Peritoneal Carcinomatosis Arising from Primary Anorectal Melanoma

McBride, Michelle; Calhoun, Sean

doi:10.3941/jrcr.v13i4.3458

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…Similar to mice injected with UV‐irradiated cells, extensive metastasis was observed throughout the peritoneal cavity in 13 of 14 mice (Table EV1; Fig 2L). Although less common for melanoma, there is evidence showing that several metastatic cancers have been known to penetrate the peritoneal cavity through the peritoneal wall, a process commonly referred to as intraperitoneal carcinomatosis (IC) (Lee et al , 2014; Mikuła‐Pietrasik et al , 2018; McBride & Calhoun, 2019; Desai & Moustarah, 2020). Additionally, when O1DN cells were injected s.c., three of 10 mice exhibited contact with the peritoneal wall (Table EV1; Fig 2L,M).…”

Section: Resultsmentioning

confidence: 99%

Suppression of Ca²⁺ signaling enhances melanoma progression

et al. 2022

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Ca 2+ is a ubiquitous and dynamic second messenger molecule that is induced by many factors including receptor activation, environmental factors, and voltage, leading to pleiotropic effects on cell function including changes in migration, metabolism and transcription. As such, it is not surprising that aberrant regulation of Ca 2+ signals can lead to pathological phenotypes, including cancer progression. However, given the highly context-specific nature of Ca 2+ -dependent changes in cell function, delineation of its role in cancer has been a challenge. Hence, the role of store-operated Ca 2+ entry (SOCE) in melanoma metastasis is still not fully elucidated. To address this, we examined UVdependent metastasis, revealing a critical role for SOCE suppression. As previous literature demonstrated a role for cholesterol (CHL) in melanoma progression, our investigations corroborate this revealing UV-induced CHL biosynthesis as a critical mediator for UV-induced SOCE suppression and subsequent metastasis. However, SOCE suppression alone was both necessary and sufficient for metastasis to occur. CHAPTER 1 INTRODUCTION Part 1: Calcium I. Ca 2+ signal generation: Ca 2+ signals are generated in response to a wide variety of autocrine, paracrine, hormonal, neurocrine and environmental factors. Here, we will briefly discuss some of the major underlying approaches that cells use to generate Ca 2+ responses. A. Receptor-mediated control of Ca 2+ signals G-Protein Coupled Receptor (GPCR) and Receptor Tyrosine Kinase (RTK) families are widely expressed and facilitate Ca 2+ responses in virtually all cell types through phospholipase C (PLC). Briefly, as shown in Figure 1-1, when Gαq-coupled GPCRs (driving PLCβ activation) or RTKs with PLCγ docking sites are activated, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into Inositol Trisphosphate (InsP3) and diacylglycerol (DAG). InsP3 diffuses within the cell towards the ER where it encounters InsP3 Receptors (InsP3Rs), ER-localized Ca 2+ channels that mediate ER Ca 2+ release. The resultant ER Ca 2+ depletion leads to a highly conserved process known as store-operated Ca 2+ entry (SOCE) (4-7). SOCE is initiated by Stromal Interaction Molecule (STIM), a single pass membrane protein that acts as an Endoplasmic Reticulum (ER) Ca 2+ sensor, responding to ER Ca 2+ depletion by translocating within the ER towards the plasma membrane (PM) where it binds to and activates members of the Orai family of Ca 2+ -selective channels (6, 8). STIM1 and Orai1 serve as the predominant mediators of SOCE in most cell types (8), although the other members of the STIM and Orai families can function analogously, although with distinct characteristics. For example, a decrease

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Section: Resultsmentioning

confidence: 99%

Suppression of Ca²⁺ signaling enhances melanoma progression

et al. 2022

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“…Hillenbrand et al [28] showed that tumour thickness <4 mm appears to be correlated with longer disease‐free survival. Unfortunately, the poor prognosis of ARMM is contributed to by the fact that patients are usually admitted with advanced stages of cancer [13,29]. Most of our patients (35.3%) presented with Stage III disease.…”

Section: Discussionmentioning

confidence: 99%

Primary melanoma of the anorectal region: clinical and histopathological review of 17 cases. A retrospective cohort study

