Peripheral distribution of the canine A-V conduction system

Uhley, Herman N.; Rivkin, Laurence M.

doi:10.1016/0002-9149(60)90137-5

Cited by 44 publications

(12 citation statements)

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“…The His bundle splits into the right and left bundle branches, which on their turn divide first into a few major branches (fascicles) and subsequently into a network of subendocardially located Purkinje fibers. [15][16][17] In the LV, these Purkinje fibers form a network in the lower third of the septum and free wall, which also covers the papillary muscles. 15,17 There are significant interspecies differences in the size and extent of the rapid conduction system.…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17] In the LV, these Purkinje fibers form a network in the lower third of the septum and free wall, which also covers the papillary muscles. 15,17 There are significant interspecies differences in the size and extent of the rapid conduction system. In hearts from ox and sheep, the bundles were significantly thicker and their branches extended much more towards the epicardium than in hearts from dog, pig, and man.…”

Section: Introductionmentioning

confidence: 99%

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Relation Between the Pacing Induced Sequence of Activation and Left Ventricular Pump Function in Animals

Prinzen

Peschar

2002

Pacing Clinical Electrophis

253

195

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The main goal of this article was to review animal experimental work on the effect of asynchronous activation on ventricular pump function. During normal sinus rhythm and atrial pacing, the Purkinje system contributes significantly to the rapid electrical activation of the ventricles. In contrast, during ventricular pacing the impulse is almost exclusively conducted through the normal myocardium. As a consequence, electrical activation of the ventricles becomes asynchronous and has an abnormal sequence. The abnormal impulse conduction causes considerable disturbances to occur in regional systolic fiber shortening, mechanical work, blood flow, and oxygen consumption; low values occurring in early activated regions and values above normal being present in late activated regions. Many animal studies have now shown that the abnormal electrical activation, induced by ventricular pacing, leads to a depression of systolic and diastolic LV function. Pacing at the right ventricular apex (the conventional pacing site) reduces LV function more than pacing at the high ventricular septum or at LV sites. In canine hearts with experimental LBBB, LV pacing significantly improves LV pump function. Differences in LV pump function between (combinations of) pacing sites are poorly correlated with QRS duration. Therefore, the cause of the depression of LV function during abnormal electrical activation appears to be a combination of the asynchrony and the sequence of activation. These experimental findings justify continuing attention for optimizing the site(s) of ventricular pacing in patients with normal and abnormal ventricular impulse conduction.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relation Between the Pacing Induced Sequence of Activation and Left Ventricular Pump Function in Animals

Prinzen

Peschar

2002

Pacing Clinical Electrophis

253

195

View full text Add to dashboard Cite

show abstract

“…Most of the free wall in the canine ventricle has a thin diffuse Purkinje fiber net beneath thc endocardium and covering the ventricular muscle fibers (Kugler and Parkin 1956;Uhley and Rivkin 1960). A conduction delay of several milliseconds between Purkinje fibers and ventricular fibers recorded from the transmembrane action potentials has been reported previously (Matsuda and Kamiyama 1965;Matsuda et al 1967;Mendez et al 1970).…”

Section: Discussionmentioning

confidence: 67%

“…Electrophysiological localization of the Purkinje net was confirmed by staining with Lugol's solution (Uhley and Rivkin 1960), in the preparation after the experiment.…”

Section: Preparationmentioning

confidence: 99%

Conduction Delay from Purkinje Fiber to Ventricular Muscle Studied with Extracellular Microelectrodes

Kamiyama¹,

Inoue²

1971

Can. J. Physiol. Pharmacol.

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KAMIYAMA, A., and INOUE, F. 1971. Conduction delay from Purkinje fiber to ventricular muscle studied with extracellular microelectrodes. Can. J. Physiol. Pharmacol. 49, 678-684.The relationship between electrical activity recorded intracellularly and extracellularly was studied in canine right ventricle. When the tip of a microelectrode was placed against a Purkinje fiber the electrical activity obtained had two components. The first component was a sharp diphasic wave which was defined as an action current while the second component was a rounded and flat diphasic wave which was defined as a field potential. Transmembrane action potentials recorded at the same site indicated that the first component was an active membrane current of the Purkinje fiber while the second component was identified as the field effect potential generated by ventricular fibers lying directly under the layer of Purkinje fibers. In areas where the Purkinje fibers were absent only the second component was present. The time delay of approximately 5 ms between the two components represents the conduction delay of the impulse from the Purkinje fiber to the ventricular fiber. KAMIYAMA,A,, et INOUE, F. 1971. Conduction delay from Purkinje fiber to ventricular muscle studied with extracellular microelectrodes. Can. I. Physiol. Pharmacol. 49, 678-684. Sur des fragments de tissus ventriculaire droit, nous avons ttudit les relations entre I'activitC tlectrique intra et extracellulaire. Lorsque la pointe de la microtlectrode est positionnte au dessus d'une cellule de Purkinje, I'activitk tlectrique enregistrte prtsente deux composantes. La premihre, dCfinie comme un courant d'action, est constitute d'une onde rapide et diphasique.La seconde consiste en une onde diphasique lente et rtsulte d'un champ de potentiel. Par comparaison avec I'activitt Clectrique intracellulaire, il apparai"t que la premihre composante rtsulte d'un courant membranaire des cellules de Purkinje tandis que la second risulte d'un champ de potentiel crtC par les fibres ventriculaires sous-jacentes. Au niveau des regions dtpourvues de cellules de Purkinje, seule la seconde composante est enregistrte. La latence entre les deux composantes est de l'ordre de 5m sec reprtsentant le temps de conduction de I'influx entre les cellules de Purkinje et les cellules ventriculaires.

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“…Recently, TAUFIC et al (1954), ALLEN et al (1959 developed Iodine-glycogen reaction for the study of the atrioventricular system, based on the fact that much glycogen is present in the Purkinje fiber. By this method, UHLEY et al (1960), SPACH et al (1963), BAERG and BASETT (1963 and others observed the atrioventricular system of the dog. SPACH et al (1963) studied electrical activities of vitally stained Purkinje fibers, and discussed the physiological meaning of the conduction system.…”

Section: Discussionmentioning

confidence: 91%

Morphological and Histochemical Studies on the Cardiac Conduction System of the Dog

Hara

1967

Arch. Histol. Jap., Arch. Histol. Jpn

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Peripheral distribution of the canine A-V conduction system

Cited by 44 publications

References 12 publications

Relation Between the Pacing Induced Sequence of Activation and Left Ventricular Pump Function in Animals

Relation Between the Pacing Induced Sequence of Activation and Left Ventricular Pump Function in Animals

Conduction Delay from Purkinje Fiber to Ventricular Muscle Studied with Extracellular Microelectrodes

Morphological and Histochemical Studies on the Cardiac Conduction System of the Dog

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