Peripheral Nerve Stimulation in the Treatment of Chronic Pain Syndromes From Nerve Injury: A Multicenter Observational Study

Baldeschi, Gianni Colini; Dario, Alessandro; Carolis, Giuliano De; Luxardo, Nicola; Natale, Massimo; Nosella, Paola; Papa, Alfonso; Raggi, Massimiliano; Reverberi, Claudio

doi:10.1111/ner.12539

Cited by 24 publications

(12 citation statements)

References 16 publications

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“…Disability outcome reporting time points were specified in 3/8 studies ( Supplementary Table 5 ) utilizing the DASH which was used monthly post-injury/surgery up to 6 mo in hand sensory nerve injured patients 12 ; at 3, 6, and 12 mo postoperatively in mixed (sensory/motor) upper limb nerve injuries 13 and at 12 mo postoperatively in patients undergoing nerve transfers for upper root brachial plexus injuries. 14 The SF-36 PROMs’ usage time points for the assessment of quality of life were specified in 2/4 studies, at baseline, and then at 6 mo post-surgery 15 and at 7 time points over a 15-wk period in a drug trial to treat neuropathic pain. 11 The time points for the use of pain intensity scales VAS and NPRS since PNI or surgery was often specified (10/12 studies utilizing VAS and 5/5 studies utilizing NPRS).…”

Section: Resultsmentioning

confidence: 99%

“…VAS was used preoperatively, monthly in the first 6 mo, then every 6 mo for 2 yr 16 and preop then 1, 3, and 6 mo after surgery. 15 The NPRS was used 1 wk preop and 1, 3, and 6 mo postoperatively. 17 Neurotrophic measures were used at wide-ranging time points after injury/surgery ( Supplementary Table 8 ) with only 4/17 studies specifying time points for assessment of which 3 utilized electrophysiology.…”

Section: Resultsmentioning

confidence: 99%

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A Quantitative Systematic Review of Clinical Outcome Measure Use in Peripheral Nerve Injury of the Upper Limb

et al. 2021

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BACKGROUND Peripheral nerve injury (PNI) is common, leading to reduced function, pain, and psychological impact. Treatment has not progressed partly due to inability to compare outcomes between centers managing PNI. Numerous outcome measures exist but there is no consensus on which outcome measures to use nor when. OBJECTIVE To perform a systematic review in order to describe and classify outcome measures used in PNI. METHODS A search of Ovid Medline, Ovid Embase, Allied and Complementary Medicine Database (AMED), and CENTRAL (Cochrane Clinical Trials) was conducted. Randomized control trials (RCTs), cohort studies, and case-controlled and case series (≥5 participants) published from inception of the database until 2019 investigating adult patients with a traumatic upper limb PNI in which an outcome measurement was utilized were included. RESULTS A total of 96 studies were included (15 RCTs, 8 case-control studies, 18 cohort studies, 5 observational studies, and the remainder were case series or retrospective reviews). A total of 56 individual outcome measures were identified, utilized across 28 different countries and 7097 patients. Ten core domains were defined: sensory subjective, sensory objective, motor subjective, motor objective, sensorimotor function, psychology and well-being, disability, quality of life, pain and discomfort, and neurotrophic measures. CONCLUSION Lack of consensus on outcome measure use hinders comparison of outcomes between nerve injury centers and the development of novel treatments. Development of a core outcome set will help standardize outcome reporting, improve translation of novel treatments from lab to clinical practice, and ensure future research in PNI is more amenable to systematic review and meta-analysis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Quantitative Systematic Review of Clinical Outcome Measure Use in Peripheral Nerve Injury of the Upper Limb

et al. 2021

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“…The electrical stimulation of peripheral nerves has become a growing trend during the last decade to treat many drugresistant painful conditions (recent reviews in [1][2][3]). Chronic refractory headaches are favored targets for neuromodulation, in particular neurovascular or autonomicrelated cephalalgias, such as chronic migraine, cluster headache or hemicrania continua [4][5][6][7][8], and painful neuropathies originating in a trigeminal branch or occipital nerve [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain

