Peripheral and spinal 5-HT receptors participate in the pronociceptive and antinociceptive effects of fluoxetine in rats

Cervantes-Durán, Claudia; Rocha-González, Héctor Isaac; Granados‐Soto, Vinicio

doi:10.1016/j.neuroscience.2013.08.022

Cited by 43 publications

(40 citation statements)

References 89 publications

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“…5-HT 5A, 5-HT 1A, and a-2A adrenoreceptors are all known to be involved in spinal mechanisms of antinociception. 2,7,11,69,70 Blocking 5-HT 1A receptors with WAY-100635 was the only treatment that effectively reversed N 2 -AcPLZ-mediated antinociception. This suggests that increased levels of 5-HT in response to N 2 -AcPLZ acts through the 5-HT 1A receptor in the spinal cord to mediate antinociception in male mice after formalin stimulation.…”

Section: Discussionmentioning

confidence: 98%

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Manipulation of Neurotransmitter Levels Has Differential Effects on Formalin-Evoked Nociceptive Behavior in Male and Female Mice

Mifflin

Benson

Thorburn

et al. 2016

The Journal of Pain

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Section: Discussionmentioning

confidence: 98%

“…All antagonists used have previously been shown to not alter formalin behavior compared with VEH treatment alone. 11,32,48,54,55 Male mice were pretreated with N 2 -AcPLZ or VEH (bacteriostatic water). Twenty minutes before formalin testing, mice received an intrathecal (i.t.)…”

Section: Experiments 4 and 5: Effect Of Gonadectomy On Mice Pretreatementioning

confidence: 99%

Manipulation of Neurotransmitter Levels Has Differential Effects on Formalin-Evoked Nociceptive Behavior in Male and Female Mice

Mifflin

Benson

Thorburn

et al. 2016

The Journal of Pain

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“…The spinal injection site was checked by injecting a dye (methylene blue) solution at the end of the experiment. Doses of 5-HT (1 mol/head), ketanserin (100 nmol/head), dolasetron (100 nmol/head), and fluoxetine (3 nmol/ head) were selected according to previous studies in rats (6,7,29,32). A previous study showed that injection of bicuculline at a dose of 20 nmol in the spinal cord in rats causes muscle contractions, and thereby injection of a muscle relaxant is required (4).…”

Section: Methodsmentioning

confidence: 99%

Medullary raphe nuclei activate the lumbosacral defecation center through the descending serotonergic pathway to regulate colorectal motility in rats

Nakamori

Naitou

Horii

et al. 2018

American Journal of Physiology-Gastrointestinal and Liver Physi

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Colorectal motility is regulated by two defecation centers located in the brain and spinal cord. In previous studies, we have shown that administration of serotonin (5-HT) in the lumbosacral spinal cord causes enhancement of colorectal motility. Because spinal 5-HT is derived from neurons of the medullary raphe nuclei, including the raphe magnus, raphe obscurus, and raphe pallidus, we examined whether stimulation of the medullary raphe nuclei enhances colorectal motility via the lumbosacral defecation center. Colorectal pressure was recorded with a balloon in vivo in anesthetized rats. Electrical stimulation of the medullary raphe nuclei failed to enhance colorectal motility. Because GABAergic neurons can be simultaneously activated by the raphe stimulation and released GABA masks accelerating actions of the raphe nuclei on the lumbosacral defecation center, a GABA receptor antagonist was preinjected intrathecally to manifest excitatory responses. When spinal GABA receptors were blocked by the antagonist, electrical stimulation of the medullary raphe nuclei increased colorectal contractions. This effect of the raphe nuclei was inhibited by intrathecal injection of 5-hydroxytryptamine type 2 (5-HT) and type 3 (5-HT) receptor antagonists. In addition, injection of a selective 5-HT reuptake inhibitor in the lumbosacral spinal cord augmented the raphe stimulation-induced enhancement of colorectal motility. Transection of the pelvic nerves, but not transection of the colonic nerves, prevented the effect of the raphe nuclei on colorectal motility. These results demonstrate that activation of the medullary raphe nuclei causes augmented contractions of the colorectum via 5-HT and 5-HT receptors in the lumbosacral defecation center. NEW & NOTEWORTHY We have shown that electrical stimulation of the medullary raphe nuclei causes augmented contractions of the colorectum via pelvic nerves in rats. The effect of the medullary raphe nuclei on colorectal motility is exerted through activation of 5-hydroxytryptamine type 2 and type 3 receptors in the lumbosacral defecation center. The descending serotoninergic raphespinal tract represents new potential therapeutic targets against colorectal dysmotility such as irritable bowel syndrome.

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“…5-HT and its receptors are also present in peripheral tissues where they influence several functions including intestinal motility (Foxx-Orenstein et al, 1996), immune/inflammatory response (Ahern, 2011), modulation of nociception (Cervantes-Duran et al, 2013). Seven families of 5-HT receptors have been identified to date in mammals, 5-HT 1 through 5-HT 7 , each including distinct receptor subtypes.…”

Section: Introductionmentioning

confidence: 99%

5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders

Ciranna

Catania

2014

Front. Cell. Neurosci.

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Serotonin type 7 receptors (5-HT7) are expressed in several brain areas, regulate brain development, synaptic transmission and plasticity, and therefore are involved in various brain functions such as learning and memory. A number of studies suggest that 5-HT7 receptors could be potential pharmacotherapeutic target for cognitive disorders. Several abnormalities of serotonergic system have been described in patients with autism spectrum disorder (ASD), including abnormal activity of 5-HT transporter, altered blood and brain 5-HT levels, reduced 5-HT synthesis and altered expression of 5-HT receptors in the brain. A specific role for 5-HT7 receptors in ASD has not yet been demonstrated but some evidence implicates their possible involvement. We have recently shown that 5-HT7 receptor activation rescues hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome, a monogenic cause of autism. Several other studies have shown that 5-HT7 receptors modulate behavioral flexibility, exploratory behavior, mood disorders and epilepsy, which include core and co-morbid symptoms of ASD. These findings further suggest an involvement of 5-HT7 receptors in ASD. Here, we review the physiological roles of 5-HT7 receptors and their implications in Fragile X Syndrome and other ASD.

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Peripheral and spinal 5-HT receptors participate in the pronociceptive and antinociceptive effects of fluoxetine in rats

Cited by 43 publications

References 89 publications

Manipulation of Neurotransmitter Levels Has Differential Effects on Formalin-Evoked Nociceptive Behavior in Male and Female Mice

Manipulation of Neurotransmitter Levels Has Differential Effects on Formalin-Evoked Nociceptive Behavior in Male and Female Mice

Medullary raphe nuclei activate the lumbosacral defecation center through the descending serotonergic pathway to regulate colorectal motility in rats

5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders

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