1994
DOI: 10.1111/j.1432-1033.1994.tb20074.x
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Peripheral Nerve Sphingomyelin and Cerebroside are Both Formed Via two Metabolically and Kinetically Distinct Pathways In vivo

Abstract: We have studied the labeling kinetics of peripheral nerve sphingolipids in vivo. The kinetic analysis of the labeling profiles observed for the various sphingolipids demonstrated that 90% of cerebrosides, but only 30% of sphingomyelin, were synthesized via a de novo synthesized ceramide intermediate following the injection of 1-4 pmol [3H]palmitate into mouse sciatic nerves. The remaining sphingolipid labeling (30% of the total) was due to direct acylation events, using free fatty acids originating from a pool… Show more

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Cited by 9 publications
(12 citation statements)
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“…We demonstrated the application of mental events (15)(16)(17). More recently, ceramides have this method for profiling the composition of ceramides in a commercial preparation of bovine brain cera-been implicated as possible second messengers in a vamides and, following minimal chromatographic sepa-riety of cell surface receptor-mediated signal transducration, a lipid extract of cultured T cells.…”
Section: Low As 25 Nm (25 Fmol/ml) These Reporter Ions Werementioning
confidence: 99%
“…We demonstrated the application of mental events (15)(16)(17). More recently, ceramides have this method for profiling the composition of ceramides in a commercial preparation of bovine brain cera-been implicated as possible second messengers in a vamides and, following minimal chromatographic sepa-riety of cell surface receptor-mediated signal transducration, a lipid extract of cultured T cells.…”
Section: Low As 25 Nm (25 Fmol/ml) These Reporter Ions Werementioning
confidence: 99%
“…The reaction schemes describing the steps of the metabolic pathways envisaged in this study, as well as the corresponding global kinetic equations derived from them, are given in Scheme 1. For a complete description of the development and utilization of these models, the reader is referred to our previous report on normal nerve sphingolipid metabolism (Heape et al, 1994).…”
Section: Resultsmentioning
confidence: 99%
“…Th e la rge d i ffer ence betw ee n the valu es of the r ate consta n ts k, (7 .53 Χ 10 -3 min-') and kam (0 .25 min) i ndicates th at the t wo p ool s are kinetically distinct . (0) to the theoretical total labeling (") were determined as described by Heape et al . (1994) .…”
Section: Ffa (Substrate) Metabolismmentioning
confidence: 99%
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