Peripartum cardiomyopathy: challenges and solutions

Scardovi, Angela Beatrice; Maria, Renata De

doi:10.2147/rrcc.s103577

Cited by 5 publications

(9 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Besides the frequency of RV involvement, we note that the clinical profile of the patients in this work is similar to that already reported in the literature, notably as regards the etiological factors such as the age of occurrence around 31.7±6.9 years, multiparity, prevalence of twins, and low socioeconomic status. 2,[11][12][13][14] In addition, there were reports of signs of RV failure, 4,5,11 which were noted in 84% of the patients in this work.…”

Section: Discussionsupporting

confidence: 54%

Prevalence and characteristics of dysfunction of right ventricle in peripartum cardiomyopathy

Fatou¹,

Ndiaye²,

Sarr³

et al. 2017

RRCC

View full text Add to dashboard Cite

Background:The study of the right ventricle (RV) is of particular interest as it is believed to be involved in several heart diseases. Peripartum cardiomyopathy (PPCM) is characterized by left ventricular systolic dysfunction occurring between the last month of pregnancy and the fifth month postpartum. It is often combined with RV dysfunction, but this has rarely been described in the literature. The main aim of this study was to assess the prevalence of RV dysfunction in a PPCM population. Methods: We conducted a prospective and investigative study at the Cardiac Clinic of the Aristide Le Dantec Teaching Hospital in Dakar, Senegal, between March and June 2013. All patients hospitalized during the study period and meeting the diagnostic criteria for PPCM were included. Results: During the study period, 326 patients were hospitalized in the cardiology department; 19 were diagnosed with PPCM corresponding to a hospital prevalence of 5.8%. All patients had left ventricular dysfunction, with an average ejection fraction of 23.01%±9.73% at the Simpson biplane. Based on the tricuspid annular plane systolic excursion (TAPSE), 11 out of the 19 patients (57.9%) had RV systolic dysfunction. Ten patients (52.6%) had an Sa tricuspid wave (speed of the systolic wave to the tricuspid ring in tissue Doppler) below the standard. The average RV area shortening was 23.73%±14.16%, with extremes of 7.8% and 53.7%. Fifteen patients (78.9%) had a rate of shortening fraction of the surface area of RV below the standard. When the other parameters were taken into account, 15 patients (78.9%) had at least 3 of the following indexes altered: fractional area change (FAC), Sa tricuspid, TAPSE, and the ratio between the sum of both isovolumic times and the ejection time (TEI index). Conclusion: RV dysfunction is common in PPCM. In view of the prognostic interest on the right ventricle; its evaluation must take into account all of the measurement parameters in order to allow for better detection.

show abstract

Section: Discussionsupporting

confidence: 54%

Prevalence and characteristics of dysfunction of right ventricle in peripartum cardiomyopathy

Fatou¹,

Ndiaye²,

Sarr³

et al. 2017

RRCC

View full text Add to dashboard Cite

show abstract

“…16,17 Careful assessment of the risk factors in pregnant women could help prevent PPCM. 18 Reducing the risk for relapse of heart failure in a subject with PPCM with or without a subsequent pregnancy is promoted if there is a more rapid return to LVEF 55% after initial diagnosis, especially if that occurs by 1-year postpartum. 19 Delayed time to diagnosis is associated with lower rates of LV recovery.…”

