Peripheral nerve injury impairs the ability to maintain behavioural flexibility following acute stress in the rat

Mack, David; Kendig, Michael D.; Kang, James W.M.; Gemikonakli, Gizem; Austin, Paul J.; Kalman, Eszter; Corbit, Laura H.

doi:10.1016/j.bbr.2017.04.003

Cited by 12 publications

(23 citation statements)

References 38 publications

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“…Peripheral nerve injury leads to enhanced serotonergic and dopaminergic activity in rats (Sagheddu et al., ), and increased dopaminergic activity is also found in the striatum of humans with chronic neuropathic pain (Borsook et al., ; Gao, Jeaugey, Pollak, & Benabid, ; Hagelberg et al., , ; Jaaskelainen et al., ; Lin, Wu, Chandra, & Tsay, ). Taken together, this suggests that monoamine regulation of the dorsal striatum might contribute to the impaired sensitivity to devaluation and reduced motivational drive we reported in nerve‐injured rats following a mild stress (Mor et al., ). We predicted that monoamine changes following a mild stressor in naïve rats would manifest as an enhanced activity in the DMS and inhibition in the DLS.…”

Section: Introductionmentioning

confidence: 54%

“…Furthermore, the stress impact on cognitive function is independent from the effects of the pain intensity (Hart, Wade, & Martelli, ; Povedano, Gascon, Galvez, Ruiz, & Rejas, ). We reported recently in the rat that chronic constriction injury (CCI) of the sciatic nerve did not reduce goal‐directed control over behaviour in an outcome devaluation test (Mor et al., ). However, when subjected to a mild stress (15‐min restraint) immediately prior to testing, nerve‐injured rats showed impaired goal‐directed control over behaviour.…”

Section: Introductionmentioning

confidence: 99%

“…In naïve rats, this stressor did not reduce instrumental responding and slightly enhanced goal‐directed behaviour. Yet these processes were impaired in rats with a peripheral nerve injury and, to a lesser extent, those given a sham‐surgery (Mor et al., ).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, this paper reports the behavioural data from the three groups of rats euthanased immediately after the outcome devaluation test. The behavioural data of the remaining six groups (those not given restraint and those euthanised 2‐hr after testing) have been published previously (Mor et al., ).…”

Section: Introductionmentioning

confidence: 99%

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Altered monoamine levels in the dorsal striatum of the rat are associated with alterations in behavioural selection and motivation following peripheral nerve injury and acute stress

Gemikonakli

Keay

Kendig

et al. 2019

Eur J of Neuroscience

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Chronic neuropathic pain and psychological stress interact to compromise goal‐directed control over behaviour following mild psychological stress. The dorsomedial (DMS) and dorsolateral (DLS) striatum in the rat are crucial for the expression of goal‐directed and habitual behaviours, respectively. This study investigated whether changes in monoamine levels in the DMS and DLS following nerve injury and psychological stress reflect these behavioural differences. Neuropathic pain was induced by a chronic constriction injury (CCI) of the sciatic nerve in Sprague–Dawley rats. Acute stress was induced using a 15‐min restraint. Behavioural flexibility was assessed using the outcome devaluation paradigm. Noradrenaline, serotonin, dopamine and associated metabolites were measured bilaterally from the DLS and DMS. In uninjured rats, restraint increased dopaminergic markers in the left and serotonergic markers in the right of both the DMS and DLS, indicating a possible left hemisphere‐mediated dominance. CCI led to a slightly different lateralised effect, with a larger effect in the DMS than in the DLS. Individual differences in behavioural flexibility following CCI negatively correlated with dopaminergic markers in the right DLS, but positively correlated with these markers in the left DMS. A combination of CCI and restraint reduced behavioural flexibility, which was associated with the loss of the left/DMS dominance. These data suggest that behavioural flexibility following psychological stress or pain is associated with a left hemisphere dominance within the dorsal striatum. The loss of behavioural flexibility following the combined stressors is then associated with a transition from left to right, and DMS to DLS dominance.

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Section: Introductionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Altered monoamine levels in the dorsal striatum of the rat are associated with alterations in behavioural selection and motivation following peripheral nerve injury and acute stress

Gemikonakli

Keay

Kendig

et al. 2019

Eur J of Neuroscience

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“…Experiments were carried out according to previously described method (Mor et al, 2017). SD rat were orally treated with BBE.…”

Section: Formalin Testmentioning

confidence: 99%

Antioxidant Effects ofBerchemia berchemiaefoliain Nerve Pain Models

Lee

Hyun

Choi

2017

BSL

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Berchemia berchemiaefolia (BB) are climbing plants or small to medium-sized trees that live in Africa, Asia and America. We performed the present study to investigate whether oral administration of Berchemia berchemiaefolia extract (BBE) protects SD rats from pain. The SD rat experimental groups were divided into four groups. Two of the animal model groups were fed on BBE (200 mg/kg or 100 mg/kg). We performed oral acute toxicity test to determine the optimal oral dose of BBE. To explore if BBE alleviated pain in the SD rat, we undertook the tail flick latency test and formalin test. Additionally, we conducted the anti-oxidative test. The findings of the present study suggest that Berchemia berchemiaefolia extract exhibits strong antioxidant and analgesic activities.

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Spatial working memory in a disappearing object task is impaired in female but not male dogs with chronic osteoarthritis

Smith,

Murrell,

Mendl

2024

Anim Cogn

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Chronic pain in humans is associated with impaired working memory but it is not known whether this is the case in long-lived companion animals, such as dogs, who are especially vulnerable to developing age-related chronic pain conditions. Pain-related impairment of cognitive function could have detrimental effects on an animal’s ability to engage with its owners and environment or to respond to training or novel situations, which may in turn affect its quality of life. This study compared the performance of 20 dogs with chronic pain from osteoarthritis and 21 healthy control dogs in a disappearing object task of spatial working memory. Female neutered osteoarthritic dogs, but not male neutered osteoarthritic dogs, were found to have lower predicted probabilities of successfully performing the task compared to control dogs of the same sex. In addition, as memory retention interval in the task increased, osteoarthritic dogs showed a steeper decline in working memory performance than control dogs. This suggests that the effects of osteoarthritis, and potentially other pain-related conditions, on cognitive function are more clearly revealed in tasks that present a greater cognitive load. Our finding that chronic pain from osteoarthritis may be associated with impaired working memory in dogs parallels results from studies of human chronic pain disorders. That female dogs may be particularly prone to these effects warrants further investigation.

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Peripheral nerve injury impairs the ability to maintain behavioural flexibility following acute stress in the rat

Cited by 12 publications

References 38 publications

Altered monoamine levels in the dorsal striatum of the rat are associated with alterations in behavioural selection and motivation following peripheral nerve injury and acute stress

Altered monoamine levels in the dorsal striatum of the rat are associated with alterations in behavioural selection and motivation following peripheral nerve injury and acute stress

Antioxidant Effects ofBerchemia berchemiaefoliain Nerve Pain Models

Spatial working memory in a disappearing object task is impaired in female but not male dogs with chronic osteoarthritis

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