenen Papillenabständen im nasalen Bereich signifikante Unterschiede der pAD nachweisbar. Nach Bonferroni-Holm-Korrektur ist keine Signifikanz der pAD-Unterschiede mehr vorhanden (p > 0,05 für alle Halbmeridiane).Schlussfolgerung Bei Patienten mit POWG ist die pAD signifikant reduziert. Das Ergebnis unterstützt die vaskuläre Theorie für die Pathogene des POWG. In zukünftigen Studien gilt es herauszuarbeiten, ob die Reduktion der Aderhautdicke bei verschiedenen Glaukomformen gleichermaßen auftritt und inwieweit die Aderhautdicke von systemischen Erkrankungen beeinflusst wird.Schlüsselwörter Peripapilläre Aderhautdicke · Spectral-Domain Optische Kohärenz Tomographie · Primär chronisches Offenwinkelglaukom · Glaukompathogenese · Perfusionsstörung Correlation of peripapillary choroidal thickness and primary open angle glaucoma SummaryBackground Vascular theories of pathogenesis of primary open angle glaucoma (POAG) and of papillary blood supply suggest changes of the peripapillary choroid by POAG. This prospective study compares the peripapillary choroidal thickness (PCT) in POAG with normal eyes.Material and methods PCT was measured by SD-OCT in 300, 600 and 900 μm distance from the papilla, for 12/2 meridians determined. The study involved 15 subjects with POAG (caucasian, age 65.7 ± 10.6 years) and 9 subjects without POAG part (caucasian, age 59.4 ± 14.7 years).Results POAG-subjects showed a reduction by an average PCT of 15.2 % (89.0 ± 34.4 versus 105.4 ± 26.8 microns, p < 0.001). The difference to normal subjects decreases with increasing distance from the papilla: 300 μm: 20.5 % (77.9 ± 33.7 versus 98.0 ± 25.0 μm, p = 0.002), 600 μm: 12.9 % (93.2 ± 32.6 versus 107.0 ± 27,3 μm, p = 0.002), 900 μm: 12.7 % (97.2 ± 32.4 versus 111.3 ± 26.4 μm, p = 0.002). Regarding the half-meridians, significant diforiginalarbeit Korrelation von peripapillärer Aderhautdicke und primärem Offenwinkelglaukom 125 1 3 ferences were detected in the nasal area. There is no significant PCT-difference jusing Bonferroni-Holm-cor...

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Peripapillary choroidal thickness in glaucoma measured with optical coherence tomography

Cited by 92 publications

References 36 publications

Choroidal Thickness in Open-Angle Glaucoma Measured by Spectral-Domain Scanning Laser Ophthalmoscopy/Optical Coherence Tomography

Choroidal Thickness in Open-Angle Glaucoma Measured by Spectral-Domain Scanning Laser Ophthalmoscopy/Optical Coherence Tomography

Peripapillary Choroidal Thickness Analysis Using Swept-Source Optical Coherence Tomography in Glaucoma Patients: A Broader Approach

Korrelation von peripapillärer Aderhautdicke und primärem Offenwinkelglaukom

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