Peritoneal Serous Papillary Adenocarcinoma: Report of Four Cases

Minami, Takeshi; Nakatani, Koji; Kondo, Shinya; Kanayama, Shuji; Tsujimura, Takahiro

doi:10.2169/internalmedicine.44.944

Cited by 10 publications

(1 citation statement)

References 22 publications

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“…This disease is clinically difficult to differentiate from papillary mesothelioma and metastatic tumours of the peritoneum 5. The most common symptoms include abdominal distension and bloating; macroscopically these tumours present with multiple small nodules on the surface of the peritoneum.…”

Section: Discussionmentioning

confidence: 99%

Mesothelial reaction in longstanding Crohn’s ileitis simulating papillary mesothelioma

Wilkinson

Bloxham

2008

J Clin Pathol

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Intestinal and extraintestinal complications of Crohn's disease are well documented. Changes in the connective tissue within the intestinal wall and surrounding tissue including mesenteric fat are characteristically seen in resected and autopsy specimens. A rare and unusually florid mesothelial reaction in the surrounding small bowel serosa of a patient with a 2-year history of Crohn's ileitis is described. The peritoneal surface of the ileal resection specimen displayed exuberant tubulo-papillary formations of the mesothelium, with superficial invasion of the underlying stroma. The case demonstrates the well-recognised difficult differential diagnosis between a benign mesothelial proliferation and malignant mesothelioma in a novel clinical setting, and the diversity of the extramural manifestations of Crohn's disease.

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Section: Discussionmentioning

confidence: 99%

Mesothelial reaction in longstanding Crohn’s ileitis simulating papillary mesothelioma

Wilkinson

Bloxham

2008

J Clin Pathol

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Technical pitfalls potentially affecting diagnoses in immunohistochemistry

2008

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Result of the immunohistochemical reactions routinely used in diagnostic surgical pathology should be properly interpreted, since false results, related to technical and interpretative pitfalls may lead to incorrect diagnosis. The main sources of such pitfalls are reviewed, analytically described and related to different steps (fixation, tissue processing and embedding, decalcification, antigen retrieval) which may affect the accuracy of immunohistochemistry. In addition, the presence of endogenous enzyme activity, improper binding of avidin to endogenous biotin, incorrect use of antibodies, chromogen and detection systems, as well as incorrect interpretation may produce unreliable data. The high frequency and extension of such pitfalls make mandatory the use of internal and external controls and adoption of cross-validation programmes. The present study, supported by an extensive review of the related literature, is intended as a guideline leading to proper interpretation of immunohistochemical data, an essential component of the diagnostic process. Experience on the antigen retrieval procedures for different antigens is also presented.

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