Peripheral apelin-13 administration inhibits gastrointestinal motor functions in rats: The role of cholecystokinin through CCK1 receptor-mediated pathway

Bülbül, Mehmet; Sinen, Osman; Birsen, İlknur; İzgüt‐Uysal, V. Nimet

doi:10.1016/j.npep.2016.12.001

Cited by 16 publications

(8 citation statements)

References 47 publications

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“…The main hormone that regulates exocrine pancreatic secretion is cholecystokinin (CCK) that can bind to the CCK1 receptor localized on pancreatic acinar cells and stimulate the release of digestive enzymes. CCK can also bind to the CCK1 receptor on capsaicin-sensitive C-type vagal afferent nerves and generate a signal sent to the brain stem from where it is transmitted to the pancreas (Wright et al, 2011;Campos et al, 2012;Bülbül et al, 2017). As found previously, the group of intestinal regulatory peptides that affect digestive function includes, among others, ghrelin, leptin, apelin and obestatin (Matyjek et al, 2004;Kapica et al, 2008;Antushevich et al, 2016).…”

Section: Introductionmentioning

confidence: 89%

Exogenous obestatin affects pancreatic enzyme secretion in rat through two opposite mechanisms, direct inhibition and vagally-mediated stimulation

Kapica¹,

Puzio²,

Kato³

et al. 2018

J. Anim. Feed Sci.

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Section: Introductionmentioning

confidence: 89%

Exogenous obestatin affects pancreatic enzyme secretion in rat through two opposite mechanisms, direct inhibition and vagally-mediated stimulation

Kapica¹,

Puzio²,

Kato³

et al. 2018

J. Anim. Feed Sci.

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“…Antuschevich et al () also found that apelin can affect CCK release and stimulate some gastric and pancreatic enzyme activity in adult rats. Peripherally administered apelin‐13 inhibits GI tissue motor functions through the CCK‐dependent pathway, which appears to be mediated by CCK1 receptors on vagal afferents (Bulbul et al, ). In addition, apelin also induced a release of CCK from dispersed intestinal endocrine cells (Tatemoto, ) and proximal small intestine cells (Wattez et al, ).…”

Section: Digestive Physiological Actions Of Apelin and Apjmentioning

confidence: 99%

Function and regulation of apelin/APJ system in digestive physiology and pathology

Huang

Luo

Liu

et al. 2018

Journal Cellular Physiology

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Apelin is an endogenous ligand of seven‐transmembrane G‐protein‐coupled receptor APJ. Apelin and APJ are distributed in various tissues, including the heart, lung, liver, kidney, and gastrointestinal tract and even in tumor tissues. Studies show that apelin messenger RNA is widely expressed in gastrointestinal (GI) tissues, including stomach and small intestine, which is closely correlated with GI function. Thus, the apelin/APJ system may exert a broad range of activities in the digestive system. In this paper, we review the role of the apelin/APJ system in the digestive system in physiological conditions, such as gastric acid secretion, control of appetite and food intake, cell proliferation, cholecystokinin secretion and histamine release, gut–brain axis, GI motility, and others. In pathological conditions, the apelin/APJ system plays an important role in the healing process of stress gastric injury, the clinical features and prognosis of patients with gastric cancers, the reduction of inflammatory response to enteritis and pancreatitis, the mediation of liver fibrogenesis, the promotion of liver damage, the inhibition of liver regeneration, the contribution of splanchnic neovascularization in portal hypertension, the treatment of colon cancer, and GI oxidative damage. Overall, the apelin/APJ system plays diversified functions and regulatory roles in digestive physiology and pathology. Further exploration of the relationship between the apelin/APJ system and the digestive system will help to find new and effective drugs for treating and alleviating the pain of digestive diseases.

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“…Accumulating evidence also suggests an anorexic effect of central administration of apelin in rodents (26,40), implying that apelin may be released in response to the ingestion of a meal. Interestingly, a recent report indicated that the inhibitory effect of peripherally administered apelin-13 on GE and CT was abolished following afferent denervation by capsaicin (10). It should be noted, however, that peripheral capsaicin also induces significant damage to vagal efferent fibers, rendering these results difficult to interpret (5).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it has been established that overnight fasting significantly reduced the expression of APJ receptor in nodose ganglia in mice and reduced gastroesophageal vagal mechanoreceptors responsiveness, suggesting that apelin plays a role in the regulation of food intake through vagal afferent pathways (34a). Indeed, apelin-induced anorexigenic effects were abolished by administration of the cholecystokinin receptor type-1 antagonist lorglumide, suggesting a modulatory role of apelin on second-order NTS neurons via a vagal afferent pathway (10). Accumulating evidence also suggests an anorexic effect of central administration of apelin in rodents (26,40), implying that apelin may be released in response to the ingestion of a meal.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Apelin-13 inhibits gastric motility through vagal cholinergic pathway in rats

Bülbül

Sinen

Gök

et al. 2018

American Journal of Physiology-Gastrointestinal and Liver Physi

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The expression of apelin and its receptors (APJ) in central autonomic networks suggests that apelin may regulate gastrointestinal motor functions. In rodents, central administration of apelin-13 has been shown to inhibit gastric emptying; however, the mechanisms involved remain to be determined. Using male adult Sprague-Dawley rats, the aims of the present study were 1) to determine the expression of APJ receptor in the dorsal vagal complex (DVC), 2) to assess the effects of central application of apelin-13 into the DVC on gastric tone and motility, and 3) to investigate the neuronal pathways responsible for apelin-induced alterations. APJ receptor immunoreactivity was detected in gastric-projecting and choline acetyltransferase-positive neurons of the DVC. Microinjection of apelin-13 into the DVC significantly decreased gastric tone and motility in both corpus and antrum. The apelin-induced reduction in gastric tone and motility was prevented by surgical vagotomy or fourth ventricular application of the APJ receptor antagonist, [Ala13]apelin-13 (F13A). Systemic administration of the muscarinic receptor antagonist atropine, but not the nitric oxide synthase inhibitor nitro-l-arginine methyl ester (l-NAME), abolished the apelin-induced inhibitory responses. The present results indicate a central modulatory role of apelin in the vagal neurocircuitry that controls gastric motor functions via withdrawal of the tonically active cholinergic pathway. NEW & NOTEWORTHY This is the first study investigating the effects induced by brain stem application of apelin-13 while monitoring gastric tone and motility in rats. We have found that gastric-projecting neurons of the dorsal vagal complex express apelin receptors (APJ), which mediate the inhibitory actions of apelin-13. The inhibitory effects of apelin were abolished by systemic preadministration of atropine, but not nitro-l-arginine methyl ester (l-NAME). Apelin seems to modulate gastric motility via withdrawal of the tonically active vagal cholinergic pathway.

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Peripheral apelin-13 administration inhibits gastrointestinal motor functions in rats: The role of cholecystokinin through CCK1 receptor-mediated pathway

Cited by 16 publications

References 47 publications

Exogenous obestatin affects pancreatic enzyme secretion in rat through two opposite mechanisms, direct inhibition and vagally-mediated stimulation

Exogenous obestatin affects pancreatic enzyme secretion in rat through two opposite mechanisms, direct inhibition and vagally-mediated stimulation

Function and regulation of apelin/APJ system in digestive physiology and pathology

Apelin-13 inhibits gastric motility through vagal cholinergic pathway in rats

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