Peripapillary Versus Macular Combined Hamartoma of the Retina and Retinal Pigment Epithelium: Imaging Characteristics

Gupta, Rajan; Fung, Adrian T.; Lupidi, Marco; Pappuru, Rajeev Reddy; Nayak, Sameera; Sahoo, Niroj Kumar; Kaliki, Swathi; Yannuzzi, Lawrence A.; Reid, Kate; Lim, Li–Anne S; Sacconi, Riccardo; Dave, Vivek Pravin; Singh, Sumit Randhir; Ayachit, Apoorva; Gabrielle, Pierre‐Henry; Cai, Sophie; Lima, Luiz H.; Querques, Giuseppe; Arévalo, J. Fernando; Freund, K. Bailey; Shields, Carol L.; Chhablani, Jay

doi:10.1016/j.ajo.2019.01.016

Cited by 18 publications

(23 citation statements)

References 10 publications

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“…Choroidal neovascularization is a known sequela of CHRRPE and has been described in macular and extramacular lesions. 2 , 3 In all previously reported cases, CNVM secondary to CHRRPE occurs at the border of the lesion or underneath it. 3 , 10 , 11 , 12 To our knowledge, this is the first reported case of remote CNVM associated with CHRRPE.…”

Section: Discussionmentioning

confidence: 97%

“… 2 , 3 In all previously reported cases, CNVM secondary to CHRRPE occurs at the border of the lesion or underneath it. 3 , 10 , 11 , 12 To our knowledge, this is the first reported case of remote CNVM associated with CHRRPE. Owing to the elongated, circumferential orientation of the patient's lesion, tractional forces were exerted radially over a large area of retina leading to dragging of nasal retinal vessels, a dragged disc appearance, and a shallow tractional retinal detachment.…”

Section: Discussionmentioning

confidence: 97%

“… 2 On the basis of the few reported cases, secondary CNVM most often occurs with peripapillary CHRRPE, rather than macular or peripheral lesions. 3 When present, choroidal neovascularization has been reported to occur underneath or at the border of the CHRRPE with variable exudation and hemorrhage. 4 Herein, we report the first known association of CHRRPE with remote CNVM.…”

Section: Introductionmentioning

confidence: 99%

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Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane

Lazzarini¹,

Al-Khersan²,

Patel³

et al. 2020

American Journal of Ophthalmology Case Reports

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Purpose To describe the first reported case of combined hamartoma of the retina and retinal pigment epithelium (CHRRPE) associated with a remote choroidal neovascular membrane (CNVM). Observations A 19-month-old girl with a normal prenatal and infantile history presented with esotropia of the left eye. Fundus examination demonstrated a large, elevated, charcoal-colored lesion in the nasal equatorial retina. There was dragging of the nasal retinal vessels and a retinal fold, presumed to have resulted from nasal traction from the lesion. There was also subretinal hemorrhage in the peripapillary macula. Multimodal imaging demonstrated a peripapillary choroidal neovascular membrane (CNVM) underlying the retinal fold. There was no leakage within the tumor or secondary retinal neovascularization. Examination of the fellow eye was unremarkable. The patient was diagnosed with peripheral CHRRPE with associated peripapillary CNVM. She was treated with serial intravitreal bevacizumab to the affected eye which resulted in a reduction in leakage from the CNVM and resolution of the subretinal hemorrhage. The CHRRPE remained stable on follow-up. Conclusions Peripheral CHRRPE can rarely be associated with a remote CNVM.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane

Lazzarini¹,

Al-Khersan²,

Patel³

et al. 2020

American Journal of Ophthalmology Case Reports

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“…Гамартома часто возникает на фоне системного туберозного склероза (болезнь Бурневиля), реже ее обнаруживают у пациентов с нейрофиброматозом II типа (в меньшей степени I типа), синдромом Горлина, ювенильной назофаренгиальной ангиофибромой. Однако это новообразование может спорадически появляться в изолированном варианте у здоровых людей [2][3][4].…”

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“…На гистологических срезах отмечается тотальная дезорганизация архитектоники ретинальной ткани, сопровождающаяся пролиферацией глии и пигментного эпителия [2]. Основываясь на расположении и клинических проявлениях, Gass классифицировал комбинированную гамартому на четыре группы: папиллярная и юкстапапиллярная (56-76%), макулярная (17-38%) и периферическая (5-7%) [1,4].…”

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Poetapnyy podkhod v lechenii kombinirovannoy gamartomy setchatki i retinal'nogo pigmentnogo epiteliya

Тахчиди¹,

Тахчиди²,

Касмынина³

et al. 2020

Вестник РГМУ

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Kombinirovannaya gamartoma pigmentnogo epiteliya i setchatki — redkoye vrozhdennoye dobrokachestvennoye novoobrazovaniye. Naiboleye chasto yeye vyyavlyayut u molodykh lyudey i podrostkov. V bol'shinstve sluchayev zabolevaniye protekayet bessimptomno, odnako v 24% snizheniye zritel'nykh funktsiy obuslovleno razvitiyem oslozhneniy: epiretinal'nogo fibroza, soprovozhdayushchegosya traktsionnym iskazheniyem fovea, gemoftal'mom, khorioidal'noy neovaskulyarizatsiyey, ekssudativnoy otsloykoy setchatki, makulyarnym otekom, traktsionnoy/regmatogennoy otsloykoy setchatki. V nastoyashcheye vremya ne sushchestvuyet yedinogo mneniya v lechenii oslozhneniy, vyzvannykh kombinirovannoy gamartomoy. Dannyy klinicheskiy sluchay demonstriruyet vozmozhnost' poetapnogo lecheniya kombinirovannoy gamartomy setchatki i retinal'nogo pigmentnogo epiteliya, oslozhnennogo epiretinal'nym fibrozom i chastichnym gemoftal'mom, s ispol'zovaniyem sovremennykh metodov diagnostiki (opticheskaya kogerentnaya tomografiya) i lecheniya.

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Pigmentierter Fundustumor beim Kind

et al. 2020

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Peripapillary Versus Macular Combined Hamartoma of the Retina and Retinal Pigment Epithelium: Imaging Characteristics

Cited by 18 publications

References 10 publications

Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane

Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane

Poetapnyy podkhod v lechenii kombinirovannoy gamartomy setchatki i retinal'nogo pigmentnogo epiteliya

Pigmentierter Fundustumor beim Kind

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