Peripheral Vascular Effects of Thiopental and Propofol in Humans with Artificial Hearts

Rouby, Jean-Jacques; Andreev, A; Léger, Philippe; Arthaud, M; Landault, C.; Vicaut, Éric; Maistre, G.; Eurin, Joëlle; Gandjbakch, I.; Viars, P.

doi:10.1097/00000542-199107000-00007

Cited by 121 publications

(57 citation statements)

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“…According to average values at initial moments, M0, M1 and M2, arterial pressures kept lower levels than normal, in agreement to studies on vascular effects of propofol 9 . During anesthesia with propofol, the existence of a light hypotension can be related to the combination of the following factors: peripheral vasodilatation, reduction in cardiac output, baroreflex activity inhibition and direct depression on myocardium 10 .…”

Section: Emg (%) Gi Giisupporting

confidence: 88%

Comparative study between target-controlled-infusion and continuous-infusion anesthesia in dogs treated with methotrimeprazine and treated with propofol and remifentanil

et al. 2008

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PURPOSE: To compare two propofol infusion techniques in bitches subjected to ovaryhisterectomy by estimating the efficiency of the propofol target-dose, evaluating the cardiorespiratory and hemogasimetric attributes, and the bispectral scale index (BIS) as well as the recovery period characteristics. METHODS: Twenty anesthetized bitches were divided into two groups of 10 each (G1, G2). Animals of G1 were pre-treated with methotrimeprazine and anesthetized with target-controlled propofol infusion by means of a Harvard infusion pump combined to remifentanil through a syringe pump. RESULTS: Bradycardia and light hypotension, hemogasimetric and respiratory stability besides a good myorelaxation, more evident during continuous infusion and good hypnosis. CONCLUSIONS: Dosis used in both techniques, after methotrimeprazine pre-treatment and combined to the opioid, were efficient for the surgery. The target-controlled anesthesia required a smaller anesthetic consumption (propofol) with faster recovery periods.

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Section: Emg (%) Gi Giisupporting

confidence: 88%

Comparative study between target-controlled-infusion and continuous-infusion anesthesia in dogs treated with methotrimeprazine and treated with propofol and remifentanil

et al. 2008

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“…Doppler flow technology using high-resolution vessel images combined with haemodynamic monitoring can provide extensive data on cardiovascular effects of drugs 18 . Administration of propofol has limited effects on heart contractility 19 , although it induces arterial hypotension primarily by reducing vascular tone and venous return 20 as well as producing peripheral vasodilatation 17 . However, Nakamura et al 21 demonstrated that clinically relevant concentrations of propofol did not have direct vasodilator effects.…”

Section: Discussionmentioning

confidence: 99%

Kısa-Etkili Anesteziklerin Tavşanlarda Hemodinamik Fonksiyonlara Etkilerinin Doppler Ultrasonografi ile Değerlendirilmesi