et al. 2020

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Background: Stimulation of the occipital or trigeminal nerves has been successfully used to treat chronic refractory neurovascular headaches such as migraine or cluster headache, and painful neuropathies. Convergence of trigeminal and occipital sensory afferents in the 'trigeminocervical complex' (TCC) from cutaneous, muscular, dural, and visceral sources is a key mechanism for the input-induced central sensitization that may underlie the altered nociception. Both excitatory (glutamatergic) and inhibitory (GABAergic and glycinergic) mechanisms are involved in modulating nociception in the spinal and medullary dorsal horn neurons, but the mechanisms by which nerve stimulation effects occur are unclear. This study was aimed at investigating the acute effects of electrical stimulation of the greater occipital nerve (GON) on the responses of neurons in the TCC to the mechanical stimulation of the vibrissal pad. Methods: Adult male Wistar rats were used. Neuronal recordings were obtained in laminae II-IV in the TCC in control, sham and infraorbital chronic constriction injury (CCI-IoN) animals. The GON was isolated and electrically stimulated. Responses to the stimulation of vibrissae by brief air pulses were analyzed before and after GON stimulation. In order to understand the role of the neurotransmitters involved, specific receptor blockers of NMDA (AP-5), GABA A (bicuculline, Bic) and Glycine (strychnine, Str) were applied locally. Results: GON stimulation produced a facilitation of the response to light facial mechanical stimuli in controls, and an inhibition in CCI-IoN cases. AP-5 reduced responses to GON and vibrissal stimulation and blocked the facilitation of GON on vibrissal responses found in controls. The application of Bic or Str significantly reduced the facilitatory effect of GON stimulation on the response to vibrissal stimulation in controls. However, the opposite effect was found when GABAergic or Glycinergic transmission was prevented in CCI-IoN cases.

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“…Para la modulación del dolor se emplean técnicas no farmacológicas con modalidades físicas como crioterapia y electroterapia (TENS). Para alcanzar la seguridad en la movilidad (marcha), en fases iniciales se deben evaluar los grupos musculares indemnes que den estabilidad a la cintura pélvica, y, dependiendo de la seguridad de la marcha, establecer la necesidad de uso de dispositivos de asistencia en la movilidad tales como bastones (11).…”

Section: Introductionunclassified

Lesión y reparación laparoscópica de nervio obturador en linfadenectomía laparoscópica. Reporte de un caso y revisión de la literatura

Burbano-Luna

Merchán-Jiménez²,

Moreno-Capacho³

et al. 2019

Rev. Colomb. Obstet. Ginecol.

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RESUMENObjetivo: presentar el caso de una lesión del nervio obturador durante linfadenectomía laparoscópica y su reparación por la misma vía en el mismo tiempo quirúrgico, y realizar una revisión de la literatura de la presentación de este tipo de lesiones, así como de la técnica utilizada, el momento de su reparación y los resultados de la rehabilitación. Materiales y métodos: se presenta el caso de una mujer de 29 años atendida en el Instituto Nacional de Cancerología en Bogotá, Colombia, con diagnóstico clínico de carcinoma escamocelular de cérvix estadio Ib1, a quien se le practicó traquelectomía radical más linfadenectomía pélvica bilateral por el deseo de preservar la fertilidad. Durante el procedimiento se advirtió una sección completa del nervio obturador, la cual se reparó inmediatamente

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Peripheral Nerve Stimulation in the Treatment of Chronic Pain Syndromes From Nerve Injury: A Multicenter Observational Study

Cited by 24 publications

References 16 publications

A Quantitative Systematic Review of Clinical Outcome Measure Use in Peripheral Nerve Injury of the Upper Limb

A Quantitative Systematic Review of Clinical Outcome Measure Use in Peripheral Nerve Injury of the Upper Limb

Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain

Lesión y reparación laparoscópica de nervio obturador en linfadenectomía laparoscópica. Reporte de un caso y revisión de la literatura

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