Peripheral nervous system involvement in primary burning mouth syndrome—results of a pilot study

Puhakka, Antti; Forssell, Heli; Soinila, Seppo; Virtanen, Arja; Röyttä, Matias; Laine, Merja; Tenovuo, Olli; Teerijoki-Oksa, Tuija; Jääskeläinen, SK

doi:10.1111/odi.12454

Cited by 80 publications

(73 citation statements)

References 35 publications

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“…Epithelial atrophy has also been described in a study that concluded that it could lead to greater exposure of nervous terminations and the consequent symptoms described for this syndrome 61 .Low density of intraepithelial nervous fibers was observed on area and length basis in samples of the tongue dorsum mucosa 62 .…”

Section: Histological Changes In the Oral Mucosamentioning

confidence: 86%

“…Interestingly, QST may help understand the neuronal mechanisms involved in various kinds of chronic pain. These tests evaluate the function of a variety of nervous fibers and detect both sensory gains and losses, and are being adapted to investigate the intraoral somatosensory function 32,62,133 . The changes associated with BMS that have thus far been described include the reduction of thermal sensitivity and low scores for tonic painful stimuli in the oral cavity, as well as lower thresholds of pain caused by heat on the tip of the tongue, anomalies in the BR, and qualitative alterations of saliva 5 .…”

mentioning

confidence: 99%

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Burning Mouth Syndrome –Latest update

Tomattis¹,

Munerato²

2016

Int J Dentistry Res

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Introduction: Burning mouth syndrome (BMS) is characterized by a recurrent daily burning sensation with no evidence lesions in the oral mucosa. It is accompanied by subjective dry mouth and dysgeusia. The tongue is the most commonly affected site, but the condition also affects other sites in the mouth. Its etiopathogeny is multifactorial and its diagnosis is made by exclusion. Objective: This article reviews the literature about the epidemiology, etiopathogeny, and diagnosis of BMS in the past 15 years. Articles were selected from PubMed/MEDLINE, and included clinical assays, case reports, and reviews. We found 509 articles, and only 136 were chosen. The key words were: burning mouth syndrome (BMS), review, etiopathogeny, diagnosis. Conclusions: BMS remains an important diagnostic challenge, though the disease is considered a neuropathy characterized by damage to trigeminal peripheral nervous fibers, which triggers central sensitization. In addition to BMS and secondary BMS, it seems relevant to include complicated BMS, in which symptoms persist despite the elimination of local and systemic causes. BMS should be investigated by a transdisciplinary team that will take into account all aspects active in the mental and physical dimensions of the condition, in the most detailed way. Therefore, QST, imaging investigations, various evaluation scales of mental health and of the impact of BMS on quality of life as well as the investigation of sleep disorders and changes in circadian rhythm could be useful tools in the development of treatment strategies based on findings and observing the characteristics of each BMS patient in light of specifics of diagnosis.

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Section: Histological Changes In the Oral Mucosamentioning

confidence: 86%

mentioning

confidence: 99%

Burning Mouth Syndrome –Latest update

Tomattis¹,

Munerato²

2016

Int J Dentistry Res

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“…Alterations in both the central and peripheral nervous systems of BMS patients are reported using a variety of neuro-exploratory investigations 121, 122 . There are 3 subclasses of neurophysiologic pain described for BMS patients: peripheral small fiber neuropathy, subclinical major trigeminal neuropathy, and central pain possibly related to deficient dopaminergic inhibition 121, 123, 124 .…”

Section: Burning Mouth Syndrome (Bms)mentioning

confidence: 99%

Is it Sjögren's syndrome or burning mouth syndrome? Distinct pathoses with similar oral symptoms

Aljanobi

Sabharwal

Krishnakumar

et al. 2017

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Sjögren’s Syndrome (SS) and Burning Mouth Syndrome (BMS) typically present in post-menopausal women. Although these conditions have significantly different etiopathogeneses, patients with SS or BMS often present with analogous oral complaints. The similarities between the two conditions have led to considerable confusion on the part of medical and dental practitioners, and those with BMS or SS often wait years to receive a diagnosis. Therefore, it is imperative for clinicians to understand the characteristic subjective and objective features of each disease and how these can be used to distinguish them. This review will discuss the proposed etiology, clinical manifestations, histopathology, diagnostic criteria, and patient management of SS and BMS. We also identify key differences between the two pathoses that aid in establishing the correct diagnosis. Recognition of the defining features of each condition will lead to reduced time to diagnosis and improved patient management for these poorly understood conditions.

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“…Symptoms associated with BMS vary and may have a negative impact on oral health-related quality of life in patients with BMS (1). McMillan et al (2) reported that, so far, no therapy has been proven to be effective or ineffective in patients with BMS. To date, there is no clear evidence that there is dysfunction of central and/or peripheral nervous system in patients with BMS (3,4).…”

Section: Introductionmentioning

confidence: 99%

The Significance of Brain Transcranial Sonography in Burning Mouth Syndrome: a Pilot Study

Zavoreo¹,

Boras²,

Zadravec³

et al. 2017

Acta Stomatol Croat

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Peripheral nervous system involvement in primary burning mouth syndrome—results of a pilot study

Abstract: Our results in neurophysiologically optimally characterized BMS patients confirm that pure focal small fiber neuropathy of the oral mucosa has a role in the pathophysiology of primary BMS. Furthermore, BMS may be related to a more generalized, yet subclinical peripheral neuropathy.

Cited by 80 publications

References 35 publications

Burning Mouth Syndrome –Latest update

Burning Mouth Syndrome –Latest update

Is it Sjögren's syndrome or burning mouth syndrome? Distinct pathoses with similar oral symptoms

The Significance of Brain Transcranial Sonography in Burning Mouth Syndrome: a Pilot Study

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