Peripapillary hyperreflective ovoid mass-like structures (PHOMS) in children

Ahn, Ye Jin; Park, Yoo Yeon; Shin, Sun Young

doi:10.1038/s41433-021-01461-w

Cited by 16 publications

(27 citation statements)

References 24 publications

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“…PHOMS do not correspond to clinically visible ODD. The same OCT findings can also be seen in patients without ODD (16).…”

Section: Discussionsupporting

confidence: 72%

“…PHOMS is defined as a hyperreflective ovoid mass-like structure with a hyperreflective interior without sharp outer edges or a hyporeflective core. PHOMS can typically not be found using fluorescence methods, and is not visible on B-scan ultrasonography despite its superficial location ( 16 ). It can also be seen in patients without apparent optic disc edema or poorly demarcated optic discs.…”

Section: Discussionmentioning

confidence: 99%

“…PHOMS were also observed in patients with myopic tilted discs, which is not related to papilledema nor ODD. It is now suggested, PHOMS are non-specific OCT findings of axonal distension and crowding that can be seen in acquired and dysplastic anomalies of the ONH ( 16 ). PHOMS is a new clinical feature found on the EDI-OCT in recent years.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Multi-Mode Imaging Features of Eyes With Peripapillary Hyperreflective Ovoid Mass-Like Structures

et al. 2022

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PurposeTo observe and analyze the clinical and multi-mode imaging features of eyes with PHOMS, and to introduce two cases of PHOMS which underwent multi-mode imaging.MethodsRetrospective clinical observational study. A total of 26 patients (37 eyes) with hyperreflective structures surrounded by hyporeflective edges around the optic discs who were examined and diagnosed at Shandong Eye Hospital between January 2019 and June 2021 were included in the study. Among these patients, 12 were male and 14 were female. Fifteen were monocular. The average age was 39 years. All patients underwent the following examinations: Best-corrected visual acuity (BCVA), intraocular pressure examinations, slit-lamp anterior segment examinations, indirect ophthalmoscopy, visual field examinations, fundus color photography, fundus autofluorescence (FAF), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA). Some of the patients were examined with fundus fluorescein angiography (FFA). Clinical data and imaging characteristics from the OCT, OCTA, and FFA were analyzed retrospectively.ResultsWe found the hyperreflective structures surrounded by hyporeflective edges around the optic discs in 37 eyes. EDI-OCT results revealed hyperreflective structures surrounded by hyporeflective edges around the optic discs in all eyes. Typical hyperreflexia lesions occurred around the optic disc, located subretinally and above Bruch's membrane. OCTA revealed that the highly reflective perioptic material also had vascular structures.ConclusionEDI-OCT of PHOMS showed hyperreflective structures surrounded by hyporeflective edges around all of the optic discs. Infra-red photography showed temporal hyperreflexia. These characteristics can be seen in a variety of diseases and may be a relatively common feature revealed by EDI-OCT scanning. These characteristics may also be seen in elderly patients as well as children. PHOMS may be found in optic disc drusen (ODD), tilted disc syndrome (TDS), optic neuritis, ischemic optic neuropathy, and in white dot syndromes. Few patients may be developed into macular neovascularization (MNV). In order to improve the accuracy and robustness of the conclusions and provide better clinical guidance, we need to conduct more comprehensive research in the subsequent clinical work.

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“…PHOMS do not correspond to clinically visible ODD. The same OCT findings can also be seen in patients without ODD (16).…”

Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

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Clinical and Multi-Mode Imaging Features of Eyes With Peripapillary Hyperreflective Ovoid Mass-Like Structures

et al. 2022

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“…20 It has been suggested that patients with small diameter of BMO present with larger PHOMS. 21 We did not find a correlation between the diameter of BMO and the volume of PHOMS in patients with either buried or visible ODD. The BMO diameter may therefore not significantly affect the formation and volume of PHOMS.…”

Section: Discussioncontrasting

confidence: 62%

Volumetric Measurement of Peripapillary Hyperreflective Ovoid Masslike Structures in Patients with Optic Disc Drusen

Jørgensen

Malmqvist

Hansen

et al. 2022

Ophthalmology Science

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“…We measured the BMO diameter in these latter 14 children and found that 10 of these were in the lowest quartile based on a nested cohort of 130 random subjects measured by Malmqvist et al 15 (see Table 4). A recent study of PHOMS in children 26 found that the BMO in children with PHOMS was significantly smaller than that of controls. Of a total of 45 eyes with PHOMS, 16 eyes had coexisting buried ODD, and there was no report of presence of prelaminar hyperreflective lines.…”

Section: Discussionmentioning

confidence: 89%