Peritoneal cancer index: a prognostic indicator of survival in advanced ovarian cancer

Tentes, Antonios-Apostolos; Tripsiannis, Gregory A.; Markakidis, S.; Karanikiotis, Charisios; Tzegas, Georgios I.; Georgiadis, George S.; Avgidou, K.

doi:10.1053/ejso.2002.1380

Cited by 122 publications

(53 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although factors such as CA125 levels and ascites may reflect the degree of carcinomatosis, these levels have not reached a sufficient degree of sensitivity, specificity, and the predictive values required to make decisions in this regard. As a result, resectability scores or even imaging tests such as high-resolution MRI have been attempted to be used, without achieving any optimal results in the detection of peritoneal carcinomatosis [16,34,35]. Interestingly, only 46% of ESGO members report using exploratory laparoscopy as a means to assess resectability.…”

Section: Discussionmentioning

confidence: 99%

Impact of Laparoscopy to Assess Resectability in Stage IIIC Epithelial Ovarian, Tubal and Peritoneal Cancer Patients

Sánchez-Iglesias

Pérez-Benavente

Correa-Paris

et al. 2018

Gynecol Obstet Invest

View full text Add to dashboard Cite

Aims: To evaluate overall survival (OS) and progression-free survival (PFS) in patients with stage IIIC epithelial ovarian, tubal and peritoneal cancer (EOC) who underwent a laparoscopy to assess surgical resectability prior to Primary Debulking Surgery (PDS) or Interval Debulking Surgery (IDS). Methods: Retrospective cohort study that included all women with stage IIIC EOC treated at our center between 2000 and 2010. Patients were classified in groups: PDS, neoadjuvant chemotherapy (NACT) with IDS, NACT without IDS; and then sub-classified based on residual tumor (RT). A laparoscopy to assess resectability was performed before PDS and IDS. Results: Among 111 patients included, 66 underwent PDS, and 45 were treated with NACT, 80% of them receiving subsequent IDS. OS was 75.6 months in the PDS group, and 52.8 months for IDS group (p = 0.100); the PFS was 30 months and 19.2 months respectively (p = 0.049). Median OS was 104.4 and 52.8 months for patients with optimal cytoreduction (RT = 0) in the PDS and IDS group respectively (p < 0.05). Laparoscopy did not modify the preoperative consideration for PDS; however, 9 laparotomies were avoided based on laparoscopic findings after NACT. Conclusion: Laparoscopy for the assessment of surgical resectability in stage IIIC EOC has no impact on survival; but it still could be useful for the reduction of unnecessary laparotomies after NACT.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of Laparoscopy to Assess Resectability in Stage IIIC Epithelial Ovarian, Tubal and Peritoneal Cancer Patients

Sánchez-Iglesias

Pérez-Benavente

Correa-Paris

et al. 2018

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…Dutch Simplified Peritoneal Cancer Index [4] . TNM system [25] Journal of Surgical Oncology [2] Prognostic value proven in other clinical trials (gastric cancer) [13][14][15] Simple [19] Can also be applied to patients Inability to accurately locate the carcinomatosis with recurrent gastric cancer [19] It has no size assessment of the cancerous implants [19] Peritoneal Cancer Index [3] Prognostic value proven in colon cancer [15][16][17] and ovarian cancer [18] Reproducible [19] PCI has no prognostic implication in the following possible cases: Allows to estimate the probability of a complete cytoreduction [20] Is a guide for sequential determinations of volume of carcinomatosis Non-invasive disease such as Pseudomyxoma peritonei [22] in which a high PCI not necessary is correlated with a poor prognosis over time estimating the likelihood of a complete cytoreduction at re-operative surgery [8] Allows a correlation with the incidence of complications in patients who A patient with invasive cancer at a crucial anatomic site (around the common bile duct), even if the tumor elsewhere is of low burden, the prognosis will be poor [19] …”

Section: Methodsmentioning

confidence: 99%

The intraoperative staging systems in the management of peritoneal surface malignancy

Portilla¹,

Kusamura

Baratti

et al. 2008

Journal of Surgical Oncology

111

View full text Add to dashboard Cite

The establishment of a rationale guideline for intraoperative staging system the extent of carcinomatosis is warranted. The quantitation of tumor found at the time of surgical exploration of the abdomen has proven to be of value in assessment of prognosis and treatment planning in patients with peritoneal carcinomatosis. Four different assessments systems have been employed more frequently, thus far. The advantages and disadvantages of each classification systems are described and discussed. The results of the Consensus of the last 5th International Workshop on Peritoneal Surface malignancy of Milan, December 2006 are presented.

show abstract

“…A few years after PCI introduction, Tentes et al [52] evaluated the score for OC. OC with intraperitoneal dissemination can be effectively treated with CRS, 64 S. Giacopuzzi et al …”

Section: Ovarian Cancermentioning

confidence: 99%

Classification of Intraperitoneal Spread

Giacopuzzi

Guerini²,

Zanoni³

et al. 2015

Treatment of Peritoneal Surface Malignancies

View full text Add to dashboard Cite

Peritoneal cancer index: a prognostic indicator of survival in advanced ovarian cancer

Cited by 122 publications

References 14 publications

Impact of Laparoscopy to Assess Resectability in Stage IIIC Epithelial Ovarian, Tubal and Peritoneal Cancer Patients

Impact of Laparoscopy to Assess Resectability in Stage IIIC Epithelial Ovarian, Tubal and Peritoneal Cancer Patients

The intraoperative staging systems in the management of peritoneal surface malignancy

Classification of Intraperitoneal Spread

Contact Info

Product

Resources

About