60C arpal tunnel syndrome (CTS) is the most common peripheral neuropathy of an upper extremity, and it is caused by an entrapment of the median nerve at the level of the carpal tunnel (1). The carpal tunnel is formed by the carpal bones, which form a concave arch, and the transverse carpal ligament, which lies on the arch. The ligament is also fused to the pisiform, the hook of the hamate at the ulnar side, the tubercle of the navicular bone, the crest of the trapezium, and the radial styloid (2).CTS is a common disorder with an estimated 8% annual incidence rate, and an accurate diagnosis can be achieved by considering the patient's electrodiagnostic features and symptom characteristics. Electrodiagnostic testing is considered the single most accurate method of diagnosis, but a high rate of false negatives and positives are also well documented. If electrodiagnostic findings are not available, then the patient's characteristic symptoms and physical examination may provide the best diagnostic information (3).Fat-saturated, T2-weighted magnetic resonance imaging (MRI) can reveal morphological changes in CTS patients, such as nerve enlargement, nerve flattening, increased nerve signal intensity, and bowing of the flexor retinaculum at the level of the hamate hook. However, the sensitivity and specificity of MRI findings are low; therefore, conventional MRI may provide insufficient diagnostic data for clinically assessing CTS (1).Diffusion tensor imaging (DTI) is an advanced MRI technique that is used to measure the diffusion of water in tissue (4). In white matter, water diffusion is anisotropic due to its impermeable boundaries, and this anisotropy can be measured with DTI; therefore, its main clinical application is white-matter tract visualization, but recently, it has been shown that DTI can be useful for imaging non-neural tissue, such as peripheral nerves (5-8), muscle (9), and prostate (10). There are a few preliminary reports in the literature on the application of DTI for diagnosis of CTS, but they include a limited number of subjects. Nevertheless, these reports found decreased fractional anisotropy (FA) and increased radial diffusivity at the median nerve within the carpal tunnel (8,11,12).Here, we investigated DTI's diagnostic utility in a large group of CTS patients using two quantitative measures: FA and the apparent diffusion coefficient (ADC). We also measured the correlation between CTS severity and FA.
Materials and methods
PatientsWe prospectively evaluated 57 wrists in 38 CTS patients (34 females and 4 males; mean age, 48 years; age range, 25-73 years; median age,
MUSCULOSKELETAL IMAGING ORIGINAL ARTICLE
Diffusion tensor imaging in carpal tunnel syndromeNeslihan Taşdelen, Bengi Gürses, Özgür Kılıçkesmez, Zeynep Fırat, Geysu Karlıkaya, Mustafa Tercan, Aziz Müfit Uluğ, Ahmet Nevzat Gürmen
PURPOSEWe aimed to investigate the efficacy of diffusion tensor imaging in the diagnosis of carpal tunnel syndrome and to obtain a quantitative parameter that may contribute to the diagnosis.
MATERIALS AND METH...