Peripheral blood T lymphocyte subpopulations in patients with tuberculosis and the effect of chemotherapy

Singhal, Manmohan; Banavalikar, J.N.; Sharma, Sadhna; Saha, Kunal

doi:10.1016/0041-3879(89)90047-0

Cited by 51 publications

(30 citation statements)

References 6 publications

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“…The results showed that patients with pulmonary tuberculosis had lower CD4 counts than control group. CD4 lymphocytopenia had been previously shown in both smear positive [3,[9][10][11] and smear negative [9] pulmonary tuberculosis. Another study revealed increased CD4+ T lymphocytes in BAL fluid of patients with less advanced non-cavitary pulmonary tuberculosis and significant enhancement in percentage of CD8+ cells in severe cavitary forms [7].…”

Section: Discussionmentioning

confidence: 99%

“…The results of other researches were somehow conflicting. Some studies showed normal CD8 values in patients [11,13], some increased [9] and some decreased values [3]. Recent studies suggest that CD8 T-cells have distinctive role in immunity against Mycobacterium tuberculosis, for example they preferentially use granule exocytosis pathway and recognize heavily infected cells [5], ingest macrophages that have engulfed mycobacteria [7], secrete cytokines and lyse infected cells [6].…”

Section: Discussionmentioning

confidence: 99%

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CD4+ cell counts in patients with different clinical manifestations of tuberculosis

Davoudi¹,

Rasoolinegad²,

Masoud³

et al. 2008

Braz J Infect Dis

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Tuberculosis is the prototype of infections that require a cellular immune response for their control. It has been shown that CD4+ T-lymphocytes are most important in the protective response against Mycobacterium tuberculosis. CD8+ T-lymphocytes are also important for effective T-cell immune response. This study compares CD4+ and CD8+ baseline values in patients with different manifestations of tuberculosis. CD4+ and CD8+ in three groups of patients with tuberculosis (pulmonary, lymphadenitis, meningitis/milliary involvement) and a group of healthy volunteers were enumerated using flowcytometry. Twenty-six patients with pulmonary tuberculosis, 10 with adenitis, 16 with meningitis or milliary tuberculosis and 16 healthy volunteers entered the study. Mean CD4 in meningitis/ milliary group was significantly lower than all other groups (p<0.05). Mean CD4 counts of patients with pulmonary tuberculosis was also significantly lower than control group (p=0.01). Mean CD8 in meningitis/milliary group was significantly lower than control group (p=0.02). No relation was found between results of TSTs and CD4 values in three groups. CD4 depletion is an expectable phenomenon in patients with tuberculosis. This study shows that patients with more severe form of disease had the lowest number of both CD4 and CD8 cells which can be a sign of suppressed cellular immunity in these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

CD4+ cell counts in patients with different clinical manifestations of tuberculosis

Davoudi¹,

Rasoolinegad²,

Masoud³

et al. 2008

Braz J Infect Dis

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“…Previous studies showed that chemotherapy leads to a rise in antibody levels to several antigens [2]. In T cell anergic patients with severe disease, chemotherapy has restored tuberculin skin reactions [3], blood T-cell counts [4] and in vitro proliferation [1,5,6]. Moreover, antigen-stimulated IL-10 secretion declined following chemotherapy in most patients, while the IFN-g production had an upward trend that varied between different antigenic peptides [7].…”

Section: Introductionmentioning

confidence: 98%

Change of Th0 to Th1 Cell‐Cytokine Profile Following Tuberculosis Chemotherapy

et al. 2000

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T cells mediate protection against tuberculosis, but little is known about their role during chemotherapy of patients with active disease. Here we examined the cytokine profile of CD4 T cells before and after four months of chemotherapy in six initial skin test anergic cases. Purified protein derivative (PPD) and 16‐kDa antigen‐reactive CD4 T‐cell clones prior to therapy resided mostly in disease‐associated body fluids and were of the Th0 (interferon (IFN)‐γ + interleukin (IL)‐4) secreting profile. In contrast, the majority of postchemotherapy CD4 T‐cell clones originated from blood and were of the IFN‐γ secreting Th1 type. However, the recognition of several peptides derived from the 16‐kDa antigen was not significantly different between the Th1 and Th0 clones. We conclude that chemotherapy shifts CD4 T cells from the affected body fluids to the blood circulation, accompanied by a change from Th0 to Th1 cytokine profile.

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“…21 HIV infected smear positive patients tend to excrete significantly fewer organisms per ml of sputum than HIV-negative patients which can lead to AFB being missed if the appropriate number of sputum samples as well as high power fields is not examined by microscopy. 22 The sputum negativity tends to increase as the HIV disease and immune suppression progresses. Severe immune suppression is defined as CD4 cells <200/microL.…”

mentioning

confidence: 99%

HIV/AIDS-tuberculosis (pulmonary and extra pulmonary) co-infection: CD4 correlation

et al. 2016

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Peripheral blood T lymphocyte subpopulations in patients with tuberculosis and the effect of chemotherapy

Cited by 51 publications

References 6 publications

CD4+ cell counts in patients with different clinical manifestations of tuberculosis

CD4+ cell counts in patients with different clinical manifestations of tuberculosis

Change of Th0 to Th1 Cell‐Cytokine Profile Following Tuberculosis Chemotherapy

HIV/AIDS-tuberculosis (pulmonary and extra pulmonary) co-infection: CD4 correlation

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