Peritoneal tuberculosis due to Mycobacterium caprae

Nebreda, Teresa; Álvarez-Prida, E.; Blanco, Berenice; Remacha, María Antonia; Samper, Sofía; Jiménez, María Soledad

doi:10.1016/j.idcr.2016.02.010

Cited by 5 publications

(8 citation statements)

References 16 publications

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“…As the primary animal reservoir for M. caprae , it could be assumed that Peru’s large inventory of small ruminants would result in a large proportion of reported TB cases being attributed to M. caprae . However M. caprae accounts for a mere 0.3% of human TB cases with the great majority of these cases being reported in Europe [ 14 ]. In fact, to the best of our knowledge there are only two documented cases of M. Caprae infection in humans outside of Europe; both described in Morocco [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is unlikely that the apparent scarcity of M. caprae outside of Europe reflects the true epidemiology of zoonotic M. caprae in Peru but rather the lack of differentiation between M. caprae and the other members of the MTBC as the offending pathogen in reported TB cases [ 11 , 13 ]. M. caprae and M. tuberculosis have a very similar disease evolution and they are both typically drug-susceptible [ 14 ]. It is interesting to note that while M. caprae and M. bovis are often associated with extra-pulmonary presentations of TB, both of our patients presented with a symptoms profile consistent with classical pulmonary TB [ 13 , 14 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Finally M. caprae is not globally distributed and rarely occurs due to strain importation. The species is thought to be confined to Europe [ 13 , 14 ].

Fig.…”

Section: Introductionmentioning

confidence: 99%

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A case report of transmission and disease caused by Mycobacterium caprae and Mycobacterium bovis in Lima, Peru

Shrestha

Picoy²,

Torres

et al. 2021

BMC Infect Dis

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Background The Tuberculosis (TB) burden in Peru is significant with respect to both disease morbidity and mortality. Furthermore the recent diversification of farming enterprise to include a wide range of animal species has necessitated the consideration of members of the Mycobacterium Tuberculosis Complex (MTBC) with the potential for zoonotic transmission. M. bovis and M. caprae, a lesser known member of the MTBC exhibit an exceptionally wide host spectrum in animals and are capable of causing disease in humans. M. bovis has a predictable resistance profile which includes resistance to pyrazinamide. Thus, failure to identify M. bovis as the causative agent in reported TB cases leads to higher levels of treatment failure and contributes to the transmission of drug-resistant TB. Case presentation Reported here are the clinical presentations, investigations and treatment histories of two patients identified from a population level genotyping study in Lima, Peru that were at the time of treatment thought to be M. tuberculosis patients but in retrospect were spectated using whole genome sequencing as M. caprae and M. Bovis. Conclusions The cases reported here constitute convincing evidence that M. caprae and M. bovis are causative agents of TB infection in humans in Peru and underscore the importance of species-level MTBC member identification to effectively control and treat zoonotic TB. Furthermore these cases highlight the challenges of using clinical risk factors to identify cases of zoonotic TB in humans as their clinical presentation and transmission history is often difficult to distinguish from anthroponotic TB.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A case report of transmission and disease caused by Mycobacterium caprae and Mycobacterium bovis in Lima, Peru

Shrestha

Picoy²,

Torres

et al. 2021

BMC Infect Dis

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“…Gruźlica bydła (bovine tuberculosis, bTB, BTB) jest powolnie postępującą chorobą zakaźną spowodowaną przez kwasooporne prątki bydlęce: Mycobacterium bovis oraz Mycobacterium caprae, które należą do kompleksu Mycobacterium tuberculosis (MTBC) (27). Prątki bydlęce mogą być również czynnikiem etiologicznym gruźlicy u innych gatunków zwierząt gospodarskich, zwierząt wolno żyjących i ludzi (13,20,22,24). Gruźlica bydła generuje znaczne obciążenia ekonomiczne i zdrowotne, co uzasadnia rygorystyczne badania epidemiologiczne dotyczące monitorowania i kontroli tej zoonozy.…”

Section: Praca Oryginalna Original Paperunclassified

Molecular characterization of Mycobacterium tuberculosis complex strains isolated from cattle in Masovian Voivodeship in 2008-2012

Krajewska‐Wędzina¹,

Kozińska²,

Augustynowicz–Kopeć³

et al. 2018

Medycyna Weterynaryjna

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Since 2009, Poland has had a TB-free status, although over the last seven years 12-34 cases of bovine TB have been recorded annually. In 2009-2012 the largest number of cattle infected with Mycobacterium bovis and Mycobacterium caprae were culled in Masovian Voivodeship. Likewise, the largest number of sources of this zoonosis were recorded in that voivodeship. The vicinity of farms where bTB was found indicated that it could have been transmitted between their herds. The aim of this study was to characterise the molecular patterns of bovine bacillus strains isolated from cattle in Masovian Voivodeship and the molecular relationships between them. The material for microbiological examination came from 38 cattle (Bos taurus) located in 7 counties of Masovian Voivodeship. These 38 strains of MTBC were further identified as M. bovis (24 isolates; 63%) and M. caprae (14 isolates; 37%). A two-step genotyping analysis of the 38 MTBC strains identified 24 molecular patterns, closely related phylogenetically, which were assigned to 8 clusters of 2-6 strains. Sources of transmission were identified in 8 out of 13 herds examined in the 7 counties of Masovian Voivodeship. The results of the genotyping analysis excluded the possibility of TB transmission between different herds in Masovian Voivodeship. It was proved, however, that TB had been transmitted between animals bred on one of the farms..

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“…Dicho complejo está compuesto por varias especies diferentes de micobacterias. Epidemiológicamente, las más relevantes son: M. tuberculosis; Mycobacterium bovis (M. bovis), causante de la TB bovina; Mycobacterium africanum, que se subdivide en dos tipos (I y II), de los cuales, el tipo I se considera epidémico del Este de África 16 ; y Mycobacterium caprae, que es responsable de enfermedades en el ganado y, ocasionalmente, de patología en humanos 17 .…”

Section: Microbiologíaunclassified

Caracterización de parámetros inmunológicos en sangre de diabéticos infectada "in vitro" con "Mycobacterium tuberculosis" = Characterization of immunological response in blood from diabetic patients infected in vitro with "Mycobacterium tuberculosis"

García¹

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Peritoneal tuberculosis due to Mycobacterium caprae

Cited by 5 publications

References 16 publications

A case report of transmission and disease caused by Mycobacterium caprae and Mycobacterium bovis in Lima, Peru

A case report of transmission and disease caused by Mycobacterium caprae and Mycobacterium bovis in Lima, Peru

Molecular characterization of Mycobacterium tuberculosis complex strains isolated from cattle in Masovian Voivodeship in 2008-2012

Caracterización de parámetros inmunológicos en sangre de diabéticos infectada "in vitro" con "Mycobacterium tuberculosis" = Characterization of immunological response in blood from diabetic patients infected in vitro with "Mycobacterium tuberculosis"

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