Peripheral biomarkers of oxidative stress in dogs with acute pancreatitis

Tusa, Nicole V.; Abuelo, Ãngel; Levy, Nyssa A; Gandy, J.C.; Langlois, Daniel K.; Cridge, Harry

doi:10.1111/jvim.16535

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…Therefore, it may be useful as an indicator in cases in which rapid therapeutic intervention must be assessed. Recent human and veterinary medicine studies have revealed that evaluating both positive APPs and negative APPs in patients may be better for confirming the degree of inflammation and predicting survival (11,27,40,41). For instance, during inflammation, the plasma CRP concentration increases, while the PAB concentration decreases.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of plasma prealbumin as a novel inflammatory biomarker in dogs: a pilot study

Park

Kim

et al. 2023

Front. Vet. Sci.

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IntroductionPrealbumin (PAB) is a plasma protein synthesized in the hepatic parenchymal cells. PAB has a short half-life (~2 days), and its concentration is affected by changes in transcapillary escape. Measurement of PAB is widely used in hospitalized patients in human medicine due to its decreasing concentration in states of inflammation and malnutrition. However, only a few studies are available in dogs. The aim of this study is to determine whether the plasma PAB concentration decreases in dogs with inflammation and to evaluate the relationship between the plasma PAB concentration and inflammation-related parameters in dogs.MethodsA total of 94 dogs were divided into healthy (n = 33) and diseased (n = 61) groups. These were further divided into group A (n = 24) and group B (n = 37) according to plasma C-reactive protein (CRP) levels. Group A included dogs with a plasma CRP < 10 mg/L, and group B consisted of dogs with a plasma CRP ≥ 10 mg/L. Patient signalment, history, physical examination findings, hematologic and biochemical parameters, various inflammatory markers, and plasma PAB levels were investigated and compared between groups.ResultsThe plasma PAB concentration was found to be lower in group B than in the other groups (p < 0.001), but no statistical difference was found when comparing the control group and group A (p > 0.05). A plasma PAB < 6.3 mg/dL predicted an increased CRP level (10 mg/L or greater) with a sensitivity of 89.5% and a specificity of 86.5%. Receiver operating characteristic curve analysis revealed that the area under the curve for PAB was higher than that for the white blood cell count, neutrophil count, albumin level, lactate level, neutrophil-to-lymphocyte ratio, and neutrophil percentage-to-albumin ratio. In addition, the PAB concentration was significantly negatively correlated with the CRP concentration (r = −0.670, p < 0.001).ConclusionIn conclusion, this is the first study to demonstrate the clinical usefulness of the plasma PAB concentration as an inflammatory marker in dogs. These findings suggest that measuring the plasma PAB concentration along with the CRP concentration may be more useful for evaluating inflammation than measuring CRP alone in canine patients.

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Section: Discussionmentioning

confidence: 99%

Evaluation of plasma prealbumin as a novel inflammatory biomarker in dogs: a pilot study

Park

Kim

et al. 2023

Front. Vet. Sci.

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Peripheral biomarkers of oxidative stress in dogs with acute pancreatitis

Tusa

Abuelo

Levy

et al. 2022

Veterinary Internal Medicne

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Background Oxidative stress is considered a pathomechanism of acute pancreatitis (AP), but no studies have extensively characterized oxidant status in dogs with naturally‐occurring AP. Hypothesis or Objectives Evaluate measures of oxidant status in dogs with AP and explore whether these measures correlate with AP severity. Animals Fifteen dogs with AP and 9 control dogs. Methods Prospective, controlled observational study. Plasma reactive metabolite (RM) concentrations, antioxidant potential (AOP), and urinary F2 isoprostane concentrations were measured in AP dogs and healthy controls. Severity of AP was assessed by length of hospitalization and 3 disease severity indices: canine acute pancreatitis severity (CAPS), modified canine activity index (M‐CAI), and the acute patient physiologic and laboratory evaluation score (APPLEfull). Results Reactive metabolite (RM) concentrations (median, 65 relative fluorescent units [RFU]/μL; range, 20‐331 RFU/μL) and RM:AOP (median, 7; range, 4‐109) were higher in AP dogs than healthy controls (median RM, 25 RFU/μL; range, 16‐41 RFU/μL; median RM:AOP, 4; range, 2‐7; P < .001 for both comparisons). Reactive metabolite (rS = 0.603, P = .08) and RM:AOP (rS = 0.491, P = .06) were not correlated with the duration of hospitalization or disease severity indices evaluated. However, disease severity indices did not predict mortality in our study. Normalized urine 2,3‐dinor‐8‐iso‐prostaglandin F2α concentrations were correlated with C‐reactive protein (CRP; rS = 0.491, P = .03), canine specific pancreatic lipase (Spec cPL; rS = 0.746, P = .002), and CAPS (rS = 0.603, P = .02). Conclusions and Clinical Importance Oxidant status is altered in dogs with naturally occurring AP, but the clinical relevance of this finding is unknown.

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Oxidative Stress in Canine Diseases: A Comprehensive Review

Blanca,

María Luisa,

Guadalupe

et al. 2024

Antioxidants

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Oxidative stress (OS), defined as a disruption in redox balance favoring oxidants, has emerged as a major contributor to numerous diseases in human and veterinary medicine. While several reviews have explored the implication of OS in human pathology, an exhaustive review of the canine species is lacking. This comprehensive review aims to summarize the existing literature on the role of OS in canine diseases, highlighting its potentially detrimental effect on various organs and systems. Some inconsistencies among studies exist, likely due to varying biomarkers and sample types. However, there is substantial evidence supporting the involvement of OS in the development or progression of numerous canine disorders, such as cardiovascular, oncologic, endocrine, gastrointestinal, hematologic, renal, neurologic, infectious, and parasitic diseases, among others. Additionally, this review discusses the efficacy of antioxidant and pro-oxidant therapeutic agents for these conditions. Dietary interventions to counteract OS in dogs have gained significant attention in recent years, although further research on the topic is needed. This review aims to serve as a foundational resource for future investigations in this promising field.

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Peripheral biomarkers of oxidative stress in dogs with acute pancreatitis

Cited by 3 publications

References 52 publications

Evaluation of plasma prealbumin as a novel inflammatory biomarker in dogs: a pilot study

Evaluation of plasma prealbumin as a novel inflammatory biomarker in dogs: a pilot study

Peripheral biomarkers of oxidative stress in dogs with acute pancreatitis

Oxidative Stress in Canine Diseases: A Comprehensive Review

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