Peritoneal bile acids concentration in adult horses with hepatic and gastrointestinal disorders

Abstract

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Clinical insights: Clinicopathological parameters for diagnosing and predicting outcome of horses with colic

“…17 Another study looks at the value of peritoneal fluid bile acids (PBAC) in horses admitted to a referral centre for either colic or suspected hepatic disease and a group of healthy horses. 18 Bile peritonitis is seen in humans and small animals mainly in cases of the primary gall bladder or bile duct disease or abdominal trauma affecting the biliary tract or gall bladder. Horses with hepatic disease or strangulating and inflammatory intestinal disease had significantly higher peritoneal bile acids (3.29 μmol/L [IQR: 1.36-5.5 μmol/L]) than healthy horses or horses with a simple intestinal obstruction (1.00 μmol/L [IQR: 0.59-1.49 μmol/L] and 1.20 μmol/L [IQR: 0.75-1.66 μmol/L], respectively).…”

“…Horses with hepatic disease or strangulating and inflammatory intestinal disease had significantly higher peritoneal bile acids (3.29 μmol/L [IQR: 1.36-5.5 μmol/L]) than healthy horses or horses with a simple intestinal obstruction (1.00 μmol/L [IQR: 0.59-1.49 μmol/L] and 1.20 μmol/L [IQR: 0.75-1.66 μmol/L], respectively). 18 The measurement of peritoneal bile acids could potentially be used to help differentiate strangulating and nonstrangulating colic lesions, although there was no difference in this marker between the hepatic disease and ischaemic or inflammatory intestinal disease groups therefore using PBAC would be unhelpful to decide the need for surgery (since it is unable to differentiate between cases of enteritis and strangulating lesions). Complete serum biochemical analysis was not performed on all colic cases, and therefore it is possible there was a component of primary hepatic dysfunction in the horses with high peritoneal fluid bile acids.…”

“…1.58-6.53 μmol/L] vs. 1.34 μmol/L [IQR: 0.82-3 μmol/L], respectively). 18 Based on the findings, measurement of either peritoneal CK activity or peritoneal bile acid activity appears to have limited utility for differentiating between strangulating and nonstrangulating obstructions particularly given the lack of availability of point-of-care tests.…”

“…Another study looks at the value of peritoneal fluid bile acids (PBAC) in horses admitted to a referral centre for either colic or suspected hepatic disease and a group of healthy horses 18 . Bile peritonitis is seen in humans and small animals mainly in cases of the primary gall bladder or bile duct disease or abdominal trauma affecting the biliary tract or gall bladder.…”

“…Bile peritonitis is seen in humans and small animals mainly in cases of the primary gall bladder or bile duct disease or abdominal trauma affecting the biliary tract or gall bladder. Horses with hepatic disease or strangulating and inflammatory intestinal disease had significantly higher peritoneal bile acids (3.29 μmol/L [IQR: 1.36–5.5 μmol/L]) than healthy horses or horses with a simple intestinal obstruction (1.00 μmol/L [IQR: 0.59–1.49 μmol/L] and 1.20 μmol/L [IQR: 0.75–1.66 μmol/L], respectively) 18 . The measurement of peritoneal bile acids could potentially be used to help differentiate strangulating and nonstrangulating colic lesions, although there was no difference in this marker between the hepatic disease and ischaemic or inflammatory intestinal disease groups therefore using PBAC would be unhelpful to decide the need for surgery (since it is unable to differentiate between cases of enteritis and strangulating lesions).…”