Peripheral T‐cell lymphoma: a clinicopathological study of 41 cases and evaluation of the prognostic significance of the updated Kiel classification

Montalbán, Carlos; Obeso, G; Gallego, Almudena Muñoz; Castrillo, J. M.; Bellas, Carmen; Rivas, Carmen

doi:10.1111/j.1365-2559.1993.tb00128.x

Cited by 39 publications

(27 citation statements)

References 33 publications

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“…Most patients presented with advanced stage disease (Table 5), but with an ambulatory performance status. B symptoms were relatively uncommon (40%) when compared with other studies of PTCL [20,[38][39][40], but these did not include patients with angiocentric nasal lymphoma. However, the frequency of B symptoms in our patients with PTCL-NOS and AILT is in keeping with prior studies.…”

Section: Clinical Presentation and Outcomementioning

confidence: 91%

Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the Non-Hodgkin’s Lymphoma Classification Project

et al. 2002

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Background: Peripheral T-cell lymphoma (PTCL) is rare in most parts of the world. Therefore, we have evaluated the 96 cases of PTCL diagnosed within the Non-Hodgkin's Lymphoma Classification Project (NHLCP) (1378 cases) for their geographical distribution, pathologic features and diagnostic reliability, as well as clinical presentation and outcome. Materials and methods:Diagnoses of all cases were rendered independently by five experienced hematopathologists based on morphology only, and after introduction of the immunophenotype and clinical data. Divergent diagnoses were jointly discussed and a final consensus diagnosis was established in each case. Reliability of the diagnoses was evaluated statistically, and the clinical features and outcome were analyzed according to the consensus diagnoses.Results: Seven per cent of all non-Hodgkin's lymphoma (NHL) cases reviewed were classified as PTCL and the frequency varied from 1.5% to 18.3% in different countries. The interobserver agreement with the consensus diagnosis of PTCL was 86% in the Revised European-American Lymphoma (REAL) classification, but the designation of subtypes was less reliable. Diagnostic reliability improved from 41% to 86% after immunophenotyping, but did not improve further with the addition of detailed clinical data. Clinically, angiocentric nasal lymphoma presented in young females (median age 49 years) at extranodal sites, but with few adverse risk factors, whereas angioimmunoblastic lymphoma presented most often in older males (median age 65 years) at nodal and extranodal sites with numerous risk factors. The 5-year overall and failure-free survivals for patients with PTCL treated with doxorubicin (Adriamycin)-containing regimens were only 26% and 20%, respectively. Both failure-free and overall survival were strongly correlated with the performance status and International Prognostic Index scores at presentation, but differences in survival were not observed between the major histological types. However, within the PTCL 'not otherwise specified' category, but not angioimmunoblastic lymphoma, the number of transformed blasts was prognostically relevant. Conclusions:PTCLs can be diagnosed reliably by experienced hematopathologists, but immunophenotyping is absolutely necessary. Currently, all types of PTCL should be considered high-grade lymphomas. An increased ability to distinguish T-lymphocyte subsets is needed in order to better subclassify the PTCLs for therapeutic and prognostic purposes.

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Section: Clinical Presentation and Outcomementioning

confidence: 91%

Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the Non-Hodgkin’s Lymphoma Classification Project

et al. 2002

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“…The study group included mantle cell (MCL) and marginal zone (MZL) lymphoVet Pathol 43: 241-256 (2006) mas as were defined in humans over this period. 4,29,36,41 Phenotype was determined for 51 cases by immunohistochemical reaction to CD3 and CD79a antibodies for T-and B-cell lineages, respectively (DAKO, Carpinteria CA). Clonality was determined for 52 cases where DNA was available, including nine cases where phenotype was not determined (Table 1).…”

Section: Study Populationmentioning

confidence: 99%

“…7a). 22,36,45,49 Cytologically, TZL is composed of homogeneous population of CD3 + small lymphocytes that have sharp, shallow nuclear indentations, inapparent nucleoli, and a moderate volume of pale cytoplasm (Fig. 7b).…”

