Peripheral distribution of amoxicillin in sheep and influence of local inflammation

Delis, Georgios; Koutsoviti-Papadopoulou, M.; Theodosiadou, Ekaterini; Kounenis, G.; Batzias, Georgios

doi:10.1016/j.tvjl.2009.06.005

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…Although remarkable differences between muscular clusters could be observed, amoxicillin removal from tissues was so rapid that this panorama could profoundly change within short periods of time during the initial portions of the withdrawal period, thereby explaining these discrepancies. Rapid depletion from tissues has also been described in other species following several different methods of administration, for instance, in fish [29] and in sheep [30]. Figure 4 shows a rapid withdrawal of amoxicillin from muscle ( Figure 4a) and blood ( Figure 4b) that reached amounts close to the MRL (50 µg/kg) in the first day of the withdrawal period.…”

Section: Amoxicillinmentioning

confidence: 55%

Is Blood a Good Indicator for Detecting Antimicrobials in Meat? Evidence for the Development of In Vivo Surveillance Methods

et al. 2020

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The introduction of antimicrobial residues in the food chain has a significant impact on human health. An innovative solution to avoid their presence in meat is the adaptation of current control methods for use with in vivo matrixes. Thus, the aim was to obtain paired blood and muscle samples from pigs treated with some of the main antimicrobials currently used in veterinary medicine (oxytetracycline, sulfamethoxypyridazine, enrofloxacin, amoxicillin), and to compare their rate of depletion in both matrixes. Antimicrobial concentrations in paired samples of blood and muscle were determined by liquid chromatography with tandem mass spectrometry (LC–MS/MS) or high performance liquid chromatography with fluorescence detection (HPLC-FLD). A comparison between values obtained in muscle and blood showed a similar distribution in both matrixes for oxytetracycline; for sulfamethoxypyridazine, a similar decrease rate but a concentration three times higher in blood compared to muscle was found; for enrofloxacin, we found significant differences in the rate of depletion, with similar antimicrobial concentrations in both matrixes with values close to the maximum residue limit (MRL) and higher amounts in muscle for values that lay considerably over the MRL. Conversely, amoxicillin depletion was so rapid that its appearance in carcasses does not seem to pose a risk. Therefore, blood would be a feasible matrix for the development of new in vivo tests.

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Section: Amoxicillinmentioning

confidence: 55%

Is Blood a Good Indicator for Detecting Antimicrobials in Meat? Evidence for the Development of In Vivo Surveillance Methods

et al. 2020

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“…AMX is widely used in all forms of livestock (Belmar-Liberato et al, 2011), mainly for the treatment of severe respiratory, gastrointestinal, urinary, dermal, and dental infections. Its widespread use is because of its good absorption, penetration into tissues, and rapid bactericidal activity (Anadon et al, 1996;Delis et al, 2010;Sinphithakkul et al, 2016). Its pharmacokinetic behavior has been studied in different ruminant species such as sheep (Craigmill et al, 1992;Carceles et al, 1995;Elsheikh et al, 1999;Fernandez et al, 2007;Delis et al, 2010), goats (Craigmill et al, 1992;Carceles et al, 1995;Escudero et al, 1996;Khargharia et al, 2012), cattle (Rutgers et al, 1980), and buffalo calves (Khanikor et al, 1986;Rasheed et al, 2013) but in this latter species, the pharmacokinetic data are limited.…”

mentioning

confidence: 99%

Pharmacokinetics of amoxicillin trihydrate in Thai swamp buffaloes (Bubalus bubalis): a pilot study

Ruennarong

Wongpanit

Sakulthaew

et al. 2016

Vet Pharm & Therapeutics

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This study aimed to investigate the pharmacokinetic characteristics of amoxicillin (AMX) in Thai swamp buffaloes, Bubalus bubalis, following single intramuscular administration at two dosages of 10 and 20 mg/kg body weight (b.w.). Blood samples were collected at assigned times up to 48 h. The plasma concentrations of AMX were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The concentrations of AMX in the plasma were determined up to 24 h after i.m. administration at both dosages. The C values of AMX were 3.39 ± 0.18 μg/mL and 6.16 ± 0.18 μg/mL at doses of 10 and 20 mg/kg, respectively. The AUC values increased in a dose-dependent fashion. The half-life values were 5.56 ± 0.40 h and 4.37 ± 0.23 h at doses of 10 and 20 mg/kg b.w, respectively. Based on the pharmacokinetic data and PK-PD index (T > MIC), i.m. administration of AMX at a dose of 20 mg/kg b.w might be appropriate for the treatment of susceptible Mannheimia haemolytica infection in Thai swamp buffaloes.

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Pharmacodynamics of amoxicillin against Mannheimia haemolytica and Pasteurella multocida and pharmacokinetic/pharmacodynamic (PK/PD) correlation in sheep

Delis

Koutsoviti-Papadopoulou

Siarkou

et al. 2010

Research in Veterinary Science

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Peripheral distribution of amoxicillin in sheep and influence of local inflammation

Cited by 4 publications

References 46 publications

Is Blood a Good Indicator for Detecting Antimicrobials in Meat? Evidence for the Development of In Vivo Surveillance Methods

Is Blood a Good Indicator for Detecting Antimicrobials in Meat? Evidence for the Development of In Vivo Surveillance Methods

Pharmacokinetics of amoxicillin trihydrate in Thai swamp buffaloes (Bubalus bubalis): a pilot study

Pharmacodynamics of amoxicillin against Mannheimia haemolytica and Pasteurella multocida and pharmacokinetic/pharmacodynamic (PK/PD) correlation in sheep

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