Kaya¹,

Pekcan²,

Şen³

et al. 2009

Kafkas Univ Vet Fak Derg

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SummaryThis study was carried out to determine the effects of short-acting anaesthetics on haemodynamic function determined by Doppler ultrasonography. Prior to anaesthesia, Doppler parameters [peak systolic blood flow velocity (psBFV), end-diastolic blood flow velocity (edBFV), minimum diastolic blood flow velocity (mdBFV) and resistive index (RI)] were obtained from the right common carotid artery (CCA), abdominal aorta (AA) and right kidney in New Zealand rabbits (n=24). Animals were then divided into 3 groups to be anaesthetized with propofol (Group P), 2.5% thiopental sodium (Group T) and xylazine/ketamine HCl (Group XK). During anaesthesia the same Doppler measurements were made. Compared with baseline values, psBFV obtained from CCA increased in Group P (P<0.02) and insignificantly changed in Groups T and XK. psBFV measured from AA in Groups T and XK decreased as compared with baseline values. In the right kidney, psBFV in Group P and edBFV in Group T increased, whereas RI value in Groups T and XK decreased. In conclusion, comparing baseline values, propofol anaesthesia did not significantly alter RI measured from CCA and kidney and blood flow velocities measured from AA. The data suggest that propofol anaesthesia in rabbits results in minimal changes in Doppler parameters. Keywords: Short-acting anaesthetic, Haemodynamic function, Doppler ultrasonography, Rabbit Kısa-Etkili Anesteziklerin Tavşanlarda Hemodinamik Fonksiyonlara Etkilerinin Doppler Ultrasonografi ile Değerlendirilmesi ÖzetBu çalışma, kısa etkili anesteziklerin Doppler ultrasonografi ile saptanan hemodinamik fonksiyonlara etkilerini belirlemek amacıyla yürütüldü. Anestezi öncesi Yeni Zelanda tavşanlarının (n=24) sağ arteria carotis communis (CCA), aorta abdominalis (AA) ve sağ böbreğinden Doppler parametreleri [en yüksek sistolik kan akım hızı (psBFV), diyastol sonu kan akım hızı (edBFV), en düşük diyastolik kan akım hızı (mdBFV) ve rezistif indeks (RI)] elde edildi. Hayvanlar propofol (Grup P), %2.5 tiyopental sodyum (Grup T) ve ksilazin/ ketamin HCl (Grup XK) ile anestezi altına alınarak, üç grup oluşturuldu. Anestezi sırasında aynı ölçümler tekrarlandı. Bazal değerler ile karşılaştırıldığında CCA'dan elde edilen psBFV Grup P'de yükseldi ve Grup T ve XK'daki değişim önemsizdi. Grup T ve XK'da AA'dan ölçülen psBFV bazal değerler ile kıyaslandığında azaldı. Sağ böbrekte, Grup P'nin psBFV ve Grup T'nin edBFV değerleri artarken, Grup T ve XK'da RI değeri azaldı. Sonuç olarak, propofol anestezisi bazal parametreler ile karşılaştırıldığında, CCA'deki RI, intrarenal RI ve AA'daki kan akımı hızlarını önemli ölçüde değiştirmediği tespit edildi. Veriler propofol anestezisinin tavşanlarda Doppler parametrelerini minimal düzeyde etkilediğini göstermektedir.

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“…Propofol is known to induce greater reduction in systolic arterial pressure than sodium thiopental 6 , as well as to produce 12% and 15% decreases in cardiac output and systemic vascular resistance, respectively 7 . Such lowering in vascular resistance has been attributed to sympathetic activity inhibition, while cardiac output reduction may be associated with decreased intracellular calcium availability resulting from reduced trans-sarcolemmal calcium influx 8,9 .…”

Section: Hemodynamicsmentioning

confidence: 99%

Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits

et al. 2013

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PURPOSE:To compare the incidence of endothelial injury after single-dose or continuous propofol infusion in conventional lipidbased emulsion (LE) versus microemulsion (ME). METHODS:Forty-two rabbits (2.5-4.5 Kg) were randomly allocated into seven groups of six animals each: SHAM-surgical treatment alone; Bolus Control Group -3 mL-intravenous (IV) bolus of saline; Continuous Infusion Control Group -3 mL-IV bolus of saline followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Bolus LE Propofol Group -IV bolus of LE propofol (3 mg/kg); Bolus ME Propofol Group -IV ME propofol bolus (3 mg/kg); Continuous LE Propofol Group -IV LE propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min; Continuous ME Propofol Group -IV ME propofol bolus (3 mg/kg) followed by a continuous infusion of 0.2 ml/kg/min for 60 min. RESULTS:There were no statistically significant differences between the studied groups in blood pressure, in central venous pressure and in the biochemical profile. No significant differences were found in inflammatory mediators and in tissue analysis between the two emulsions.CONCLUSION: Microemulsion and lipid-based emulsion propofol had similar inflammatory, biochemical and microscopy profiles.Thus, microemulsion propofol can be used as an alternative to lipid-based emulsion propofol.

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Peripheral Vascular Effects of Thiopental and Propofol in Humans with Artificial Hearts

Cited by 121 publications

References 0 publications

Comparative study between target-controlled-infusion and continuous-infusion anesthesia in dogs treated with methotrimeprazine and treated with propofol and remifentanil

Comparative study between target-controlled-infusion and continuous-infusion anesthesia in dogs treated with methotrimeprazine and treated with propofol and remifentanil

Kısa-Etkili Anesteziklerin Tavşanlarda Hemodinamik Fonksiyonlara Etkilerinin Doppler Ultrasonografi ile Değerlendirilmesi

Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits

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