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Apoptosis-related proteins play an important role in lymphoma cell death during chemotherapy. In our study, we investigated the prognostic significance of CD95, BCL2, and P53 expression in extranodal non-Hodgkin's lymphoma (NHL). We examined 71 patients with extranodal NHL [45 diffuse large B-cell lymphomas (DLBCLs) and 26 mucosa-associated lymphoid tissue lymphomas (MALTLs)], 35 male and 36 female, with a median age of 65.8 years. The most common site of origin was the stomach (N = 31). Paraffin-embedded specimens were analyzed immunohistochemically for CD95, BCL2, and P53 expression. Multivariate analysis revealed that in DLBCLs, positive CD95 and negative BCL2 expression were independent prognostic factors for overall survival. We reached the same conclusion for MALTLs, with positive CD95 and negative P53 expression. In DLBCLs, the 5-year overall survival rate was 71.5% for the CD95-positive cases and 35% for the CD95-negative cases (p = 0.004) and the 5-year overall survival was significantly better in BCL2-negative cases (70.8%) when compared to BCL2-positive cases (37%; p = 0.009). In MALTLs, the 5-year overall survival rate for the CD95-positive and CD95-negative groups was 89.5% and 42.9%, respectively (p = 0.004) and the 5-year overall survival rate was 50% for the P53-positive cases and 88.9% for the P53-negative cases (p = 0.016). In conclusion, positive CD95 expression proved to be a good prognostic factor of overall survival in both extranodal DLBCLs and MALTLs. In contrast, positive expression of BCL2 and P53 was found to be unfavorably associated with survival in extranodal DLBCLs and MALTLs, respectively.

It is concluded that for mini abdominoplasty, adequate analgesia is achieved for at least 4 h postoperatively by local tissue infiltration with either ropivacaine or levobupivacaine. However, in terms of intensity and duration of analgesia, levobupivacaine was found to be more effective than ropivacaine in reducing postoperative pain associated with mini abdominoplasty.

Breastfeeding following reduction mammaplasty by using 3 different techniques is evaluated in this retrospective study. A questionnaire was sent to 178 patients who had undergone the operation at childbearing age and provided data on quality and duration of preoperative and postoperative breastfeeding, as well as reasons for not attempting or failing. Demographic data and operative details were obtained from patients' records. One hundred six of the patients who replied to the questionnaire and had given birth after reduction mammaplasty were included in this study. Breastfeeding was considered successful if it was performed for at least 3 weeks without supplementation. For women who attempted to breastfeed postoperatively, successful rates were 71% for superior pedicle mammaplasty, 77% for the inferior pedicle technique, and 63% following horizontal bipedicled reduction mammaplasty. However, 22% of women had not made any attempt to breastfeed at all after breast reduction. The postoperative ability to breastfeed was not found to relate to the amount of resected breast tissue or the time elapsing between operation and delivery. It is concluded that after breast reduction with pedicled transposition of the nipple-areola complex and preservation of adequate subareolar breast tissue, the ability to breastfeed highly depends on encouragement and support offered to women rather than the choice of the operative technique.