Peripherally, non-peripherally and axially pyrazoline-fused phthalocyanines: synthesis, aggregation behaviour, fluorescence, singlet oxygen generation, and photodegradation studies

Abstract

Pyrazoline-fused peripheral zinc phthalocyanine (HY-ZnPcP) showed the highest singlet oxygen generation in DMSO, and it is thought to be a photosensitizer candidate for photodynamic therapy.

A comprehensive review on singlet oxygen generation in nanomaterials and conjugated polymers for photodynamic therapy in the treatment of cancer

“…The authors suggested that, the HY-ZnPcp molecule, Φ Δ 0.73%, which produced the most singlet oxygen among the three produced phthalocyanines (HY-ZnPcp, HY-ZnPcnp, and HY-SiPc), could be regarded as a photosensitizer candidate for PDT. 149…”

Water-soluble phthalocyanine photosensitizers for photodynamic therapy

“…The highly effective reactivity of singlet oxygen can cause severe damage to biological systems such as DNA and RNA, resulting in cell death. When enough singlet oxygen is produced during the energy transfer from the photosensitizer to the oxygen molecule, effective cell death can be obtained [ 49 ].…”