Peripheral Antinociceptive Effects of Exogenous and Immune Cell-Derived Endomorphins in Prolonged Inflammatory Pain

Łabuz, Dominika; Berger, Stephan; Mousa, Shaaban A.; Zöllner, Christian; Rittner, Heike L.; Shaqura, Mohammed; Segovia-Silvestre, Toni; Przewłocka, Barbara; Stein, Christoph; Machelska, Halina

doi:10.1523/jneurosci.4349-05.2006

Cited by 78 publications

(83 citation statements)

References 48 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, peripheral opioid mechanisms of pain control become more prevalent with the progression and severity of inflammation. The most prominent opioid peptide involved is END, but Met-enkephalin, dynorphin, and endomorphins also contribute to attenuation of nociception in this model (Stein et al, 1990a;Machelska et al, 2003;Labuz et al, 2006). Endogenous triggers of this stressinduced analgesia are locally produced CRF and sympathetic neuron-derived catecholamines (Schafer et al, 1996;Machelska et al, 2003;Binder et al, 2004).…”

Section: Intrinsic Induction Of Opioid Peptide Release From Inflammatmentioning

confidence: 92%

“…In vivo murine neutrophils and monocytes/macrophages expressed PENK mRNA in zymosan-or thioglycollate-induced experimental peritoneal inflammation (Chadzinska et al, 2001). Leu-enkephalin, dynorphin and endomorphins were demonstrated in various types of immune cells (Cabot et al, 2001;Mousa et al, 2002;Chadzinska et al, 2005;Labuz et al, 2006).…”

Section: Opioid Peptides In Peripheral Sensorymentioning

confidence: 99%

“…In peripheral tissues subpopulations of opioid peptidecontaining cells include granulocytes, monocytes/macrophages and lymphocytes (Przewłocki et al, 1992;Mousa et al, 2001Mousa et al, , 2007bRittner et al, 2001Rittner et al, , 2007aLabuz et al, 2006Labuz et al, , 2010Verma-Gandhu et al, 2006;Zöllner et al, 2008). Most notably, regulatory T cells (a population suppressing inflammatory responses) were shown to express the PENK gene (McHugh et al, 2002;Zelenika et al, 2002).…”

Section: Opioid Peptides In Peripheral Sensorymentioning

confidence: 99%

“…When applied to peripheral injured tissue, all the releasing agents mentioned in section II.B.4 can produce opioid-mediated antinociceptive effects in vivo. Depending on the agent, stage, and type of inflammation, these effects are mediated by different opioid peptides (Schä fer et al, 1994;Mousa et al, 2003;Binder et al, 2004;Brack et al, 2004c;Labuz et al, 2006Labuz et al, , 2009. Recent studies have suggested that ␣ 2 -adrenergic agonists and serine proteases can also induce antinociception via enhanced production and release of endogenous opioids in models of inflammation (Ansah and Pertovaara, 2007;Martin et al, 2009).…”

Section: Extrinsic Stimulation Of Opioid Peptidementioning

confidence: 99%

See 3 more Smart Citations

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

Stein

Machelska

2011

Pharmacological Reviews

164

191

View full text Add to dashboard Cite

Section: Intrinsic Induction Of Opioid Peptide Release From Inflammatmentioning

confidence: 92%

Section: Opioid Peptides In Peripheral Sensorymentioning

confidence: 99%

Section: Opioid Peptides In Peripheral Sensorymentioning

confidence: 99%

Section: Extrinsic Stimulation Of Opioid Peptidementioning

confidence: 99%

See 2 more Smart Citations

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

Stein

Machelska

2011

Pharmacological Reviews

164

191

View full text Add to dashboard Cite

“…PBMCs are a key link in inflammatory response [35]. There are strong immunoreactivities for β-endorphin, EM-1, and EM-2 in leukocytes of inflamed subcutaneous paw tissue at 4 days after intraplantar injection of complete Freund's adjuvant [27]. These leukocytes had morphological appearances consistent with mononuclear cells and granulocytes.…”

Section: Discussionmentioning

confidence: 99%

Puerarin alleviates burn-related procedural pain mediated by P2X3 receptors

Zhang

Gao

et al. 2011

Purinergic Signalling

View full text Add to dashboard Cite

Pain is a major problem after burns. Procedural pain evoked by burn dressing changes is common in patients, and its management is a critical part of treatment in acute burn injuries. Burn pain is very likely the most difficult form of acute pain to treat. ATP contributes to inflammation, and ATP is implicated in peripheral pain signaling via actions upon P2X 3 receptors. Puerarin is extracted from a traditional Chinese medicine and may act on P2X 3 receptor mechanisms. The Visual Analogue Scale (VAS) has been shown to be a sensitive indicator of pain intensity and treatment effects. Peripheral blood mononuclear cells (PBMCs) are involved in nociception or pain after burn injury. Burn patients were randomly divided into normal saline (NS) group (salt solution is saline) and puerarin-treated group and pain (Visual Analogue Scale scores) and inflammation (PBMCs) measured. Burn pain produces a stress response, so blood glucose, insulin, and cortisol levels in burn patients were determined. Furthermore, the expression of P2X 3 protein and mRNA in PBMCs was detected. The VAS scores in the puerarintreated group were lower than those in NS group. The blood glucose, insulin, and cortisol levels in the puerarintreated group at post-dressing changes were significantly decreased in comparison with those in NS group. The expression levels of P2X 3 protein and mRNA in PBMCs of burn patients in NS group were significantly increased in comparison with those in the puerarin-treated group. Puerarin can antagonize inflammatory factors (such as ATP) and decrease the upregulated expressions of P2X 3 protein and mRNA in PBMCs after burns to decrease VAS. Thus, puerarin had an analgesic effect on procedural pain in dressing changes of burn patients related to P2X 3 receptors.

show abstract

Antiinflammatory role of endomorphins in osteoarthritis, rheumatoid arthritis, and adjuvant‐induced polyarthritis

Straub¹,

Wolff²,

Faßold³

et al. 2008

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. Pain sensitization and the related secretion of neuropeptides from sensory nerve terminals are proinflammatory in osteoarthritis (OA), rheumatoid arthritis (RA), and adjuvant-induced polyarthritis. In contrast, endogenous opioids such as the recently discovered endomorphins (EMs) are antiinflammatory. However, the role of endogenous EMs such as EM-1 and EM-2 has never been investigated in OA and RA.Methods. We established a highly sensitive radioimmunoassay to detect EM-1 and EM-2. In patients with RA and patients with OA, immunohistochemistry for EM-1 and EM-2 was performed, and double-staining was used to identify EM-positive cells. The effects of EM-1 and EM-2 on the secretion of interleukin-6 (IL-6) and IL-8 from human synovial tissue were studied by tissue superfusion, and the therapeutic effects of EM-1 were tested in a rat model of adjuvant-induced polyarthritis.Results. EM-positive cells were located in the sublining area and vessel walls but were particularly evident in the highly inflamed lining area. Human macrophages, T cells, and fibroblasts stained positive for EMs. The synovial density of EM-positive cells was higher in patients with OA than in those with RA.

show abstract

Peripheral Antinociceptive Effects of Exogenous and Immune Cell-Derived Endomorphins in Prolonged Inflammatory Pain

Abstract: Endomorphins (EMs

Cited by 78 publications

References 48 publications

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

Puerarin alleviates burn-related procedural pain mediated by P2X3 receptors

Antiinflammatory role of endomorphins in osteoarthritis, rheumatoid arthritis, and adjuvant‐induced polyarthritis

Contact Info

Product

Resources

About