1974
DOI: 10.1007/bf01945188
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Peripheral neuropathy associated with inhalation of methyl-n-butyl ketone

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1975
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Cited by 50 publications
(11 citation statements)
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“…Identical morphological findings were present in glue sniffer neuropathies, in industrial n-hexane polyneuropathies as well as in another solvent neuropathy, the methyl-butyl-ketone (MBK)-polyneuropathy [1,5,9,10,22]. 86 cases of this latter syndrome occurred in a fabric printing plant in Ohio in 1973 after methyl-isobutyl-ketone (MIBK) had been exchanged for MBK in a solvent mixture composed of methyl-ethyl-ketone (MEK) and MIBK [1,5].…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…Identical morphological findings were present in glue sniffer neuropathies, in industrial n-hexane polyneuropathies as well as in another solvent neuropathy, the methyl-butyl-ketone (MBK)-polyneuropathy [1,5,9,10,22]. 86 cases of this latter syndrome occurred in a fabric printing plant in Ohio in 1973 after methyl-isobutyl-ketone (MIBK) had been exchanged for MBK in a solvent mixture composed of methyl-ethyl-ketone (MEK) and MIBK [1,5].…”
Section: Discussionmentioning
confidence: 96%
“…After the epidemiological data as well as by means of animal experiments, MBK was identified as a neurotoxin [24,29]. A synergistic effect of MEK could not be excluded [1,10]. Inhalation studies in rats showed a weakness of all limbs lasting a few hours after the exposure to MBK alone; after the inhalation of the combination MEK/MBK, however, the weakness remained for more than 24 hours [10].…”
Section: Discussionmentioning
confidence: 96%
“…Die gleichen Symptome wurden durch Methyl-n-butylketon allein (225 ppm) erst nach 66tägiger kontinuierlicher Exposition hervorgerufen [21]. Ein ähnlicher Potenzierungseffekt wurde beobachtet, nachdem Ratten 6 Wochen lang, 5mal wöchentlich 8 Stunden täglich, einem MEK/Methyl-n-butylketon-Gemisch im Verhältnis 10: 1 (2000/200 ppm) exponiert waren [22]. Aus pharmakokinetischen Untersuchungen, ebenfalls an Ratten, geht hervor, daß eines der beiden Lösemittel den Metabolismus des anderen beeinflußt.…”
Section: Chronische Wirkungunclassified
“…In the case of 2-hexanone, there is very robust toxicity information particularly as it relates to neurotoxicity. Subchronic inhalation exposure to 2-hexanone at concentrations ranging from 200 ppm to 1600 ppm is associated with the observance of peripheral neuropathy in chickens, rats, cats, and monkeys (Abou-Donia et al 1985;Mendell et al 1974;Spencer et al 1975;Duckett et al 1974). Johnson et al (1979) reported that rats and monkeys that inhaled 100 ppm of 2-hexanone for 9 months developed abnormal neurophysiologic indicators, and this exposure was equivalent to a daily 8-hour TWA of 75 ppm.…”
Section: Toxicology Summary and Data Analysismentioning
confidence: 99%