Section: Resultsmentioning

confidence: 99%

Updated study of peripartum cardiomyopathy and preeclampsia

Kamajaya¹,

Ariyana²

2022

MOG

View full text Add to dashboard Cite

HIGHLIGHTS 1. Cardiovascular disease that occurs during pregnancy is the peripartum cardiomyopathy (PPCM).2. Literature on the association between preeclampsia (PE) and PPCM was reviewed.3. It was not certain whether PE is the independent risk factor of PPCM or an early predictor of PPCM development. ABSTRACT Objectives: This paper aims to review the literature related to peripartum cardiomyopathy (PPCM) and preeclampsia (PE) in order to know their frequency and relationship and the current knowledge on their pathophysiology and management. Materials and Methods: The articles reviewed in this study were primary clinical studies published around 2016 and 2021, retrieved using Google Scholar and PUBMED databases. After several evaluations, 14-full-text studies written in English were examined. Results: Overall prevalence of PE in PPCM cases varied, about 9.9% - 44% in the individual studies. The lactation hormone prolactin and placental-derived anti-angiogenic factor soluble Fms-like tyrosine kinase 1 (sFlt-1), which had been known to be able to cause cardiac dysfunction, were elevated in both PE and PPCM. This partly explained the pathophysiology that the incidence of concurrent PE in women diagnosed with PPCM was four times more than that in the general population. Conclusion: Epidemiologic studies showed significant overlap between PE and PPCM patients. However, there were not enough good quality data to fully draw conclusions about the relationship between PE and PPCM, whether PE as the independent risk factor of PPCM or an early predictor of PPCM development.

show abstract

“…Walaupun milrinon termasuk golongan obat kategori C, namun pada dasarnya tidak ada kontraindikasi penggunaan milrinon pada ibu hamil. 16 Pada penelitian di hewan coba, milrinon tidak memiliki efek samping terhadap aliran darah uterus dan hemodinamik janin. 17 Milrinon merupakan obat golongan inhibitor fosfodiesterase III bipiridin, yang diindikasikan untuk penopang jantung pada pasien dengan gagal jantung akut, hipertensi pulmonal atau gagal jantung kronik.…”

Section: Diskusiunclassified

Penggunaan Milrinon pada Pasien dengan Sindrom Eisenmenger yang Menjalani Operasi Seksio Sesarea

Dwiputra

Soenarto

2021

MACC

View full text Add to dashboard Cite

Sindrom Eisenmeger adalah kelainan jantung dengan karakteristik hipertensi pulmonal yang disertai pirau kanan ke kiri ataupun dua arah, akibat jangka panjang defek septum interventrikel atau patent ductus arteriosus (PDA) yang tidak diterapi. Kehamilan sulit ditoleransi pada pasien dengan sindrom Eisenmenger dimana mortalitas ibu mencapai 30-50%. Perubahan fisiologis menurunkan tahanan vaskular sistemik yang memperburuk pirau.2 Seksio Sesarea merupakan pilihan teknik persalinan pada kondisi tersebut. Kami melaporkan dua pasien dengan sindrom Eisenmenger yang berhasil menjalani seksio sesarea dengan anestesi umum. Anestesi umum dilakukan dengan teknik titrasi dan menggunakan obat dengan pengaruh minimal terhadap sistem kardiovaskular. Selama operasi pasien diberikan milrinon yang dikombinasikan dengan agen katekolamin. Pascaoperasi pasien dirawat di ICU. Selama perawatan di ICU tidak ada komplikasi signifikan yang terjadi. Pasien pertama berhasil pindah ke ruang rawat pada hari ke-3 pascaoperasi, sedangkan pasien ke-2 pindah pada hari ke-7 pascaoperasi. Tujuan manajemen anestesi pada pasien sindrom Eisenmenger adalah mempertahankan SVR, menjaga kecukupan volume intravaskular dan mencegah peningkatan lebih jauh PVR. Penggunaan milrinon yang dikombinasikan dengan agen katekolamin dapat membantu tercapainya tujuan tersebut sehingga dapat memperbaiki oksigenasi dan mempertahankan hemodinamik pasien. Walaupun kehamilan pada pasien Eisenmenger tidak dianjurkan, namun persalinan melalui seksio Sesarea masih dapat dilakukan dengan manajemen yang baik.

show abstract

Peripartum cardiomyopathy: challenges and solutions

Cited by 5 publications

References 54 publications

Prevalence and characteristics of dysfunction of right ventricle in peripartum cardiomyopathy

Prevalence and characteristics of dysfunction of right ventricle in peripartum cardiomyopathy

Updated study of peripartum cardiomyopathy and preeclampsia

Penggunaan Milrinon pada Pasien dengan Sindrom Eisenmenger yang Menjalani Operasi Seksio Sesarea

Contact Info

Product

Resources

About