Section: Diagnostic Criteriamentioning

confidence: 99%

Canine Indolent Nodular Lymphoma

et al. 2006

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Abstract. Sixty-six cases of indolent canine lymphoid proliferation were reviewed. Age ranged from 1.5 to 16 years (median 9.0 years). Dogs of 26 breeds, plus 13 of mixed breeding or unknown lineage, were represented. B-Cell lymphomas (CD79a + ) predominated. Marginal zone lymphoma (MZL), the largest group, involved lymph node (33 cases) and spleen (13 cases), with both tissues involved in five of these cases. Follicular lymphoma (FL) involved lymph nodes (five cases), and mantle cell lymphoma (MCL) occurred as solitary splenic masses (three cases). Nodal CD3 + T-zone lymphomas (TZL) (10 cases), were included since they resembled late-stage MZL at the architectural level. Two cases of marginal zone hyperplasia (MZH) were included to aid in differentiation of early MZL. Clonality status was determined in 54 cases by analysis of immunoglobulin heavy chain (IGH) and T-cell antigen receptor gamma (TCRG) gene rearrangement. Clonal rearrangement of IGH was detected in 28 of 35 MZL cases (80%), four of four FL cases (100%) and three of three MCL cases (100%). Concurrent cross lineage rearrangement of TCRG was detected in six MZL and two FL cases. Clonal rearrangement of TCRG was documented in five of eight TZL cases (63%). Limited survival data obtained for 18 dogs indicated that the B-cell lymphomas (MZL, MCL, and FL) and the T-cell lymphoma (TZL) were associated with indolent behavior and long survival. Although to the authors' knowledge, the true incidence of canine indolent lymphomas is unknown, the tumors are not rare and may have been underrecognized. Recognition of their architectural features, routine application of immunophenotyping, and molecular clonality assessment should alleviate this.

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“…The median age of onset for PTCL-U is reported to be in the seventh decade (4,5). This lymphoma usually takes an aggressive course, with relapses being more common than for B-cell lymphomas.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Involvement of Peripheral T-cell Lymphoma, Unspecified: A Case Report

Chung

Shim

Ham

et al. 2010

J Korean Soc Radiol

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Peripheral T-cell lymphoma (PTCL) is a subtype of non-Hodgkin's lymphoma (NHL) and PTCL is quite rare in western countries: this accounting for 10 to 15% of all the case of NHL in Europe (1). Although PTCL may involve many organs, including the sino-nasal cavity and airway, intestinal tract, skin, lymph nodes and liver, it rarely involves the lung, and there are few radiological descriptions to guide making the proper diagnosis (2). We report here on a case of PTCL, unspecified (PTCL-U) that which did involve the lung parenchyma and mediastinal lymph nodes, and we present the clinical manifestations and pathological findings. Case ReportA 39-year-old man was admitted with a mild fever and cough of 3 days duration. The laboratory findings were an erythrocyte sedimentation rate (ESR) of 24 mm/hr, a C-reactive protein (CRP) level of 77 mg/L, the cytoplasmic antineutrophil cytoplasmic antibody (cANCA) was negative and the perinuclear anti-neutrophilic cytoplasmic antibody (pANCA) was negative. The chest radiography on admission revealed a cavitary lesion in the left middle lung zone (Fig. 1A). The chest CT image showed a thin-walled cavitary lesion in the superior segment of the left lower lobe (Fig. 1B). The upper level of the chest CT image, through the carina, revealed multiple lymphadenopathies in the mediastinum. The patient was treated with antibiotics and then he was discharged after the fever and cough had subsided.About 2 months later, the patient was readmitted to our hospital after 2 days of high fever. The laboratory findings were a white blood cell count of 14, 500/uL, a CRP level of 103 mg/L, the C-ANCA and P-ANCA were negative and the sputum acid-fast bacilli was negative. The antibody titer for Epstein-Barr virus was not elevated. Chest radiography showed an ill-defined consolidation in the left middle lung field and a prominent left hilum (Fig. 1C). The follow-up chest CT images showed a thick-walled cavity in the left lower lobe that was Peripheral T-cell lymphoma is a rare type of lymphoma that's derived from postthymic lymphoid T cells. Pulmonary involvement of peripheral T-cell lymphoma of the unspecified type is very rare and the imaging findings of this illness have rarely been reported. We present here a case of peripheral T-cell lymphoma of the unspecified type with a cavitary lesion in the lung parenchyma, and we pathologically confirmed this illness by performing video-assisted thoracoscopic surgery.

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Peripheral T‐cell lymphoma: a clinicopathological study of 41 cases and evaluation of the prognostic significance of the updated Kiel classification

Cited by 39 publications

References 33 publications

Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the Non-Hodgkin’s Lymphoma Classification Project

Peripheral T-cell lymphoma (excluding anaplastic large-cell lymphoma): results from the Non-Hodgkin’s Lymphoma Classification Project

Canine Indolent Nodular Lymphoma

Pulmonary Involvement of Peripheral T-cell Lymphoma, Unspecified: A Case Report

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