Peripheral Blood Flow Regulation in Human Obesity and Metabolic Syndrome

Limberg, Jacqueline K.; Morgan, Barbara J.; Schrage, William G.

doi:10.1249/jes.0000000000000083

Cited by 20 publications

(12 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Blood flow regulation and oxygen saturation are both known to deviate with respect to obesity and BMI [ 71 ]. Individuals with obesity experience increased cutaneous blood flow to meet the oxygenation needs of tissue.…”

Section: Individual Variations In the Human Populationmentioning

confidence: 99%

Sources of Inaccuracy in Photoplethysmography for Continuous Cardiovascular Monitoring

et al. 2021

View full text Add to dashboard Cite

Photoplethysmography (PPG) is a low-cost, noninvasive optical technique that uses change in light transmission with changes in blood volume within tissue to provide information for cardiovascular health and fitness. As remote health and wearable medical devices become more prevalent, PPG devices are being developed as part of wearable systems to monitor parameters such as heart rate (HR) that do not require complex analysis of the PPG waveform. However, complex analyses of the PPG waveform yield valuable clinical information, such as: blood pressure, respiratory information, sympathetic nervous system activity, and heart rate variability. Systems aiming to derive such complex parameters do not always account for realistic sources of noise, as testing is performed within controlled parameter spaces. A wearable monitoring tool to be used beyond fitness and heart rate must account for noise sources originating from individual patient variations (e.g., skin tone, obesity, age, and gender), physiology (e.g., respiration, venous pulsation, body site of measurement, and body temperature), and external perturbations of the device itself (e.g., motion artifact, ambient light, and applied pressure to the skin). Here, we present a comprehensive review of the literature that aims to summarize these noise sources for future PPG device development for use in health monitoring.

show abstract

Section: Individual Variations In the Human Populationmentioning

confidence: 99%

Sources of Inaccuracy in Photoplethysmography for Continuous Cardiovascular Monitoring

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Skeletal muscle oxidative metabolism in vivo may be lowered by hypoxia because of reduced perfusion (vascularization) in obesity, which may precede loss in muscle mitochondrial density and promote glycolytic energy utilization (90). Therefore, changes in control of skeletal muscle circulation and vascular dysfunction that occur with obesity may be implicated in impairment of skeletal muscle energy metabolism (91).…”

Section: Metabolic Alterations In Skeletal Muscle Associated With Obesitymentioning

confidence: 99%

Skeletal muscle energy metabolism in obesity

Mengeste

Rustan

Lund

2021

Obesity

View full text Add to dashboard Cite

Comparing energy metabolism in human skeletal muscle and primary skeletal muscle cells in obesity, while focusing on glucose and fatty acid metabolism, shows many common changes. Insulin‐mediated glucose uptake in skeletal muscle and primary myotubes is decreased by obesity, whereas differences in basal glucose metabolism are inconsistent among studies. With respect to fatty acid metabolism, there is an increased uptake and storage of fatty acids and a reduced complete lipolysis, suggesting alterations in lipid turnover. In addition, fatty acid oxidation is decreased, probably at the level of complete oxidation, as normalβ‐oxidation may be enhanced in obesity, which indicates mitochondrial dysfunction. Metabolic changes in skeletal muscle with obesity promote metabolic inflexibility, ectopic lipid accumulation, and formation of toxic lipid intermediates. Skeletal muscle also acts as an endocrine organ, secreting myokines that participate in interorgan cross talk. This review highlights interventions and some possible targets for treatment through action on skeletal muscle energy metabolism. Effects of exercise in vivo on obesity have been compared with simulation of endurance exercise in vitro on myotubes (electrical pulse stimulation). Possible pharmaceutical targets, including signaling pathways and drug candidates that could modify lipid storage and turnover or increase mitochondrial function or cellular energy expenditure through adaptive thermogenic mechanisms, are discussed.

show abstract

“…In people with MS, hemodynamic response to exercise is altered, with signs of impaired left ventricular systolic and diastolic function and reductions in maximal stroke volume (SV), cardiac output (CO), and heart rate (HR; Dipla et al, 2010;Roberto and Crisafulli, 2017;Ladeiras-Lopes et al, 2018;Roberto et al, 2019). Peripheral vascular responsiveness defects and exaggerated vasoconstriction due to sympathetic overactivation were observed in response to effort (Fournier et al, 2014;Milia et al, 2015b;Limberg et al, 2016). Metabolic syndrome has also been associated with cognitive dysfunction and poor performance in processing speed, visuospatial ability, semantic fluency, and executive function (Yaffe et al, 2004;Segura et al, 2009;van den Berg et al, 2009;Yates et al, 2012;Guicciardi et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Effect of Combined Mental Task and Metaboreflex Activation on Hemodynamics and Cerebral Oxygenation in Patients With Metabolic Syndrome

et al. 2020

View full text Add to dashboard Cite

The hemodynamic response to muscle metaboreflex has been reported to be significantly altered by metabolic syndrome (MS), with exaggerated systemic vascular resistance (SVR) increments and reduced cardiac output (CO) in comparison to healthy controls (CTLs). Moreover, patients with metabolic disorders, such as type 2 diabetes, have proven to have impaired cerebral blood flow in response to exercise. Thus, we hypothesized that contemporary mental task (MT) and metaboreflex would result in reduced cerebral oxygenation (COX) in these patients.Methods: Thirteen MS patients (five women) and 14 normal age-matched CTLs (six women) were enrolled in this study. All the participants underwent five different tests, each lasting 12 min: post-exercise muscle ischemia (PEMI) to activate the metaboreflex, control exercise recovery (CER), PEMI + MT, CER + MT, and MT alone. Cerebral oxygenation was evaluated using near-infrared spectroscopy with sensors applied to the forehead. Hemodynamics were measured using impedance cardiography. Results:The main results show that MS patients had higher SVR and lower CO levels compared to the CTL group during metaboreflex activation. Stroke volume and ventricular filling and emptying rates were also significantly reduced. Moreover, when MT was added to PEMI, COX was significantly increased in the CTL group with respect to the baseline (103.46 ± 3.14%), whereas this capacity was reduced in MS patients (102.37 ± 2.46%). Conclusion:It was concluded that (1) patients with MS showed hemodynamic dysregulation during the metaboreflex, with exaggerated vasoconstriction and that (2) as compared to CTL, MS patients had reduced capacity to enhance COX when an MT superimposed the metaboreflex.

show abstract

Peripheral Blood Flow Regulation in Human Obesity and Metabolic Syndrome

Cited by 20 publications

References 41 publications

Sources of Inaccuracy in Photoplethysmography for Continuous Cardiovascular Monitoring

Sources of Inaccuracy in Photoplethysmography for Continuous Cardiovascular Monitoring

Skeletal muscle energy metabolism in obesity

Effect of Combined Mental Task and Metaboreflex Activation on Hemodynamics and Cerebral Oxygenation in Patients With Metabolic Syndrome

Contact Info

Product

Resources

About