Peripheral nerve regeneration by thiolated chitosan hydrogel containing Taurine: In vitro and in vivo study

Ehtermi, Arian; Kolarijani, Nariman Rezaei; Nazarnezhad, Simin; Alizadeh, Morteza; Masoudi, Alireza; Salehi, Majid

doi:10.1177/08839115221085736

Cited by 11 publications

(3 citation statements)

References 46 publications

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“…), polysaccharides (hyaluronic acid, chitosan, etc. ), and polyesters (P3HB and PHBV) improve cell-scaffold interaction, facilitating tissue regeneration ( Arslantunali et al, 2014 ; Ehterami et al, 2022 ). Biodegradable polymeric nerve conduits based on copolymers like poly-L lactide, polyurethane, and polyglycolic acid show promise as ideal scaffolds due to their bio-absorbability and mechanical characteristics ( Cingolani et al, 2018 ; Ehterami et al, 2021 ).…”

Section: Nerve Repair With Tissue Engineering Scaffoldsmentioning

confidence: 99%

Nerve regeneration using decellularized tissues: challenges and opportunities

Mahdian,

Tabatabai,

Abpeikar

et al. 2023

Front. Neurosci.

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In tissue engineering, the decellularization of organs and tissues as a biological scaffold plays a critical role in the repair of neurodegenerative diseases. Various protocols for cell removal can distinguish the effects of treatment ability, tissue structure, and extracellular matrix (ECM) ability. Despite considerable progress in nerve regeneration and functional recovery, the slow regeneration and recovery potential of the central nervous system (CNS) remains a challenge. The success of neural tissue engineering is primarily influenced by composition, microstructure, and mechanical properties. The primary objective of restorative techniques is to guide existing axons properly toward the distal end of the damaged nerve and the target organs. However, due to the limitations of nerve autografts, researchers are seeking alternative methods with high therapeutic efficiency and without the limitations of autograft transplantation. Decellularization scaffolds, due to their lack of immunogenicity and the preservation of essential factors in the ECM and high angiogenic ability, provide a suitable three-dimensional (3D) substrate for the adhesion and growth of axons being repaired toward the target organs. This study focuses on mentioning the types of scaffolds used in nerve regeneration, and the methods of tissue decellularization, and specifically explores the use of decellularized nerve tissues (DNT) for nerve transplantation.

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Section: Nerve Repair With Tissue Engineering Scaffoldsmentioning

confidence: 99%

Nerve regeneration using decellularized tissues: challenges and opportunities

Mahdian,

Tabatabai,

Abpeikar

et al. 2023

Front. Neurosci.

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“…It has been indicated that a scaffold pore size in the range of 100-400 μm is favorable for cell colonization, proliferation, and penetration [9]. Chitosan (CS) is well-known to be excellent in biocompatibility, biodegradability, antimicrobial property, wound healing, cell proliferation, and tissue regeneration, is a linear polysaccharide composed of glucosamine and N-acetyl glucosamine with β, 1-4 glycosidic linkages; the latter is a moiety of glycosaminoglycans [10]. It is known that during the biomineralization processes living organisms are able to crystallize and deposit a wide range of minerals.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Mechanical Properties of Chitosan/FHA Scaffolds

Salehi

Molzemi

2023

Advances in Polymer Technology

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Fluor-hydroxyapatite (FHA) is a biomaterial with dental and orthopedic potential that is highly regarded as a result of bioactivity and high biocompatibility. Chitosan is used as a growth promoting agent in the tissues of the tooth and bone. Composite scaffold from these biomaterials is used as a pattern of natural bone and tooth grafts in tissue engineering. In this study FHA was synthesized through coprecipitation method. Then chitosan/FHA composites with different amounts of FHA (15 and 30 wt%) were prepared via freeze drying way. Structural and physical characteristics of the scaffolds were determined by powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) spectra, and morphological properties of the scaffolds were investigated using SEM evaluation. The compressive strength, water-uptake capacity, and biodegradation behavior of scaffolds were performed, as well. The results indicated that chitosan/30%FHA scaffold showed more compressive strength, lower biodegradation in phosphate buffer solution after 4 weeks. Therefore, it might be a suitable scaffold for tooth engineering.

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“…12 Chitosan is a natural biodegradable polymer; it is mainly a linear polymer consisting of 2-amino-2-deoxy-d-glucopyranose structural units that linked to gather by 1,4-glycosidic bonds. 13 It is characterized by the abundance of amino and hydroxyl groups, allowing it to be used as a natural adsorbent for the removal of pollutants. 14 One of chitosan’s most important bioactivities is anti-microbial activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel chitosan Schiff base and its ZnO nanocomposite for removal of synthetic dye, antimicrobial, and cytotoxicity activity

Gaafar

El‐Taweel

Fouda

et al. 2022

Journal of Bioactive and Compatible Polymers

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In this work, a novel chitosan Schiff base 4-(2-Hydroxyaniline)pent-3-en-2-one chitosan (2-HyA-CS) and its ZnO nanocomposite (2-HyA-CS/ZnO) were sensitized and characterized by appropriate methods; FTIR, XRD, Elemental analysis, SEM, TEM and TGA. The result of characterization methods confirms the preparation of 2-HyA-CS and 2-HyA-CS/ZnO. The SEM images reveal that chitosan, 2-HyA-CS, and 2-HyA-CS/ZnO have a varied roughness and porous surfaces. The reason for this difference was attributed to the formation of Schiff base 2-HyA-CS and the presence of ZnO nanoparticles in 2-HyA-CS/ZnO. The patterns of XRD and FTIR confirm the formation of 2-HyA-CS and 2-HyA-CS/ZnO. The degree of substitution (DS) of modified chitosan 2-HyA-CS was calculated using Elemental analysis and FTIR.ATR, it was found to be 74%. The adsorption efficiency of the produced adsorbents was compared with pure chitosan to remove of Remazol Brilliant Blue R (RBBR) from an aqueous medium and antimicrobial activity. The removal percentage of RBBR by chitosan, 2-HyA-CS, and 2-HyA-CS/ZnO are 47.12%, 91.9%, and 96.56%, respectively with the following order: 2-HyA-CS/ZnO > 2-HyA-CS > chitosan. Their antimicrobial activities were studied against two Gram negative bacteria ( E. coli and P. aeruginosa), two Gram positive bacteria ( S. aureus and B. cereus) and ( C. albicans) as a yeast strain, the inhibitory zone measurements revealed that the activity of 2-HyA-CS/ZnO is excellent and higher than 2-HyA-CS and pure chitosan. The cytotoxicity of the prepared compound 2-HyA-CS and 2-HyA-CS/ZnO along with pure chitosan was estimated against two human cancer cells MCF-7 cells and HepG-2 cells, the result indicates that 2-HyA-CS/ZnO having higher Inhibitory activity against both MCF-7 and HepG-2 cells with 53.5 ± 2.86 and 27.4 ± 1.23 µg/mL respectively and 2-HyA-CS possessing moderate Inhibitory activity against both MCF-7 and HepG-2 cancer cells with IC50 = 216.5 ± 7.48 and 135.6 ± 6.49 µg/ml respectively.

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Peripheral nerve regeneration by thiolated chitosan hydrogel containing Taurine: In vitro and in vivo study

Cited by 11 publications

References 46 publications

Nerve regeneration using decellularized tissues: challenges and opportunities

Nerve regeneration using decellularized tissues: challenges and opportunities

Fabrication and Mechanical Properties of Chitosan/FHA Scaffolds

Synthesis of novel chitosan Schiff base and its ZnO nanocomposite for removal of synthetic dye, antimicrobial, and cytotoxicity activity

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