Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies

Köhler, Cristiano A.; Freitas, Thiago Holanda; Maes, Michaël; Andrade, Nayanna Quezado de; Liu, C. S.; Fernandes, Brisa S.; Stubbs, Brendon; Solmi, Marco; Veronese, Nicola; Herrmann, Nathan; Raison, Charles L.; Miller, Brian J.; Lanctôt, Krista L.; Carvalho, André F.

doi:10.1111/acps.12698

Cited by 1,103 publications

(830 citation statements)

References 74 publications

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“…Another meta‐analysis of inflammatory biomarkers in patients with MDD undergoing antidepressant treatment reported no decrease in the elevated baseline TNFα level. In that report, however, there was a decrease in the TNFα level in responders compared with nonresponders (Köhler et al., 2017). …”

Section: Discussionmentioning

confidence: 99%

Low tumor necrosis factor‐α levels predict symptom reduction during electroconvulsive therapy in major depressive disorder

et al. 2018

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ObjectiveChanges in the tumor necrosis factor‐α (TNFα) have been associated with major depressive disorder (MDD). Findings concerning the effects of electroconvulsive therapy (ECT) on the TNFα level have been contradictory. The aim was to examine the immediate and long‐term changes in the TNFα level and their associations with symptom reduction in patients with MDD during ECT.MethodThe study included 30 patients with MDD. Their TNFα levels were measured at baseline and 2 and 4 hr after the first, fifth and last ECT session. Depressive symptoms were assessed with the Montgomery‐Asberg Depression Rating Scale (MADRS).ResultsThe TNFα level decreased from baseline to the 2‐ and 4‐hr measurements. There was a correlation between the first ECT session TNFα levels and the relative symptom reduction according to the MADRS score after the ECT series. Both the first (baseline) ECT and 4‐hr TNFα levels were lower in responders than in nonresponders.Conclusion ECT consistently induced a decrease in the TNFα level after each studied session. A low TNFα level at the first ECT appeared to predict a symptom reduction. These findings suggest that TNFα might have a role in the pathogenesis in MDD and in the mechanism of action of ECT.

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Section: Discussionmentioning

confidence: 99%

Low tumor necrosis factor‐α levels predict symptom reduction during electroconvulsive therapy in major depressive disorder

et al. 2018

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“…In regard to depression/anxiety, current evidence suggests that elevated expression of the pro-inflammatory cytokine inter-leukin-6 (IL-6) in the periphery and downregulation of Ras-related C3 botulinum toxin substrate-1 (Rac-1) expression in the nucleus accumbens (NAc) in the brain both play key roles in desensitizing the brain reward system, thereby increasing sensitivity to stress-mediated depression/anxiety phenotypes. 35–38 As highlighted by red arrows in Figure 3B, our integrative analysis revealed that IL-6 expression is significantly inhibited by select biologically available phenolic metabolites derived from BDPP treatment, particularly 3-(3′-hydroxyphenyl)propionic acid (3-HPP), dihydrocaffeic acid (DHCA), 3′- O -Me-epicatechin-5- O -glucuronide (Me-EC-Gln), and quercetin-3- O -glucuronide (Q-Gln). Moreover, Rac-1 expression is significantly induced by malvidin-glucoside, another BDPP metabolite.…”

Section: Resultsmentioning

confidence: 99%

A Comprehensive Database and Analysis Framework To Incorporate Multiscale Data Types and Enable Integrated Analysis of Bioactive Polyphenols

