Peripheral blood galectin-1-expressing T and natural killer cells in normal pregnancy and preeclampsia

Molvarec, Attila; Blois, Sandra M.; Stenczer, Balázs; Toldi, Gergely; Tirado‐González, Irene; Ito, Mika; Saito, Tomoko; Yoneda, Satoshi; Vásárhelyi, Barna; Rigó, János; Saito, Shigeru

doi:10.1016/j.clim.2010.12.018

Cited by 45 publications

(37 citation statements)

References 42 publications

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“…embryo implantation, placentation, maternal-fetal immune tolerance, danger signaling) has been suggested by in vivo and in vitro studies [11,15–17,19,20,22,24–26,28–31,35,37,38]. Furthermore, their dysregulated expression has been observed in the ‘great obstetrical syndromes’ (Glossary) [11,26,27,29–33,35,37,39–50]. Recent evidence suggests that the evolution of these galectins (Box 1) is tightly linked to the evolution of the placenta in eutherian mammals including primates [6,8,9,15,16,51].…”

Section: Galectins As Regulators Of Multiple Biological Processesmentioning

confidence: 99%

“…Galectins expressed by maternal immune cells infiltrating the uterus may also play a key role in mammalian pregnancies [22,28,250,69,74]. Galectin-1 is selectively upregulated in a subset of natural killer cells in the uterus (uNK cells) compared to circulating NK cells [22,28].…”

Section: The Role Of Galectins Expressed In Maternal Cells At the Matmentioning

confidence: 99%

“…Indeed, the pool of maternal Treg cells normally expands during pregnancy, and they ‘suppress an aggressive maternal allogeneic response directed against the fetus’ [76]. Not surprisingly, the proportion of galectin-1 expressing peripheral blood NK cells and Treg cells is decreased in pre-eclampsia [50], a syndrome in which exaggerated maternal systemic immune activation leads to serious maternal and/or fetal complications [77]. …”

Section: The Role Of Galectins Expressed In Maternal Cells At the Matmentioning

confidence: 99%

See 2 more Smart Citations

Galectins: guardians of eutherian pregnancy at the maternal–fetal interface

Than

Romero

Kim

et al. 2012

Trends in Endocrinology & Metabolism

110

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Galectins are multifunctional regulators of fundamental cellular processes. They are also involved in innate and adaptive immune responses, and play a functional role in immune-endocrine crosstalk. Some galectins have attracted attention in the reproductive sciences because they are highly expressed at the maternal-fetal interface, their functional significance in eutherian pregnancies has been documented, and their dysregulated expression is observed in the ‘great obstetrical syndromes’. The evolution of these galectins has been linked to the emergence of eutherian mammals. Based on published evidence, galectins expressed at the maternal-fetal interface may serve as important proteins involved in maternal-fetal interactions, and the study of these galectins may facilitate the prediction, presentation, diagnosis, and treatment of pregnancy complications.

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Section: Galectins As Regulators Of Multiple Biological Processesmentioning

confidence: 99%

Section: The Role Of Galectins Expressed In Maternal Cells At the Matmentioning

confidence: 99%

Section: The Role Of Galectins Expressed In Maternal Cells At the Matmentioning

confidence: 99%

See 1 more Smart Citation

Galectins: guardians of eutherian pregnancy at the maternal–fetal interface

Than

Romero

Kim

et al. 2012

Trends in Endocrinology & Metabolism

110

View full text Add to dashboard Cite

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“…[1][2][3][4][5] Trophoblast cells have a central role in the control of maternal immune homeostasis through modulating uterine NK cell activity, decidual macrophage polarization to an alternative profile, tolerogenic dendritic cell (DC) differentiation and induction of regulatory T cells (Tregs). [6][7][8] Following the inflammatory period characteristic of implantation, an anti-inflammatory and immune tolerant microenvironment is induced to sustain immune homeostasis and successful pregnancy. Many redundant mechanisms trigger immune tolerance through key master immune regulators of different nature, such as cytokines, hormones, lectins and immune polypeptides, all of them displaying pivotal immunotolerance mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation

Ramhorst

Grasso

Paparini

et al. 2016

Cell Adhesion & Migration

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Chemokine network is central to the innate and adaptive immunity and entails a variety of proteins and membrane receptors that control physiological processes such as wound healing, angiogenesis, embryo growth and development. During early pregnancy, the chemokine network coordinates not only the recruitment of different leukocyte populations to generate the maternalplacental interface, but also constitutes an additional checkpoint for tissue homeostasis maintenance. The normal switch from a pro-inflammatory to an anti-inflammatory predominant microenvironment characteristic of the post-implantation stage requires redundant immune tolerance circuits triggered by key master regulators. In this review we will focus on the recruitment and conditioning of maternal immune cells to the uterus at the early implantation period with special interest on high plasticity macrophages and dendritic cells and their ability to induce regulatory T cells. We will also point to putative immunomodulatory polypeptides involved in immune homeostasis maintenance at the maternal-placental interface.

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“…Preeclampsia occurs in approximately 4% of all pregnancies and is one of the major causes of morbidity and mortality during early pregnancy. 111 Lower expression of vascular endothelial growth factor-C 112 and a lower percentage of Gal-1-expressing NK cells 113 in women are possibly related to preeclampsia. Preeclampsia patients carry abnormal natural cytotoxic receptors on peripheral blood CD56…”

Section: Decidual Nk Cells In Uterine Diseasesmentioning

confidence: 99%

NK cells in immunotolerant organs

Sun

Tian

et al. 2013

Cell Mol Immunol

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Organs such as the liver, uterus and lung possess hallmark immunotolerant features, making these organs important for sustaining self-homeostasis. These organs contain a relatively large amount of negative regulatory immune cells, which are believed to take part in the regulation of immune responses. Because natural killer cells constitute a large proportion of all lymphocytes in these organs, increasing attention has been given to the roles that these cells play in maintaining immunotolerance. Here, we review the distribution, differentiation, phenotypic features and functional features of natural killer cells in these immunotolerant organs, in addition to the influence of local microenvironments on these cells and how these factors contribute to organ-specific diseases.

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Peripheral blood galectin-1-expressing T and natural killer cells in normal pregnancy and preeclampsia

Cited by 45 publications

References 42 publications

Galectins: guardians of eutherian pregnancy at the maternal–fetal interface

Galectins: guardians of eutherian pregnancy at the maternal–fetal interface

Decoding the chemokine network that links leukocytes with decidual cells and the trophoblast during early implantation

NK cells in immunotolerant organs

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