Peripapillary retinal nerve fibre layer thinning in genetic generalized epilepsy

Aleja, Jesús González de la; Guerrero-Molina, M.P.; Saiz-Díaz, Rosa Ana; López-Muñoz, Francisco; Raga-Martínez, Isidoro; Hernández-Gallego, Jesús; Navarrete-Chamorro, Patricia; Povedano-Montero, Francisco Javier

doi:10.1016/j.seizure.2019.07.022

Cited by 9 publications

(7 citation statements)

References 39 publications

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“…This prospective OCT study systematically characterized the extent of the retinal changes in a broad range of wellcharacterized adults with epilepsy, revealing a significant retinal neuroaxonal loss across the inner retinal layers (G-pRNFL, mRNFL, GCIP, and INL), as well as a reduced total macula volume. This finding is in line with previous reports on RNFL thinning in adults with epilepsy, [11][12][13][14]16 and complements the few available smaller-scaled studies on GCIP, 11,14,18 and TMV. 18 Besides age as known driver of neuroaxonal loss in epilepsy, 12,16 we identified a significant association between the retinal neuroaxonal loss and the frequency of TCS, as well as the number of ASM.…”

Section: Discussionsupporting

confidence: 93%

“…In PwE, first cross‐sectional OCT evaluations were also promising. They described signs of retinal neuroaxonal loss in adults with epilepsy, 11–13 which correlated with disease duration as well as intellectual disability 12 . Retinal axonal loss was advanced in PwE who proved to be drug‐resistant, received polypharmacotherapy, or were treated with certain antiseizure medications (ASM), namely vigabatrin, ethosuximide, primidone, phenytoin, topiramate, and valproate 12,14–17 .…”

Section: Introductionmentioning

confidence: 99%

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Association between retinal thickness and disease characteristics in adult epilepsy: A cross‐sectional OCT evaluation

Delazer,

Bao,

Lauseker

et al. 2023

Epilepsia Open

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ObjectiveThinning of the peripapillary retinal nerve fiber layer (p‐RNFL), as measured by optical coherence tomography (OCT), was recently introduced as a promising marker for cerebral neuronal loss in people with epilepsy (PwE). However, its clinical implication remains to be elucidated. We thus aimed to (1) systematically characterize the extent of the retinal neuroaxonal loss in a broad spectrum of unselected PwE and (2) to evaluate the main clinical determinants.MethodsIn this prospective study, a spectral‐domain OCT evaluation was performed on 98 well‐characterized PwE and 85 healthy controls (18‐55 years of age). All inner retinal layers and the total macula volume were assessed. Group comparisons and linear regression analyses with stepwise backwards selection were performed to identify relevant clinical and demographic modulators of the retinal neuroaxonal integrity.ResultsPwE (age: 33.7±10.6 years; 58.2% female) revealed a significant neuroaxonal loss across all assessed retinal layers (global pRNFL, p=0.001, Δ=4.24μm; macular RNFL, p<0.001, Δ=0.05mm3; ganglion cell inner plexiform layer, GCIP, p<0.001, Δ=0.11mm3; inner nuclear layer, INL, p=0.03, Δ=0.02mm3) as well as significantly reduced total macula volumes (TMV, p<0.001, Δ=0.18mm3) compared to healthy controls (age: 31.2±9.0 years; 57.6% female). The extent of retinal neuroaxonal loss was associated with the occurrence and frequency of tonic‐clonic seizures and the number of anti‐seizure medications, and was most pronounced in male patients.SignificancePwE presented an extensive retinal neuroaxonal loss, affecting not only the peripapillary but also macular structures. The non‐invasive and economic measurement via OCT bears the potential to establish as a practical tool to inform patient management, as the extent of the retinal neuroaxonal loss reflects aspects of disease severity and sex‐specific vulnerability.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Association between retinal thickness and disease characteristics in adult epilepsy: A cross‐sectional OCT evaluation

Delazer,

Bao,

Lauseker

et al. 2023

Epilepsia Open

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“…In the 2003 study by Viestenz et al [61], vigabatrin, used in epilepsy, was reported to damage the optic nerve. However, subsequent studies showed decreased RNFL thickness in patients without prior exposure to this drug [5,62]. Also in Parkinson's disease, studies suggest that there is a decrease in RNFL [2,63].…”

