Peritoneal fluid from endometriosis patients affects reproductive outcome in an in vivo model

Steinleitner, Alex; Lambert, Hovey; Kazensky, Carol; Danks, Patricia

doi:10.1016/s0015-0282(16)53533-x

Cited by 28 publications

(10 citation statements)

References 15 publications

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“…Although earlier studies showed the effect of the PF of endometriosis on the reproductive outcome in an in vivo model (33), there are no reports evaluating the effect of endometriosis on the microtubules and chromosomal alignment in MII oocytes. Therefore, we evaluated the effects of the PF obtained from women with endometriosis with all its constituents on the oocyte spindle and chromosomal alignment using mature MII mouse oocytes as our model.…”

Section: Discussionmentioning

confidence: 97%

Endometriosis-induced alterations in mouse metaphase II oocyte microtubules and chromosomal alignment: a possible cause of infertility

Mansour

Sharma

Agarwal

et al. 2010

Fertility and Sterility

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Section: Discussionmentioning

confidence: 97%

Endometriosis-induced alterations in mouse metaphase II oocyte microtubules and chromosomal alignment: a possible cause of infertility

Mansour

Sharma

Agarwal

et al. 2010

Fertility and Sterility

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“…Controversy surrounding the relationship between infertility and minimal or mild forms of endometriosis has arisen primarily because of the lack of data demonstrating efficacy of treatment protocols on cycle fecundity in women with this disorder 101,102. While animal models103‐106 and some clinical studies107 have supported an adverse effect of endometriosis on pregnancy rates, others fail to reveal this association 108,109. Results from in vitro fertilization with embryo transfer (IVF‐ET) have also been divergent in their conclusions 110,111.…”

Section: Endometrium From Women With Infertility and Endometriosismentioning

confidence: 99%

Implantation Defects in Infertile Women with Endometriosis

Lessey¹

2002

Annals of the New York Academy of Sciences

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The endometrium undergoes characteristic histologic changes during the menstrual cycle as it prepares for embryo implantation. Historic and current data suggest the presence of a defined period of maximal uterine receptivity during the mid-secretory phase occurring between days 7 and 10 postovulation. In recent years, we and others have sought to define biochemical markers of receptivity that might be used to better understand this time of endometrial differentiation. Based on the work with cell adhesion molecules, we have discovered three different integrins that are only coexpressed during this time in the cycle when embryos will successfully implant. By studying the regulation of one of these, the alpha(v)beta3 integrin, and its extracellular matrix ligand, osteopontin (OPN), we have defined two separate regulatory pathways that may regulate endometrial receptivity. While alpha(v)beta3 expression appears to be stimulated by EGF or heparin-binding EGF, osteopontin is stimulated by progesterone. We now believe the former pathway is a paracrine-mediated signal, while the latter is a direct effect of progesterone on the estrogen-primed endometrial epithelium. In women with endometriosis, it appears that alpha(v)beta3 expression is reduced, while OPN expression is unaffected. Interestingly, binding of OPN to the surface epithelium appears quite limited when alpha(v)beta3 expression is lacking. Such evidence continues to reinforce the notion that endometrium from some women with endometriosis is dysfunctional and may account for the reduction in cycle fecundity noted in this group of patients.

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“…Evidence shows that the peritoneal fluid of women with endometriosis reduces implantation rates in the mouse [67] and the hamster [68]. Oxidative stress was shown to induce genomic and mitochondrial DNA damage, which leads directly to a decrease in fertility.…”

Section: Discussionmentioning

confidence: 99%