Cheng

Wang

et al. 2017

Mol. Pharmaceutics

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The development of a given botanical preparation for eventual clinical application requires extensive, detailed characterizations of the chemical composition, as well as the biological availability, biological activity, and safety profiles of the botanical. These issues are typically addressed using diverse experimental protocols and model systems. Based on this consideration, in this study we established a comprehensive database and analysis framework for the collection, collation, and integrative analysis of diverse, multiscale data sets. Using this framework, we conducted an integrative analysis of heterogeneous data from in vivo and in vitro investigation of a complex bioactive dietary polyphenol-rich preparation (BDPP) and built an integrated network linking data sets generated from this multitude of diverse experimental paradigms. We established a comprehensive database and analysis framework as well as a systematic and logical means to catalogue and collate the diverse array of information gathered, which is securely stored and added to in a standardized manner to enable fast query. We demonstrated the utility of the database in (1) a statistical ranking scheme to prioritize response to treatments and (2) in depth reconstruction of functionality studies. By examination of these data sets, the system allows analytical querying of heterogeneous data and the access of information related to interactions, mechanism of actions, functions, etc., which ultimately provide a global overview of complex biological responses. Collectively, we present an integrative analysis framework that leads to novel insights on the biological activities of a complex botanical such as BDPP that is based on data-driven characterizations of interactions between BDPP-derived phenolic metabolites and their mechanisms of action, as well as synergism and/or potential cancellation of biological functions. Out integrative analytical approach provides novel means for a systematic integrative analysis of heterogeneous data types in the development of complex botanicals such as polyphenols for eventual clinical and translational applications.

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“…Some previous studies have presented data supporting similar outcomes. In a Norwegian study among schizophrenic ( n = 344) and nonschizophrenic groups ( n = 308), depression was related to LDL and TC levels, while in another study it was shown that depression was associated with elevated levels of several inflammatory cytokines [29-31]. In contrast to our results, Shah et al [32] reported that there was no association of HbA 1c , blood pressure, and LDL cholesterol with depression in adults with type 2 diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

A High-Protein/Low-Fat Diet May Interact with Vitamin D-Binding Protein Gene Variants to Moderate the Risk of Depression in Apparently Healthy Adults

et al. 2018

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Background: Recent studies have shown that depression is inversely correlated with high protein and low fat intake and positively correlated with vitamin D-binding protein (VDBP). Therefore, the aim of this study was to examine the interaction between protein/fat dietary patterns and VDBP genotypes with regard to the risk of depression in apparently healthy adults who have not been diagnosed with any chronic disease. Methods: In this study, 265 individuals (126 males and 139 females) aged 18–55 years were recruited from the communities of central and west Tehran based on convenience sampling. Body composition was measured with a body composition analyzer and depression symptoms were categorized as normal, moderate depression, or severe depression using the Depression Anxiety Stress Scales 21 (DASS-21) questionnaire. Dietary patterns were determined by a semiquantitative food frequency questionnaire to assess typical food intake during the 12-month period. Blood samples were collected from and biochemical measurements performed on all participants. An analysis of two polymorphisms (rs7041 and rs4588) in the GC gene, which encodes VDBP, was performed by polymerase chain reaction-restriction fragment length polymorphism. Results: A statistically significant association was found between depression and diet (p = 0.03) after having categorized the participants into three groups: a high-protein/low-fat (HP/LF) group, a moderate-protein/moderate-fat (MP/MF) group, and a low-protein/high-fat (LP/HF) group. Moreover, the findings demonstrated that depression was related to both the rs7041 and the rs4588 polymorphism (p = 0.05 and p = 0.02, respectively). We next used multinomial logistic modeling to investigate the risk of depression. A significant interaction was observed between HP/LF diet and the rs7041 polymorphism in the moderate- and severe-depression groups (β = –0.30, p = 0.05, and β = –0.48, p = 0.01, respectively). Conclusion: This study showed that an HP/LF diet interacts with the rs7041 polymorphism, with T allele carriers having a greater prevalence of moderate and severe depression.

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Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies

Cited by 1,103 publications

References 74 publications

Low tumor necrosis factor‐α levels predict symptom reduction during electroconvulsive therapy in major depressive disorder

Low tumor necrosis factor‐α levels predict symptom reduction during electroconvulsive therapy in major depressive disorder

A Comprehensive Database and Analysis Framework To Incorporate Multiscale Data Types and Enable Integrated Analysis of Bioactive Polyphenols

A High-Protein/Low-Fat Diet May Interact with Vitamin D-Binding Protein Gene Variants to Moderate the Risk of Depression in Apparently Healthy Adults

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