Section: Discussionmentioning

confidence: 99%

“…The high resolution and different intensities of reflected light allow an almost histological segmentation of the different layers of the retina, as well as other anatomic structures. During the past two decades, OCT technology has been used to evaluate a variety of optic neuropathies, including glaucoma and non-glaucomatous optic neuropathies, as well as other neurodegenerative diseases (NDD) [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Detection of Neurological and Ophthalmological Pathologies with Optical Coherence Tomography Using Retinal Thickness Measurements: A Bibliometric Study

et al. 2020

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We carry out a bibliometric analysis on neurological and ophthalmological pathologies based on retinal nerve fiber layer (RNFL) thickness measured with optical coherence tomography (OCT). Documents were selected from Scopus database. We have applied the most commonly used bibliometric indicators, both for production and dispersion, as Price’s law of scientific literature growth, Lotka’s law, the transient index, and the Bradford model. Finally, the participation index of the different countries and affiliations was calculated. Two-hundred-and-forty-one documents from the period 2000–2019 were retrieved. Scientific production was better adjusted to linear growth (r = 0.88) than exponential (r = 0.87). The duplication time of the documents obtained was 5.6 years. The transience index was 89.62%, which indicates that most of the scientific production is due to very few authors. The signature rate per document was 5.2. Nine journals made up the Bradford core. USA and University of California present the highest production. The most frequently discussed topics on RNFL thinning are glaucoma and neurodegenerative diseases (NDD). The growth of the scientific literature on RNFL thickness was linear, with a very high rate of transience, which indicates low productivity and the presence of numerous authors who sporadically publish on this topic. No evidence of a saturation point was observed. In the last 10 years, there has been an increase in documents relating the decline of RNFL to NDD.

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“…found RNFL (mean, superior, and inferior quadrants) to be significantly thinner in epilepsy patients compared to the control group. [ 18 ] Balestrini et al . found that the mean and four-quadrant RNFL values were significantly lesser in epilepsy patients, and showed that this thinning was associated with drug resistance and duration of epilepsy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of ganglion cell complex and retinal nerve fiber layer thinning in epilepsy patients

Duran¹,

Aykaç

Eliaçık

2023

Indian Journal of Ophthalmology

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Purpose: This study aimed to compare the perimacular ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (RNFL) thickness measurements of epileptic and healthy individuals. Methods: The right eyes of 38 epileptic and 38 healthy individuals who had been using antiepileptic drugs (AEDs) for at least 1 year were included in the study. Central macular thickness, perimacular GCC thickness and volume, and peripapillary retinal nerve fiber layers were measured by optical coherence tomography (OCT) device. Perimacular 1, 3, and 6 mm circle diameters of Early Treatment of Diabetic Retinopathy Study (ETDRS) were selected for GCC measurements. Results: In epilepsy patients, GCC was significantly lower in the 3 mm superior quadrant and 6 mm in all quadrants compared to the control group (P < 0.05). RNFL was significantly thinner in epilepsy patients only in the temporal-inferior quadrant (P < 0.05). There was no significant difference between the patients who received AEDs as monotherapy and polytherapy (P > 0.05). Conclusion: We found that epilepsy patients had significant thinning in the GCC layers and temporal-inferior quadrant of RNFL compared to the control group. Our findings from the study show that early retinal changes in epilepsy patients, especially perimacular GCC layers, can be followed up with OCT.

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Peripapillary retinal nerve fibre layer thinning in genetic generalized epilepsy

Cited by 9 publications

References 39 publications

Association between retinal thickness and disease characteristics in adult epilepsy: A cross‐sectional OCT evaluation

Association between retinal thickness and disease characteristics in adult epilepsy: A cross‐sectional OCT evaluation

Detection of Neurological and Ophthalmological Pathologies with Optical Coherence Tomography Using Retinal Thickness Measurements: A Bibliometric Study

Evaluation of ganglion cell complex and retinal nerve fiber layer thinning in epilepsy patients

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