Peripheral blood and urine metabolites and biological functions in post-stroke depression

Liu, Haiyan; Pu, Juncai; Zhou, Qinxiang; Yang, Lining; Bai, Dingqun

doi:10.1007/s11011-022-00984-9

Cited by 9 publications

(4 citation statements)

References 59 publications

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“…Previous studies have indicated that phenylalanine, tyrosine, and tryptophan biosynthesis is significantly affected in acute ischemic stroke [ 48 ]. Accumulating evidence links both of these phenylalanine pathways to alterations in post-stroke depression [ 49 , 50 ]. Phenylalanine exhibits multiple metabolic pathways within the body, including its incorporation into proteins, conversion into phenylpyruvic acid, and conversion into tyrosine.…”

Section: Discussionmentioning

confidence: 99%

“…The upregulation of VMA and HVA in urine after stroke observed in this study may indicate the increased activation of the central nervous system leading to the increased breakdown of catecholamines and these metabolites have previously been identified as prognostic biomarkers for stroke [ 24 ]. The metabolite tyrosine is frequently found to be significantly altered in stroke [ 25 , 56 ] and post-stroke depression [ 49 , 50 , 59 ]. While Ormstad et al [ 56 ] argue that tyrosine levels decrease after stroke, other findings suggest that the concentration of tyrosine is increased in the acute phase [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

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Unraveling Metabolic Changes following Stroke: Insights from a Urinary Metabolomics Analysis

Petersson,

Bykowski,

Ekstrand

et al. 2024

Metabolites

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The neuropathological sequelae of stroke and subsequent recovery are incompletely understood. Here, we investigated the metabolic dynamics following stroke to advance the understanding of the pathophysiological mechanisms orchestrating stroke recovery. Using a nuclear magnetic resonance (NMR)-driven metabolomic profiling approach for urine samples obtained from a clinical group, the objective of this research was to (1) identify novel biomarkers indicative of severity and recovery following stroke, and (2) uncover the biochemical pathways underlying repair and functional recovery after stroke. Urine samples and clinical stroke assessments were collected during the acute (2–11 days) and chronic phases (6 months) of stroke. Using a 700 MHz 1H NMR spectrometer, metabolomic profiles were acquired followed by a combination of univariate and multivariate statistical analyses, along with biological pathway analysis and clinical correlations. The results revealed changes in phenylalanine, tyrosine, tryptophan, purine, and glycerophospholipid biosynthesis and metabolism during stroke recovery. Pseudouridine was associated with a change in post-stroke motor recovery. Thus, NMR-based metabolomics is able to provide novel insights into post-stroke cellular functions and establish a foundational framework for future investigations to develop targeted therapeutic interventions, advance stroke diagnosis and management, and enhance overall quality of life for individuals with stroke.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Unraveling Metabolic Changes following Stroke: Insights from a Urinary Metabolomics Analysis

Petersson,

Bykowski,

Ekstrand

et al. 2024

Metabolites

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show abstract

“…This study proves that free fatty acids are reduced due to depression and stress. Palmitate, a 16-carbon saturated fatty acid, is reduced in the brain after 13-RA administration due to stress formation and depression [82]. The linoleate, oleate, and stearate were reduced; some studies reported that this reduction is due to changes in the phospholipid formation [83].…”

Section: Discussionmentioning

confidence: 99%

13-cis-Retinoic Acid Affects Brain Perfusion and Function: In Vivo Study

Al-Saeedi

Rajendran

2023

Mol Imaging

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Purpose. Study the effects of 13-cis-retinoic acid (13-RA), a synthetic analogue of a vitamin A used for the treatment of severe acne, on the blood flow in the rat brain using technetium-99m hexamethyl propylene amine oxime (99mTc-HMPAO) imaging. Methods. A total of 30 adult male Wistar rats were divided into the control (C), low-dose (L), and high-dose (H) groups. The L and H rats were exposed subcutaneously to 0.3 and 0.5 mg, respectively, of 13-RA per kg of body weight for seven days. Brain blood flow imaging was performed using a gamma camera. Then, a region of interest (ROI) around the brain (target, T), a whole-body region (WB), and a background region (BG) was selected and delimited. The net 99mTc-HMPAO brain counts were calculated as the net target counts, NTC = T − BG / WB − BG in all groups. At the end of the 99mTc-HMPAO brain blood flow imaging, the brain, heart, kidney, lung, and liver were rapidly removed, and their uptake was determined. Brain histopathological analysis was performed using hematoxylin and eosin stains. In addition, the plasma fatty acids were studied using gas chromatography/mass spectrometry. Results. There were highly significant differences between L and H in comparison to C and across the groups. The 99mTc-HMPAO radioactivity in the brain showed increased uptake in a dose-dependent manner. There were also significant changes in the brain tissues and decreased free fatty acids among the groups compared to C. Conclusion. 13-RA increases 99mTcHMPAO brain perfusion, uptake, and function and reduces fatty acids.

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“…Liu et al identified 47 metabolites that were significantly different between Post-Stroke Depression (PSD) patients and non-PSD patients. Five of these metabolites, such as L-glutamic acid, pyroglutamic acid, palmitic acid, L-phenylalanine, and L-tyrosine, were present in both plasma and urine, with the most significant metabolic pathway change observed in phenylalanine metabolism [ 62 ].…”

Section: Metabolomics Research In Ismentioning

confidence: 99%

Metabolomic discoveries for early diagnosis and traditional Chinese medicine efficacy in ischemic stroke

Wei,

Chen,

Deng

et al. 2024

Biomark Res

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Ischemic stroke (IS), a devastating cerebrovascular accident, presents with high mortality and morbidity. Following IS onset, a cascade of pathological changes, including excitotoxicity, inflammatory damage, and blood-brain barrier disruption, significantly impacts prognosis. However, current clinical practices struggle with early diagnosis and identifying these alterations. Metabolomics, a powerful tool in systems biology, offers a promising avenue for uncovering early diagnostic biomarkers for IS. By analyzing dynamic metabolic profiles, metabolomics can not only aid in identifying early IS biomarkers but also evaluate Traditional Chinese Medicine (TCM) efficacy and explore its mechanisms of action in IS treatment. Animal studies demonstrate that TCM interventions modulate specific metabolite levels, potentially reflecting their therapeutic effects. Identifying relevant metabolites in cerebral ischemia patients holds immense potential for early diagnosis and improved outcomes. This review focuses on recent metabolomic discoveries of potential early diagnostic biomarkers for IS. We explore variations in metabolites observed across different ages, genders, disease severity, and stages. Additionally, the review examines how specific TCM extracts influence IS development through metabolic changes, potentially revealing their mechanisms of action. Finally, we emphasize the importance of integrating metabolomics with other omics approaches for a comprehensive understanding of IS pathophysiology and TCM efficacy, paving the way for precision medicine in IS management.

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Peripheral blood and urine metabolites and biological functions in post-stroke depression

Cited by 9 publications

References 59 publications

Unraveling Metabolic Changes following Stroke: Insights from a Urinary Metabolomics Analysis

Unraveling Metabolic Changes following Stroke: Insights from a Urinary Metabolomics Analysis

13-cis-Retinoic Acid Affects Brain Perfusion and Function: In Vivo Study

Metabolomic discoveries for early diagnosis and traditional Chinese medicine efficacy in ischemic stroke

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