2021

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Aim The aim of our study was to scrutinize diagnostic and treatment factors that may contribute to the low survival rate from anorectal melanoma while adding 17 more cases to the global research database. Method We carried out a retrospective analysis of 17 cases of anorectal melanoma treated at a single institution from 2000 to 2020. Data on patient age, sex, complaints, treatment and survival as well as tumour size, resection margins, histological and immunohistochemical features were assessed. Results The median age of patients was 72 ± 12.49 (45–92) years. Most of the patients were women (n = 11, 64.71%). Three (17.65%) patients underwent no radical treatment. Of eight patients treated initially with radical surgery (either total mesorectal excision or abdominoperineal resection), six (75%) were found to have positive lymph nodes. Mean survival was 20 ± 23.46 (1–84) months. The average diameter of the resected tumours was 5.43 ± 3.02 cm (1.3–10 cm). Most tumours had epithelioid or spindle cell morphology and were positive for one or more melanocytic markers (S100, HMB‐45 or MITF). More than half of the tumours contained no or very little melanin pigment. None of the tumours had significant lymphocytic infiltration. Three tumours showed positivity for keratins (PANCK or CAM5.2) and one tumour showed positivity for C‐KIT stain. Conclusion An aggressive surgical approach may have an effect on survival in most early stages while more advanced disease benefits from a more conservative approach. Attention to sentinel lymph nodes and further systemic research into therapy is required. For now, treatment and diagnostic modalities seem to be inconsistent, requiring further investigation to elucidate common points.

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“…Esse envolvimento comumente é um achado incidental detectado durante exploração cirúrgica ou em exames de imagem como TC ou ressonância magnética (RM). A biópsia das lesões suspeitas é capaz de confirmar o diagnóstico e diferenciar de possíveis condições e tumores primários do peritônio, como linfomatose, tuberculose, pseudomixoma peritoneal, sarcomatose e mesotelioma 2,5 .…”

Section: Discussionunclassified

Sítio Metastático Incomum - Metástases Peritoneais em Melanoma Maligno: Relato de Caso

Anjos¹,

Mari²,

Vidotti³

et al. 2021

Rev. Bras. Cancerol.

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Introdução: O melanoma cutâneo é um tumor com grande capacidade de metastização. Um dos quadros possíveis, mas bastante raro, é quando a metástase se aloja em peritônio (carcinomatose peritoneal). Relato do caso: Paciente feminina, 61 anos, encaminhada por massa inguinal esquerda suspeita e lesão hipercrômica de 2 cm, com área de regressão em membro inferior esquerdo. A paciente foi submetida à linfadenectomia inguinal esquerda e ressecção da lesão de pele, que evidenciou melanoma maligno cutâneo extensivo superficial invasor, de espessura de Breslow 1,2 mm, e nível de Clark II, bem como metástase linfonodal. O tratamento adjuvante incluiu radioterapia e quimioterapia. Durante follow-up, oito meses depois, ultrassonografia e tomografia computadorizada de abdome evidenciaram imagem nodular sólida hipoecoica, heterogênea e bosselada, mal definida e mal delimitada em projeção para-aórtica à esquerda, com 12,7x6,7x4,8 cm. Em laparotomia exploradora, encontrou-se massa volumosa retroperitoneal em flanco esquerdo, com envolvimento do ângulo de Treitz e presença de carcinomatose peritoneal. O laudo anatomopatológico evidenciou neoplasia maligna pouco diferenciada epitelioide infiltrativa, compatível com história clínica de melanoma. A paciente evoluiu a óbito após consulta com oncologia clínica. Conclusão: Existem poucos casos de metástase peritoneal de melanoma relatados na literatura. Contudo, deve-se levar em consideração sua possibilidade de ocorrência e as opções terapêuticas disponíveis, além de também compreender seu impacto no prognóstico do paciente. Apesar de rara, a carcinomatose peritoneal deve ser considerada quando pacientes com histórico pessoal de melanoma apresentarem queixas abdominais inespecíficas, como a paciente do caso relatado.

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Peritoneal Carcinomatosis Arising from Primary Anorectal Melanoma

Cited by 6 publications

References 18 publications

Suppression of Ca²⁺ signaling enhances melanoma progression

Suppression of Ca²⁺ signaling enhances melanoma progression

Primary melanoma of the anorectal region: clinical and histopathological review of 17 cases. A retrospective cohort study

Sítio Metastático Incomum - Metástases Peritoneais em Melanoma Maligno: Relato de Caso

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Peritoneal Carcinomatosis Arising from Primary Anorectal Melanoma

Cited by 6 publications

References 18 publications

Suppression of Ca2+ signaling enhances melanoma progression

Suppression of Ca2+ signaling enhances melanoma progression

Primary melanoma of the anorectal region: clinical and histopathological review of 17 cases. A retrospective cohort study

Sítio Metastático Incomum - Metástases Peritoneais em Melanoma Maligno: Relato de Caso

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Suppression of Ca²⁺ signaling enhances melanoma progression

Suppression of Ca²⁺ signaling enhances melanoma progression