Peripheral nerve repair using a poly(organo)phosphazene tubular prosthesis

Langone, Francesco; Lora, S.; Veronese, Francesco M.; Caliceti, Paolo; Parnigotto, Pier Paolo; Valenti, Fabio; Palma, G.

doi:10.1016/0142-9612(95)93851-4

Cited by 125 publications

(53 citation statements)

References 44 publications

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“…Autologous tissues (including nerves, arteries, veins and muscles) and other biological materials (mesothelium, collagen) were progressively substituted by synthetic polymer conduits made of silicon, 11 acrylic copolymers, 10 polylactic acid, 21-23 polyglycolic acid, 24 poly(lactide-co--caprolactone), 8,25 and polyorganophosphazene. 26 Although some interesting results were reported, none of these materials surpassed the effectiveness of the nerve autograft, which is still considered as the gold clinical standard.…”

Section: Discussionmentioning

confidence: 99%

Peripheral nerve regeneration using bioresorbable macroporous polylactide scaffolds

Maquet

Martin

Malgrange

et al. 2000

J. Biomed. Mater. Res.

127

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The ability of DRG-derived neurons to survive and attach onto macroporous polylactide (PLA) foams was assessed in vitro. The foams were fabricated using a thermally induced polymer-solvent phase separation. Two types of pore structures, namely oriented or interconnected pores, can be produced, depending on the mechanism of phase separation, which in turn can be predicted by the thermodynamics of the polymer-solvent pair. Coating of the porous foams with polyvinylalcohol (PVA) considerably improved the wettability of the foams and allowed for cell culture. The in vitro biocompatibility of the PVA-coated supports was demonstrated by measuring cell viability and neuritogenesis. Microscopic observations of the cells seeded onto the polymer foams showed that the interconnected pore networks were more favorable to cell attachment than the anisotropic ones. The capacity of highly oriented foams to support in vivo peripheral nerve regeneration was studied in rats. A sciatic nerve gap of 5-mm length was bridged with a polymer implant showing macrotubes of 100 microm diameter. At 4 weeks postoperatively, the polymer implant was still present. It was well integrated and had restored an anatomic continuity. An abundant cell migration was observed at the outer surface of the polymer implant, but not within the macrotubes. This dense cellular microenvironment was found to be favorable for axogenesis.

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Section: Discussionmentioning

confidence: 99%

Peripheral nerve regeneration using bioresorbable macroporous polylactide scaffolds

Maquet

Martin

Malgrange

et al. 2000

J. Biomed. Mater. Res.

127

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“…The rate of biodegradation of nerve guides should be in accordance with axonal growth rates, 3 and researchers are still developing new types of biodegradable nerve conduits. [4][5][6][7] The aim of this study was to evaluate the use of a biodegradable nerve guide constructed of poly(DL-lactide-⑀-caprolactone) [p( 50 / 50 ( 85 / 15 L / D )LA/⑀CL)] for the reconstruction of a nerve gap. Speed and quality of nerve regeneration were compared with those of an autologous nerve graft.…”

Section: Microsurgery 17:348-357 1996mentioning

confidence: 99%

Poly(DL-lactide-ε-caprolactone) nerve guides perform better than autologous nerve grafts

et al. 1996

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The aim of this study was to compare the speed and quality of nerve regeneration after reconstruction using a biodegradable nerve guide or an autologous nerve graft. We evaluated nerve regeneration using light microscopy, transmission electron microscopy and morphometric analysis. Nerve regeneration across a short nerve gap, after reconstruction using a biodegradable nerve guide, is faster and qualitatively better, when compared with nerve reconstruction using an autologous nerve graft. Therefore, we conclude that in the case of a short nerve gap (1 cm), reconstruction should be carried out using a biodegradable nerve guide constructed of a copolymer of DL-lactide and epsilon-caprolactone.

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“…During the past several decades, a tremendous effort has been directed toward the development of methods for replacing lost or dysfunctional neurons following trauma or disease by means of tissue transplantation or peripheral nerve grafting [18][19][20][21][22]. A detailed understanding of the behavior of neuronal cell has attracted much attention because of its clinical importance and scientific interest.…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic behavior of cerebellar granule neurons

Hsu¹,

Huang²,

Hsieh³

et al. 2002

Electrophoresis

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The electrophoresis of cerebellar granule neurons is observed, and a theoretical model proposed to simulate its electrophoretic behavior. We assume that the surface of a neuronal cell carries dissociable acidic functional groups, and the liquid phase contains a mixed (a:b) + (c:b) electrolyte, where a and c are the valences of cations and b is the valence of anions. The cations of valence c are allowed to bind to dissociated functional groups. The model proposed is readily applicable to the prediction of the surface properties of cerebellar granule neurons such as the density of dissociable functional groups and the equilibrium constant of the dissociation reaction. The applicability of the present model is justified by fitting it to the measured electrophoretic mobility data.

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Peripheral nerve repair using a poly(organo)phosphazene tubular prosthesis

Cited by 125 publications

References 44 publications

Peripheral nerve regeneration using bioresorbable macroporous polylactide scaffolds

Peripheral nerve regeneration using bioresorbable macroporous polylactide scaffolds

Poly(DL-lactide-ε-caprolactone) nerve guides perform better than autologous nerve grafts

Electrophoretic behavior of cerebellar granule neurons

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