Peripheral blood effects in benzene-exposed workers

Current understandings and perspectives on non-cancer health effects of benzene: A global concern

“…Both in experimental and epidemiologic studies, it has been reported that chronic exposure to benzene is associated with decrease in hemoglobin (Hb), platelets count, and white blood cells (WBCs) count (Travis et al, 1994, Hsieh et al, 1990. Neutrophils and mean platelet volume (MPV) in the blood have been reported as the most affected parameters by benzene exposure in workers exposed to benzene in a factory in China, where the recorded weekly average benzene concentration was 7.4 mg/m 3 (Robert Schnatter et al, 2010). Bogadi-Sare et al (1995) have reported a significant decrease in Hb and mean corpuscular hemoglobin concentration (MCH) in workers exposed via inhalation in a shoe making factory to vapors of benzene in the range of 6.0 to 47.2 mg/m 3 .…”

Electronic noses for monitoring benzene occupational exposure in biological samples of Egyptian workers

“…According to the American Conference of Governmental Industrial Hygienists (ACGIH), the maximum assigned threshold limit value of benzene, as a time-weighed average concentration, in a normal 8-hour workday and a 40-hour workweek is 30 mg/m 3 . Acute exposure to benzene can cause dizziness, euphoria, giddiness, headache, nausea, staggering gait, weakness, drowsiness, respiratory and gastrointestinal irritation, pulmonary edema and pneumonia, convulsions and paralysis [2,4]. Benzene can also cause irritation to the skin, eyes and mucous membranes.…”

“…Moreover, chronic exposure to benzene can cause fatigue, nervousness, irritability, blurred vision, and labored breathing. Repeated skin contact can cause redness, blistering, and scaly dermatitis [2,4,5]. Recent studies showed significant hematological disorders, chromosomal aberrations as well as relatively high concentration of phenol in 24-hour urine samples due to exposure to benzene in chemical industry workers [4][5][6][7].…”

“…Repeated skin contact can cause redness, blistering, and scaly dermatitis [2,4,5]. Recent studies showed significant hematological disorders, chromosomal aberrations as well as relatively high concentration of phenol in 24-hour urine samples due to exposure to benzene in chemical industry workers [4][5][6][7]. Furthermore, blood disorders may lead to anemia and other diseases causing a significant reduction in working capacity and activity of workers, loss of working hours, and the increase in the costs of medical care of the affected workers [4].…”

Avaliação citogenética e molecular de trabalhadores intoxicados pelo benzeno

“…Aparentemente não existem muitos estudos que associam o volume plaquetário médio à exposição ao benzeno, apesar de os efeitos tóxicos do benzeno no sistema hematopoiético ser descritos por mais de um século (Lan et al, 2006). Os índices observados para VPM parecem não ser um valor recorrente em outros relatos de trabalhadores expostos ao benzeno (Ruiz et al, 1993;Ward et al, 1996) embora tenha sido também observado na literatura (Pesatori et al, 2009;Schnatter et al, 2010), Esses achados devem ser analisados com cautela pois, no presente estudo os trabalhadores revelaram valores de VPM dentro do limite normal de referência para a população masculina adulta enquanto cinco indivíduos controles apresentaram índices de VPM alterados (acima dos valores de referência).…”