Peritoneal Dialysis Modality Failure in a Middle-Income Country: A Retrospective Cohort Study

Vesga, Jasmín; Rodríguez, Néstor; Sanabria, Rafael M

doi:10.1016/j.xkme.2020.12.010

Cited by 9 publications

(15 citation statements)

References 30 publications

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“…Other studies have found other factors linked with an increased risk of PD discontinuation, such as peritonitis and male sex [24]. In addition, the outcome disparity between the two sexes has been observed in some studies but has not been explained.…”

Section: Discussionmentioning

confidence: 94%

Growing a Peritoneal Dialysis Program in Palestine from Zero to 178 Patients in 5 Years: A Single-Center Experience

Taher

Enaya

Sarsour

et al. 2022

Preprint

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Introduction: Kidney failure is rapidly rising in Palestine, as the number of patients receiving maintenance dialysis has quadrupled in the last 15 years. In this study, we share an overview of our experience growing a peritoneal dialysis (PD) program from zero to 178 patients in five years at An-Najah National University Hospital in Palestine, presenting some challenges and ways to overcome them. Methods: This was a single-center retrospective study of patients treated with PD from November 2016 to December 2021. Demographic and clinical data were obtained for each patient. In addition, PD discontinuation and peritonitis rates were calculated and presented as the primary patient outcomes. Results: A total of 158 patients were eligible for the study. The mean age was 51.8 ± 16.4 years, and 53.8% of patients were male. Diabetic nephropathy was the most common cause of kidney failure. Sixty-three episodes of peritonitis were diagnosed in 48 patients (30.4%) for a rate of 1 episode/ 38.2 patient-months (0.31 episodes/ patient-years). Twenty patients had their PD treatment discontinued, mainly due to psychosocial reasons and infectious and mechanical complications. Death was the fate of 27 patients, with cardiovascular disease and COVID-19 being the two main causes. Conclusion: The outcomes of this experience proved favorable and showed that PD could serve as a viable option for kidney failure patients in Palestine. Moreover, this study can serve as an example for other places where circumstances are challenging to take the initiative of starting their PD programs.

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Section: Discussionmentioning

confidence: 94%

Growing a Peritoneal Dialysis Program in Palestine from Zero to 178 Patients in 5 Years: A Single-Center Experience

Taher

Enaya

Sarsour

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Other studies have found other factors linked with an increased risk of PD discontinuation, such as old age, diabetes, peritonitis, and male sex [ 25 , 26 ]. The outcome disparity between the two sexes has been observed in some studies but has not been explained.…”

Section: Discussionmentioning

confidence: 99%

Growing a peritoneal dialysis program in Palestine from zero to 178 patients in 5 years: a single-center experience

et al. 2023

View full text Add to dashboard Cite

Introduction Kidney failure is rapidly rising in Palestine, as the number of patients receiving maintenance dialysis has quadrupled in the last 15 years. In this study, we share an overview of our experience growing a peritoneal dialysis (PD) program from zero to 178 patients in 5 years at An-Najah National University Hospital in Palestine, presenting some challenges and ways to overcome them. Methods This was a single-center retrospective study of patients treated with PD from November 2016 to December 2021. Demographic and clinical data were obtained for each patient. In addition, PD discontinuation, peritonitis, and mortality rates were calculated and presented as the primary patient outcomes. Results A total of 158 patients were eligible for the study. The mean age was 51.8 ± 16.4 years, and 53.8% of patients were male. Diabetic nephropathy was the most common cause of kidney failure. 63 episodes of peritonitis were diagnosed in 48 patients (30.4%) for a rate of 1 episode/ 38.2 patient-months (0.31 episodes/ patient-years). 20 patients had their PD treatment discontinued, mainly due to psychosocial reasons and infectious and mechanical complications. Death was the fate of 27 patients, with cardiovascular disease and COVID-19 being the two main causes. Conclusion The outcomes of this experience proved favorable and showed that PD could serve as a viable option for kidney failure patients in Palestine. Moreover, this study can serve as an example for other places where circumstances are challenging to take the initiative of starting their PD programs.

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“…Studies have shown that peritonitis is one of the most important causes for technique failure with PD [ 41 , 42 ]. Despite the heightened risk of peritonitis, death-censored technique survival was not found to be significantly different between elderly and non-elderly patients in our meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of peritoneal dialysis in elderly vs non-elderly patients: A systemic review and meta-analysis

Jiang

Zheng

2022

PLoS ONE

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Objectives Several studies have compared outcomes of peritoneal dialysis (PD) between elderly and non-elderly patients but with variable results. We hereby designed this review to compare mortality, peritonitis, and technique survival between elderly and non-elderly patients on PD. Methods PubMed, Embase, and Google Scholar were searched for studies comparing outcomes of PD between elderly and non-elderly patients. The last search date was 14th July 2021. Results Fourteen studies were included. 12 studies defined the elderly as ≥65 years of age and these were included in the meta-analysis. Pooled analysis of crude (RR: 2.45 95% CI: 1.36, 4.40 I2 = 97% p = 0.003) and adjusted data (HR: 2.80 95% CI: 2.45, 3.09 I2 = 0% p<0.00001) indicated a statistically significant increased risk of mortality amongst elderly patients as compared to non-elderly patients. Meta-analysis of four studies demonstrated a statistically significant increased risk of peritonitis in the elderly (RR: 1.56 95% CI: 1.18, 2.07 I2 = 76% p = 0.002). Pooled analysis demonstrated no statistically significant difference in technique survival between the two groups (RR: 0.95 95% CI: 0.86, 1.05 I2 = 86% p = 0.32). Conclusion Elderly patients on PD have a significantly increased risk of mortality as compared to non-elderly patients. The risk of peritonitis is also significantly increased in older adults but the increased age has no impact on technique survival. Further studies are needed to strengthen our conclusions.

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Peritoneal Dialysis Modality Failure in a Middle-Income Country: A Retrospective Cohort Study

Cited by 9 publications

References 30 publications

Growing a Peritoneal Dialysis Program in Palestine from Zero to 178 Patients in 5 Years: A Single-Center Experience

Growing a Peritoneal Dialysis Program in Palestine from Zero to 178 Patients in 5 Years: A Single-Center Experience

Growing a peritoneal dialysis program in Palestine from zero to 178 patients in 5 years: a single-center experience

Outcomes of peritoneal dialysis in elderly vs non-elderly patients: A systemic review and meta-analysis

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