Peripheral Artery Disease and Markers of Endothelial Dysfunction and Platelet Activation in People With HIV

Bundgård, Johanne; Jensen, Anne Marie; Suarez-Zdunek, Moises Alberto; Høgh, Julie; Gerstoft, Jan; Benfield, Thomas; Ostrowski, Sisse Rye; Nielsen, Susanne Dam; Knudsen, Andreas

doi:10.1097/qai.0000000000003194

JAIDS Journal of Acquired Immune Deficiency Syndromes

2023

DOI: 10.1097/qai.0000000000003194

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Peripheral Artery Disease and Markers of Endothelial Dysfunction and Platelet Activation in People With HIV

Johanne Bundgård

Anne Marie Jensen

Moises Alberto Suarez-Zdunek

et al.

Abstract: Supplemental Digital Content is Available in the Text.

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2024

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Endothelial injury and decline in lung function in persons living with HIV: a prospective Danish cohort study including 698 adults

Rønn,

Knudsen,

Arentoft

et al. 2024

Front. Med.

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ObjectivesEndothelial injury may promote declining lung function. We aimed to investigate in well-treated persons living with HIV (PLWH) whether elevated levels of thrombomodulin (TM) and syndecan-1 (SDC1) are associated with excess lung function decline and worsening dyspnea.MethodsA prospective cohort study comprising patients from the Copenhagen municipality. We included 698 PLWH with undetectable viral load. Biomarkers and demographics were measured at baseline, spirometry [forced expiratory volume in one second (FEV1) and forced vital capacity (FVC)] and dyspnea score both at baseline and 2-year follow-up.Both biomarkers were dichotomized at the 3rd quartile. Decline in lung function was estimated using a linear mixed model with patient-specific random effect. Increase in dyspnea score was estimated using a general mixed logistic regression model.ResultsWe did not find an association between elevated SDC1 or TM and an excess decline in neither FEV1: SDC1: 4.5 mL/year (95% CI: −3.9–12.9, p = 0.30), TM: 2.2 mL/year (95% CI: −6.0–10.4, p = 0.60) nor FVC: SDC1: 4.1 mL/year (95% CI: −6.0–14.2, p = 0.42), TM: 1.4 mL/year (95% CI: −8.3–11.1, p = 0.78). A subgroup analysis of never-smokers was consistent with the main analysis.Likewise, we did not find any association between elevated SDC1 and TM and increase in dyspnea score: SDC1: OR 1.43 (95% CI: 0.89–2.30, p = 0.14), TM: OR 1.05 (95% CI: 0.65–1.71, p = 0.26).ConclusionWe did not find a significant association between elevated biomarkers of endothelial injury and decline in lung function nor dyspnea.

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Endothelial injury and decline in lung function in persons living with HIV: a prospective Danish cohort study including 698 adults

Rønn,

Knudsen,

Arentoft

et al. 2024

Front. Med.

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show abstract

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Peripheral Artery Disease and Markers of Endothelial Dysfunction and Platelet Activation in People With HIV

Abstract: Supplemental Digital Content is Available in the Text.

Cited by 1 publication

References 45 publications

Endothelial injury and decline in lung function in persons living with HIV: a prospective Danish cohort study including 698 adults

Endothelial injury and decline in lung function in persons living with HIV: a prospective Danish cohort study including 698 adults

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